Page last updated: 2024-12-05
4-n-bis(2-chloroethyl)aminobenzoic acid
Description
Research Excerpts
Clinical Trials
Roles
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Pathways
Study Profile
Bioassays
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Research Growth
Market Indicators
Description
4-N-bis(2-chloroethyl)aminobenzoic acid: structure given in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
Cross-References
ID Source | ID |
---|---|
PubMed CID | 14356 |
CHEMBL ID | 12293 |
SCHEMBL ID | 766052 |
MeSH ID | M0163591 |
Synonyms (24)
Synonym |
---|
benzoic acid, p-[bis(2-chloroethyl)amino]- |
nsc-26276 |
4-[bis(2-chloroethyl)amino]benzoic acid |
wln: qvr dn2g2g |
benzoic acid, 4-[bis(2-chloroethyl)amino]- |
nsc26276 |
1141-37-3 |
benzoic acid nitrogen mustard |
benzoic acid, p-(bis(2-chloroethyl)amino)- |
brn 0988858 |
4-n-bis(2-chloroethyl)aminobenzoic acid |
nsc 26276 |
4-(bis(2-chloroethyl)amino)benzoic acid |
benzoic acid, 4-(bis(2-chloroethyl)amino)- |
p-n,n-bis(2-chloroethyl)aminobenzoic acid |
CHEMBL12293 |
kd3azx3r33 , |
unii-kd3azx3r33 |
4-[bis-(2-chloroethyl)amino] benzoic acid |
SCHEMBL766052 |
DTXSID40150654 |
4-[bis(2-chloroethyl)amino] benzoic acid |
p-(bis(2-chloroethyl)amino)benzoic acid |
4-[bis-(2-chloroethyl)amino]benzoic acid |
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
Bioassays (37)
Assay ID | Title | Year | Journal | Article |
---|---|---|---|---|
AID1132020 | Antitumor activity against rat Walker 256 cells allografted in rat | 1978 | Journal of medicinal chemistry, Jan, Volume: 21, Issue:1 | Structure-activity relationships in antitumor aniline mustards. |
AID1421496 | Cytotoxicity against human LO2 cells assessed as decrease in cell viability after 72 hrs by MTT assay | 2018 | European journal of medicinal chemistry, Oct-05, Volume: 158 | Synthesis of scutellarein derivatives with antiproliferative activity and selectivity through the intrinsic pathway. |
AID1383599 | Selectivity index, ratio of IC50 for human LO2 cells to IC50 for human Bel7402 cells | 2018 | European journal of medicinal chemistry, Apr-25, Volume: 150 | Novel hybrids of brefeldin A and nitrogen mustards with improved antiproliferative selectivity: Design, synthesis and antitumor biological evaluation. |
AID1421495 | Antiproliferative activity against human Bel7402 cells after 72 hrs by MTT assay | 2018 | European journal of medicinal chemistry, Oct-05, Volume: 158 | Synthesis of scutellarein derivatives with antiproliferative activity and selectivity through the intrinsic pathway. |
AID24282 | Chemical half-life in percholate at 37 degree was determined | 1994 | Journal of medicinal chemistry, Jul-22, Volume: 37, Issue:15 | Novel prodrugs of alkylating agents derived from 2-fluoro- and 3-fluorobenzoic acids for antibody-directed enzyme prodrug therapy. |
AID1393842 | Antiproliferative activity against human HL60 cells after 72 hrs by MTT assay | 2018 | European journal of medicinal chemistry, Feb-25, Volume: 146 | Novel enmein-type diterpenoid hybrids coupled with nitrogen mustards: Synthesis of promising candidates for anticancer therapeutics. |
AID1777556 | Antiproliferative activity against human MCF7 cells assessed as inhibition of cell proliferation measured after 72 hrs by CCK-8 assay | 2021 | Bioorganic & medicinal chemistry, 09-01, Volume: 45 | Design and synthesis of β-carboline derivatives with nitrogen mustard moieties against breast cancer. |
