armeniaspirol-a and Helicobacter-Infections

Antibiotic resistance in Helicobacter pylori has been growing worldwide with current treatment regimens. Development of new compounds for treatment of H. pylori infections is urgently required to achieve a successful eradication therapy in the future. Armeniaspirols, a novel class of natural products isolated from Streptomyces armeniacus, have been previously identified as antibacterial agents against Gram-positive pathogens. In this study, we found that armeniaspirol A (ARM1) exhibited potent antibacterial activity against H. pylori, including multidrug-resistant strains, with MIC range values of 4-16 μg ml

Topics: Animals; Anti-Bacterial Agents; Helicobacter Infections; Helicobacter pylori; Metronidazole; Mice; Pyrroles; Spiro Compounds