Assay ID | Title | Year | Journal | Article |
AID487820 | Antiproliferative activity against human A549 cells after 24 hrs by SRB assay | 2010 | Bioorganic & medicinal chemistry, Jun-15, Volume: 18, Issue:12
| Discovery of tetrahydro-beta-carbolines as inhibitors of the mitotic kinesin KSP. |
AID487824 | Antiproliferative activity against human PC3 cells after 24 hrs by SRB assay | 2010 | Bioorganic & medicinal chemistry, Jun-15, Volume: 18, Issue:12
| Discovery of tetrahydro-beta-carbolines as inhibitors of the mitotic kinesin KSP. |
AID537127 | Cytotoxicity against human A2780 cells after 72 hrs by MTT assay | 2010 | Bioorganic & medicinal chemistry, Nov-15, Volume: 18, Issue:22
| Design, synthesis and bioevaluation of dihydropyrazolo[3,4-b]pyridine and benzo[4,5]imidazo[1,2-a]pyrimidine compounds as dual KSP and Aurora-A kinase inhibitors for anti-cancer agents. |
AID614272 | Toxicity in mouse S180 cells xenografted ICR mouse assessed as change in body weight at 50 mg/kg, ip administered for 10 days every other day measured on day 11 (Rvb = 26.22 +/- 2.22 gram) | 2011 | Bioorganic & medicinal chemistry, Sep-15, Volume: 19, Issue:18
| De novo design, synthesis and biological evaluation of 1,4-dihydroquinolin-4-ones and 1,2,3,4-tetrahydroquinazolin-4-ones as potent kinesin spindle protein (KSP) inhibitors. |
AID614471 | Cytotoxicity against human A549 cells after 48 hrs by SRB assay | 2011 | Bioorganic & medicinal chemistry, Sep-15, Volume: 19, Issue:18
| De novo design, synthesis and biological evaluation of 1,4-dihydroquinolin-4-ones and 1,2,3,4-tetrahydroquinazolin-4-ones as potent kinesin spindle protein (KSP) inhibitors. |
AID614271 | Toxicity in ICR mouse administered as ip qd for 5 days | 2011 | Bioorganic & medicinal chemistry, Sep-15, Volume: 19, Issue:18
| De novo design, synthesis and biological evaluation of 1,4-dihydroquinolin-4-ones and 1,2,3,4-tetrahydroquinazolin-4-ones as potent kinesin spindle protein (KSP) inhibitors. |
AID537124 | Inhibition of human full-length Eg5 ATPase activity expressed in Escherichia coli assessed as release of inorganic phosphate after 30 mins | 2010 | Bioorganic & medicinal chemistry, Nov-15, Volume: 18, Issue:22
| Design, synthesis and bioevaluation of dihydropyrazolo[3,4-b]pyridine and benzo[4,5]imidazo[1,2-a]pyrimidine compounds as dual KSP and Aurora-A kinase inhibitors for anti-cancer agents. |
AID487821 | Antiproliferative activity against human AGS cells after 24 hrs by SRB assay | 2010 | Bioorganic & medicinal chemistry, Jun-15, Volume: 18, Issue:12
| Discovery of tetrahydro-beta-carbolines as inhibitors of the mitotic kinesin KSP. |
AID614472 | Cytotoxicity against human AGS cells after 48 hrs by SRB assay | 2011 | Bioorganic & medicinal chemistry, Sep-15, Volume: 19, Issue:18
| De novo design, synthesis and biological evaluation of 1,4-dihydroquinolin-4-ones and 1,2,3,4-tetrahydroquinazolin-4-ones as potent kinesin spindle protein (KSP) inhibitors. |
AID487823 | Antiproliferative activity against human HT-29 cells after 24 hrs by SRB assay | 2010 | Bioorganic & medicinal chemistry, Jun-15, Volume: 18, Issue:12
| Discovery of tetrahydro-beta-carbolines as inhibitors of the mitotic kinesin KSP. |
AID614275 | Antitumor activity against mouse S180 cells xenografted in ICR mouse assessed as tumor growth inhibition at 50 mg/kg, ip administered for 10 days every other day measured on day 11 relative to control | 2011 | Bioorganic & medicinal chemistry, Sep-15, Volume: 19, Issue:18
| De novo design, synthesis and biological evaluation of 1,4-dihydroquinolin-4-ones and 1,2,3,4-tetrahydroquinazolin-4-ones as potent kinesin spindle protein (KSP) inhibitors. |
AID537128 | Cytotoxicity against human HepG2 cells after 72 hrs by MTT assay | 2010 | Bioorganic & medicinal chemistry, Nov-15, Volume: 18, Issue:22
| Design, synthesis and bioevaluation of dihydropyrazolo[3,4-b]pyridine and benzo[4,5]imidazo[1,2-a]pyrimidine compounds as dual KSP and Aurora-A kinase inhibitors for anti-cancer agents. |
AID487822 | Antiproliferative activity against human HepG2 cells after 24 hrs by SRB assay | 2010 | Bioorganic & medicinal chemistry, Jun-15, Volume: 18, Issue:12
| Discovery of tetrahydro-beta-carbolines as inhibitors of the mitotic kinesin KSP. |
AID487602 | Inhibition of human Eg5 expressed in Escherichia coli assessed as microtubule-activated ATPase activity by spectrophotometry | 2010 | Bioorganic & medicinal chemistry, Jun-15, Volume: 18, Issue:12
| Discovery of tetrahydro-beta-carbolines as inhibitors of the mitotic kinesin KSP. |
AID614470 | Inhibition of human ATPase activity KSP expressed in Escherichia coli after 30 mins by spectrophotometric analysis | 2011 | Bioorganic & medicinal chemistry, Sep-15, Volume: 19, Issue:18
| De novo design, synthesis and biological evaluation of 1,4-dihydroquinolin-4-ones and 1,2,3,4-tetrahydroquinazolin-4-ones as potent kinesin spindle protein (KSP) inhibitors. |
AID537126 | Cytotoxicity against human HCT116 cells after 72 hrs by MTT assay | 2010 | Bioorganic & medicinal chemistry, Nov-15, Volume: 18, Issue:22
| Design, synthesis and bioevaluation of dihydropyrazolo[3,4-b]pyridine and benzo[4,5]imidazo[1,2-a]pyrimidine compounds as dual KSP and Aurora-A kinase inhibitors for anti-cancer agents. |
AID537125 | Inhibition of human purified recombinant aurora-A kinase | 2010 | Bioorganic & medicinal chemistry, Nov-15, Volume: 18, Issue:22
| Design, synthesis and bioevaluation of dihydropyrazolo[3,4-b]pyridine and benzo[4,5]imidazo[1,2-a]pyrimidine compounds as dual KSP and Aurora-A kinase inhibitors for anti-cancer agents. |
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |