| Substance | Relationship Strength | Studies | Trials | Classes | Roles |
|---|
3-methylcholanthrene
Methylcholanthrene: A carcinogen that is often used in experimental cancer studies.. 3-methylcholanthrene : A pentacyclic ortho- and peri-fused polycyclic arene consisting of a dihydrocyclopenta[ij]tetraphene ring system with a methyl substituent at the 3-position. | 1.95 | 1 | 0 | ortho- and peri-fused polycyclic arene | aryl hydrocarbon receptor agonist;
carcinogenic agent |
benzo(a)pyrene
Benzo(a)pyrene: A potent mutagen and carcinogen. It is a public health concern because of its possible effects on industrial workers, as an environmental pollutant, an as a component of tobacco smoke.. benzo[a]pyrene : An ortho- and peri-fused polycyclic arene consisting of five fused benzene rings. | 2.66 | 3 | 0 | ortho- and peri-fused polycyclic arene | carcinogenic agent;
mouse metabolite |
phenobarbital
Phenobarbital: A barbituric acid derivative that acts as a nonselective central nervous system depressant. It potentiates GAMMA-AMINOBUTYRIC ACID action on GABA-A RECEPTORS, and modulates chloride currents through receptor channels. It also inhibits glutamate induced depolarizations.. phenobarbital : A member of the class of barbiturates, the structure of which is that of barbituric acid substituted at C-5 by ethyl and phenyl groups. | 1.95 | 1 | 0 | barbiturates | anticonvulsant;
drug allergen;
excitatory amino acid antagonist;
sedative |
styrene oxide
styrene oxide: structure. styrene oxide : An epoxide that is oxirane in which one of the hydrogens has been replaced by a phenyl group. | 2.01 | 1 | 0 | epoxide | human xenobiotic metabolite |
benzo(a)pyrene 7,8-dihydrodiol
benzo(a)pyrene 7,8-dihydrodiol: RN given refers to cpd without isomeric designation | 2.88 | 4 | 0 | pyrenes | |
7,8-dihydrobenzo(a)pyrene
7,8-dihydrobenzo(a)pyrene: structure given in first source | 1.95 | 1 | 0 | | |
6-hydroxybenzo(a)pyrene
6-hydroxybenzo(a)pyrene: RN given refers to parent cpd; structure in first source | 1.95 | 1 | 0 | ortho- and peri-fused polycyclic arene | |
benzo(a)pyrene 4,5-epoxide
benzo(a)pyrene 4,5-epoxide: RN given refers to cpd with unspecifiedisomeric designation | 2.65 | 3 | 0 | carbopolycyclic compound | |
7,8-dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide
7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide: 7,8,8a,9a-Tetrahydrobenzo(10,11)chryseno (3,4-b)oxirene-7,8-diol. A benzopyrene derivative with carcinogenic and mutagenic activity. | 2.36 | 2 | 0 | epoxide | intercalator |
2-hydroxybenzo(a)pyrene
2-hydroxybenzo(a)pyrene: RN given refers to parent cpd; structure in first source | 1.95 | 1 | 0 | ortho- and peri-fused polycyclic arene | |
riboflavin
vitamin B2 : Any member of a group of vitamers that belong to the chemical structural class called flavins that exhibit biological activity against vitamin B2 deficiency. Symptoms associated with vitamin B2 deficiency include glossitis, seborrhea, angular stomaitis, cheilosis and photophobia. The vitamers include riboflavin and its phosphate derivatives (and includes their salt, ionised and hydrate forms). | 1.95 | 1 | 0 | flavin;
vitamin B2 | anti-inflammatory agent;
antioxidant;
cofactor;
Escherichia coli metabolite;
food colouring;
fundamental metabolite;
human urinary metabolite;
mouse metabolite;
photosensitizing agent;
plant metabolite |
9,10-epoxy-7,8,9,10-tetrahydrobenzo(a)pyrene
9,10-epoxy-7,8,9,10-tetrahydrobenzo(a)pyrene: RN given refers to cpd with unspecified isomeric designation; structure given in first source | 1.95 | 1 | 0 | | |