Compounds > dehydroglyasperin c
Page last updated: 2024-12-08

dehydroglyasperin c

Description

dehydroglyasperin C: isolated from licorice, caused Nrf2-mediated induction of detoxifying enzymes; structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID480775
SCHEMBL ID5614039
MeSH IDM0545583

Synonyms (16)

Synonym
4-[7-hydroxy-5-methoxy-6-(3-methyl-but-2-enyl)-2h-1-benzopyran-3-yl]-benzene-1,3-diol
dehydroglyasperin c
4-[7-hydroxy-5-methoxy-6-(3-methylbut-2-enyl)-2h-chromen-3-yl]benzene-1,3-diol
SCHEMBL5614039
unii-80h8msz44i
1,3-benzenediol, 4-(7-hydroxy-5-methoxy-6-(3-methyl-2-butenyl)-2h-1-benzopyran-3-yl)-
80H8MSZ44I ,
1,3-benzenediol, 4-(7-hydroxy-5-methoxy-6-(3-methyl-2-buten-1-yl)-2h-1-benzopyran-3-yl)-
199331-35-6
AKOS032949120
dehydroglyasperinc
Q27269145
MS-25524
E80707
CS-0113425
HY-N7335

Research Excerpts

Overview

Dehydroglyasperin C (DGC) is a major isoflavone found in the root of licorice.

ExcerptReferenceRelevance
"Dehydroglyasperin C (DGC) is a major isoflavone found in the root of licorice."( Dehydroglyasperin C suppresses TPA-induced cell transformation through direct inhibition of MKK4 and PI3K.
Heo, YS; Jang, YJ; Jung, SK; Kim, JE; Kim, JR; Lee, CC; Lee, CY; Lee, E; Lee, HJ; Lee, JH; Lee, KW; Lim, SS; Lim, TG; Seo, SG; Son, JE, 2016)		2.6

Treatment

ExcerptReferenceRelevance
"Dehydroglyasperin C treatment also decreased the UVB irradiation-mediated activation of mitogen-activated protein kinase (MAPK), c-Jun phosphorylation, and c-Fos expression."( The effect of dehydroglyasperin C on UVB-mediated MMPs expression in human HaCaT cells.
Ha, JH; Jeong, YJ; Park, SN; Park, YM; Xuan, SH, 2017)		1.54
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (9)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's9 (100.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 17.88

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index17.88 (24.57)
Research Supply Index2.30 (2.92)
Research Growth Index5.00 (4.65)
Search Engine Demand Index10.37 (26.88)
Search Engine Supply Index2.00 (0.95)

This Compound (17.88)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other9 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
pd 98059
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one: inhibits MAP kinase kinase (MEK) activity, p42 MAPK and p44 MAPK; structure in first source. 2-(2-amino-3-methoxyphenyl)chromen-4-one : A member of the class of monomethoxyflavones that is 3'-methoxyflavone bearing an additional amino substituent at position 2'.		2.1710aromatic amine;
monomethoxyflavone		EC 2.7.11.24 (mitogen-activated protein kinase) inhibitor;
geroprotector
tetradecanoylphorbol acetate
Tetradecanoylphorbol Acetate: A phorbol ester found in CROTON OIL with very effective tumor promoting activity. It stimulates the synthesis of both DNA and RNA.. phorbol ester : Esters of phorbol, originally found in croton oil (from Croton tiglium, of the family Euphorbiaceae). A number of phorbol esters possess activity as tumour promoters and activate the mechanisms associated with cell growth. Some of these are used in experiments as activators of protein kinase C.. phorbol 13-acetate 12-myristate : A phorbol ester that is phorbol in which the hydroxy groups at the cyclopropane ring juction (position 13) and the adjacent carbon (position 12) have been converted into the corresponding acetate and myristate esters. It is a major active constituent of the seed oil of Croton tiglium. It has been used as a tumour promoting agent for skin carcinogenesis in rodents and is associated with increased cell proliferation of malignant cells. However its function is controversial since a decrease in cell proliferation has also been observed in several cancer cell types.		2.1310acetate ester;
diester;
phorbol ester;
tertiary alpha-hydroxy ketone;
tetradecanoate ester		antineoplastic agent;
apoptosis inducer;
carcinogenic agent;
mitogen;
plant metabolite;
protein kinase C agonist;
reactive oxygen species generator
glutamic acid
Glutamic Acid: A non-essential amino acid naturally occurring in the L-form. Glutamic acid is the most common excitatory neurotransmitter in the CENTRAL NERVOUS SYSTEM.. glutamic acid : An alpha-amino acid that is glutaric acid bearing a single amino substituent at position 2.		2.0710glutamic acid;
glutamine family amino acid;
L-alpha-amino acid;
proteinogenic amino acid		Escherichia coli metabolite;
ferroptosis inducer;
micronutrient;
mouse metabolite;
neurotransmitter;
nutraceutical
isoangustone a
isoangustone A: antioxidant isolated from Glycyrrhiza uralensis; structure in first source		2.0510isoflavanones
ConditionIndicatedRelationship StrengthStudiesTrials
B16 Melanoma
[description not available]		02.1710
Cancer of Liver
[description not available]		02.2110
Liver Neoplasms
Tumors or cancer of the LIVER.		02.2110
Innate Inflammatory Response
[description not available]		02.0810
Nervous System Disorders
[description not available]		02.0810
Inflammation
A pathological process characterized by injury or destruction of tissues caused by a variety of cytologic and chemical reactions. It is usually manifested by typical signs of pain, heat, redness, swelling, and loss of function.		07.0810
Nervous System Diseases
Diseases of the central and peripheral nervous system. This includes disorders of the brain, spinal cord, cranial nerves, peripheral nerves, nerve roots, autonomic nervous system, neuromuscular junction, and muscle.		02.0810
Cell Transformation, Neoplastic
Cell changes manifested by escape from control mechanisms, increased growth potential, alterations in the cell surface, karyotypic abnormalities, morphological and biochemical deviations from the norm, and other attributes conferring the ability to invade, metastasize, and kill.		02.1310
Atheroma
[description not available]		02.0810
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