Compounds > caldopentamine
Page last updated: 2024-12-07

caldopentamine

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

Caldopentamine is a synthetic, non-peptide, orally active, potent, and selective agonist for the δ-opioid receptor. It has shown promise in preclinical studies for the treatment of neuropathic pain, but it has not yet been approved for clinical use. The compound was developed based on the structure of the naturally occurring opioid peptide deltorphin. Caldopentamine is a potent analgesic and has been shown to be effective in reducing pain in animal models of neuropathic pain. It is also thought to have anti-inflammatory properties. Caldopentamine is being studied for its potential to treat various pain conditions, including chronic pain, inflammatory pain, and neuropathic pain.'

caldopentamine: from cells of extreme thermophile, Thermus thermophilus, grown at 80 degrees Celcius [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

caldopentamine : A polyazaalkane that is the 1,5,9,13,17-pentaaza derivative of heptodecane. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Cross-References

ID SourceID
PubMed CID83290
CHEBI ID83546
SCHEMBL ID561809
MeSH IDM0108960

Synonyms (24)

Synonym
13274-42-5
caldopentamine
n-(3-aminopropyl)-n'-(3-((3-aminopropyl)amino)propyl)propane-1,3-diamine
1,3-propanediamine, n-(3-aminopropyl)-n'-(3-((3-aminopropyl)amino)propyl)-
tetratrimethylenepentamine
tetrapropylenepentamine
einecs 236-272-4
n-(3-aminopropyl)-n'-(3-((3-aminopropyl)amino)propyl)-1,3-propanediamine
n-(3-aminopropyl)-n'-{3-[(3-aminopropyl)amino]propyl}propane-1,3-diamine
n'-[3-[3-(3-aminopropylamino)propylamino]propyl]propane-1,3-diamine
dipropylamine, 3,3'-bis((3-(aminopropyl))amino)-
1,3-propanediamine, n1-(3-aminopropyl)-n3-(3-((3-aminopropyl)amino)propyl)-
1,15-diamino-4,8,12-triazapentadecane
1,3-propanediamine, n-(3-aminopropyl)-n'-[3-[(3-aminopropyl)amino]propyl]-
SCHEMBL561809
CHEBI:83546
DTXSID1065392
n-(3-aminopropyl)-n'-{3-[(3-aminopropyl)amino]propyl}-1,3-propanediamine
C21100
n-(3-aminopropyl)-n-[3-[(3-aminopropyl)amino]propyl]propane-1,3-diamine
Q27156940
n1-(3-aminopropyl)-n3-(3-((3-aminopropyl)amino)propyl)propane-1,3-diamine
4,4-bis(3-aminopropyl)-1,7-diamino-4-azaheptane
n-(3-aminopropyl)-n/'-[3-[(3-aminopropyl)amino]propyl]propane-1,3-diamine
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Roles (1)

RoleDescription
marine metaboliteAny metabolite produced during a metabolic reaction in marine macro- and microorganisms.
[role information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Drug Classes (3)

ClassDescription
polyazaalkaneAny azaalkane in which two or more carbons in the chain are replaced by nitrogen.
primary amino compoundA compound formally derived from ammonia by replacing one hydrogen atom by an organyl group.
secondary amino compoundA compound formally derived from ammonia by replacing two hydrogen atoms by organyl groups.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Research

Studies (9)

TimeframeStudies, This Drug (%)All Drugs %
pre-19902 (22.22)18.7374
1990's0 (0.00)18.2507
2000's4 (44.44)29.6817
2010's2 (22.22)24.3611
2020's1 (11.11)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.07

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.07 (24.57)
Research Supply Index2.30 (2.92)
Research Growth Index4.37 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.07)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews1 (11.11%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other8 (88.89%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
sym-homospermidine
sym-homospermidine: analog of spermidine isolated from sandal leaves (Santalum album L.); structure. sym-homospermidine : A polyazaalkane comprising undecane with three aza groups placed at the 1-, 6- and 11-positions.		2.0610polyazaalkane;
triamine
putrescine
[no description available]		2.610alkane-alpha,omega-diamineantioxidant;
fundamental metabolite
spermidine
[no description available]		2.7930polyazaalkane;
triamine		autophagy inducer;
fundamental metabolite;
geroprotector
spermine
[no description available]		2.9640polyazaalkane;
tetramine		antioxidant;
fundamental metabolite;
immunosuppressive agent
arginine
Arginine: An essential amino acid that is physiologically active in the L-form.. arginine : An alpha-amino acid that is glycine in which the alpha-is substituted by a 3-guanidinopropyl group.		3.1310arginine;
glutamine family amino acid;
L-alpha-amino acid;
proteinogenic amino acid		biomarker;
Escherichia coli metabolite;
micronutrient;
mouse metabolite;
nutraceutical
pentamine
pentamine: RN given refers to parent cpd; structure in Merck		2.0510
thermospermine
thermospermine: polyamine extracted from an extreme thermopile, Thermus thermophilus; structure. thermospermine : Propane-1,3-diamine in which a hydrogen attached to one nitrogen is substituted by a 3-aminoprop-1-yl group, and a hydrogen attached to the other nitrogen is substituted by a 4-aminobut-1-yl group. A polyamine natural product, its name arises from its similarity to spermine and the fact that it was first isolated from the extreme thermophile, Thermus thermophilus.		2.0610polyazaalkane;
tetramine
homocaldopentamine
homocaldopentamine: from extreme thermophile Thermus thermophilus; structure given in first source		7.9440
tetrakis(3-aminopropyl)ammonium
tetrakis(3-aminopropyl)ammonium: from Thermus thermophilus ; structure given in first source		3.8430
ConditionIndicatedRelationship StrengthStudiesTrials