averantin: aflatoxin B(1) precursor; structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
averantin : A tetrahydroxyanthraquinone that is 1,3,6,8-tetrahydroxy-9,10-anthraquinone bearing a 1-hydroxyhexyl substituent at position 2. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]
(S)-averantin : An optically active form of averantin having S-configuration. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]
| ID Source | ID |
|---|---|
| PubMed CID | 10044783 |
| CHEMBL ID | 2071288 |
| CHEBI ID | 71534 |
| SCHEMBL ID | 23199049 |
| MeSH ID | M0083442 |
| Synonym |
|---|
| 9,10-anthracenedione, 1,3,6,8-tetrahydroxy-2-(1-hydroxyhexyl)-, (-)- |
| averantin |
| anthraquinone, 1,3,6,8-tetrahydroxy-2-(1-hydroxyhexyl)- |
| 2-(1-hydroxyhexyl)-1,3,6,8-tetrahydroxyanthraquinone |
| anthraquinone, 2-(1-hydroxyhexyl)-1,3,6,8-tetrahydroxy- |
| brn 2309929 |
| 1,3,6,8-tetrahydroxy-[(1s)-2-hydroxyhexyl]-9,10-anthraquinone |
| (1's)-averantin |
| 6h95d7020n , |
| (-)-averantin |
| 4-08-00-03734 (beilstein handbook reference) |
| unii-6h95d7020n |
| 5803-62-3 |
| C20499 |
| (s)-(-)-averantin |
| 1,3,6,8-tetrahydroxy-2-[(1s)-1-hydroxyhexyl]-9,10-anthraquinone |
| (s)-averantin |
| CHEMBL2071288 |
| CHEBI:71534 , |
| 1,3,6,8-tetrahydroxy-2-((1s)-1-hydroxyhexyl)-9,10-anthracenedione |
| 9,10-anthracenedione, 1,3,6,8-tetrahydroxy-2-((1s)-1-hydroxyhexyl)- |
| averantin, (-)- |
| SCHEMBL23199049 |
| Q27139690 |
| 1,3,6,8-tetrahydroxy-2-[(1s)-1-hydroxyhexyl]anthracene-9,10-dione |
| CS-0077221 |
| HY-119663 |
| AKOS040762808 |
| (s)-1,3,6,8-tetrahydroxy-2-(1-hydroxyhexyl)-anthracene-9,10-dione |
| Class | Description |
|---|---|
| averantin | A tetrahydroxyanthraquinone that is 1,3,6,8-tetrahydroxy-9,10-anthraquinone bearing a 1-hydroxyhexyl substituent at position 2. |
| [compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res] | |
| Assay ID | Title | Year | Journal | Article |
|---|---|---|---|---|
| AID1202750 | Induction of p53-dependent growth suppression of human LNZTA3 cells after 72 hrs by MTT assay | 2015 | Journal of natural products, Feb-27, Volume: 78, Issue:2 | Quinofuracins A-E, produced by the fungus Staphylotrichum boninense PF1444, show p53-dependent growth suppression. |
| AID678034 | Cytotoxicity against human NCI-H460 cells after 72 hrs BY SRB assay | 2012 | Journal of natural products, Jul-27, Volume: 75, Issue:7 | Halogenated anthraquinones from the marine-derived fungus Aspergillus sp. SCSIO F063. |
| AID678032 | Cytotoxicity against human SF268 cells after 72 hrs BY SRB assay | 2012 | Journal of natural products, Jul-27, Volume: 75, Issue:7 | Halogenated anthraquinones from the marine-derived fungus Aspergillus sp. SCSIO F063. |
| AID678033 | Cytotoxicity against human MCF7 cells after 72 hrs BY SRB assay | 2012 | Journal of natural products, Jul-27, Volume: 75, Issue:7 | Halogenated anthraquinones from the marine-derived fungus Aspergillus sp. SCSIO F063. |
| AID678036 | Antimicrobial activity against Bacillus thuringiensis ATCC 39765 assessed as diameter of zone of growth inhibition at 10 ug/6 mm disc incubated for 12 hrs by disc diffusion assay | 2012 | Journal of natural products, Jul-27, Volume: 75, Issue:7 | Halogenated anthraquinones from the marine-derived fungus Aspergillus sp. SCSIO F063. |
| AID678035 | Antimicrobial activity against Staphylococcus aureus ATCC 29213 assessed as diameter of zone of growth inhibition at 10 ug/6 mm disc incubated for 12 hrs by disc diffusion assay | 2012 | Journal of natural products, Jul-27, Volume: 75, Issue:7 | Halogenated anthraquinones from the marine-derived fungus Aspergillus sp. SCSIO F063. |
| AID678037 | Antimicrobial activity against Bacillus subtilis ATCC 6633 assessed as diameter of zone of growth inhibition at 10 ug/6 mm disc incubated for 12 hrs by disc diffusion assay | 2012 | Journal of natural products, Jul-27, Volume: 75, Issue:7 | Halogenated anthraquinones from the marine-derived fungus Aspergillus sp. SCSIO F063. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||||
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|---|---|
| pre-1990 | 2 (15.38) | 18.7374 |
| 1990's | 2 (15.38) | 18.2507 |
| 2000's | 3 (23.08) | 29.6817 |
| 2010's | 5 (38.46) | 24.3611 |
| 2020's | 1 (7.69) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
| Publication Type | This drug (%) | All Drugs (%) |
|---|---|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 0 (0.00%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 13 (100.00%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||