dehydroglyasperin-c and Liver-Neoplasms

Glycyrrhiza (licorice) species are rich in bioactive secondary metabolites and their roots are used traditionally for the treatment of several diseases. In recent years, secondary metabolites of licorice are gaining popularity, especially due to their significant cytotoxic and antitumor effects. However, Glycyrrhiza iconica, an endemic species to Turkey, was not investigated in terms of its anticancer secondary metabolites previously.. This study aimed to isolate the cytotoxic compounds from G. iconica through bioactivity-guided fractionation and to elucidate mechanisms of action of the most potent compounds.. Total MeOH extract and CHCl. The results demonstrated that the aforementioned compounds, particularly 12 could be potential lead molecules for anticancer drug development that deserve further in vivo and clinical investigations.

Topics: Antioxidants; Apoptosis; Benzopyrans; Cell Cycle; Cell Line, Tumor; Glycyrrhiza; Humans; Liver Neoplasms; Phenols; Plant Extracts; Plant Roots