AID1421494 | Antiproliferative activity against human MCF7 cells after 72 hrs by MTT assay | 2018 | European journal of medicinal chemistry, Oct-05, Volume: 158 | Synthesis of scutellarein derivatives with antiproliferative activity and selectivity through the intrinsic pathway. |
AID1465329 | Antiproliferative activity against human PC3 cells treated for 24 hrs measured after 72 hrs by MTT assay | 2017 | Bioorganic & medicinal chemistry letters, 11-15, Volume: 27, Issue:22 | Design and synthesis of novel nitrogen mustard-evodiamine hybrids with selective antiproliferative activity. |
AID1777558 | Cytotoxicity against human MCF-10A cells assessed as inhibition of cell proliferation measured after 72 hrs by CCK-8 assay | 2021 | Bioorganic & medicinal chemistry, 09-01, Volume: 45 | Design and synthesis of β-carboline derivatives with nitrogen mustard moieties against breast cancer. |
AID1777557 | Antiproliferative activity against human MDA-MB-231 cells assessed as inhibition of cell proliferation measured after 72 hrs by CCK-8 assay | 2021 | Bioorganic & medicinal chemistry, 09-01, Volume: 45 | Design and synthesis of β-carboline derivatives with nitrogen mustard moieties against breast cancer. |
AID1393843 | Antiproliferative activity against human PC3 cells after 72 hrs by MTT assay | 2018 | European journal of medicinal chemistry, Feb-25, Volume: 146 | Novel enmein-type diterpenoid hybrids coupled with nitrogen mustards: Synthesis of promising candidates for anticancer therapeutics. |
AID102183 | Inhibitory concentration was evaluated against colorectal tumar cell line LoVo | 1996 | Journal of medicinal chemistry, Mar-01, Volume: 39, Issue:5 | New mustard prodrugs for antibody-directed enzyme prodrug therapy: alternatives to the amide link. |
AID1185080 | Antiproliferative activity against human MCF7 cells assessed as growth inhibition after 72 hrs by MTT assay | 2014 | ACS medicinal chemistry letters, Jul-10, Volume: 5, Issue:7 | Novel hybrids of natural oridonin-bearing nitrogen mustards as potential anticancer drug candidates. |
AID1465331 | Antiproliferative activity against human THP1 cells treated for 24 hrs measured after 72 hrs by MTT assay | 2017 | Bioorganic & medicinal chemistry letters, 11-15, Volume: 27, Issue:22 | Design and synthesis of novel nitrogen mustard-evodiamine hybrids with selective antiproliferative activity. |
AID1185082 | Antiproliferative activity against human MGC803 cells assessed as growth inhibition after 72 hrs by MTT assay | 2014 | ACS medicinal chemistry letters, Jul-10, Volume: 5, Issue:7 | Novel hybrids of natural oridonin-bearing nitrogen mustards as potential anticancer drug candidates. |
AID91909 | The compound was tested for cytotoxicity against human JAR, choriocarcinoma cell line. | 1990 | Journal of medicinal chemistry, Feb, Volume: 33, Issue:2 | Novel prodrugs which are activated to cytotoxic alkylating agents by carboxypeptidase G2. |
AID1383594 | Antiproliferative activity against human HL60 cells after 72 hrs by MTT assay | 2018 | European journal of medicinal chemistry, Apr-25, Volume: 150 | Novel hybrids of brefeldin A and nitrogen mustards with improved antiproliferative selectivity: Design, synthesis and antitumor biological evaluation. |
AID1185079 | Antiproliferative activity against human K562 cells assessed as growth inhibition after 72 hrs by MTT assay | 2014 | ACS medicinal chemistry letters, Jul-10, Volume: 5, Issue:7 | Novel hybrids of natural oridonin-bearing nitrogen mustards as potential anticancer drug candidates. |
AID1393846 | Antiproliferative activity against human LO2 cells after 72 hrs by MTT assay | 2018 | European journal of medicinal chemistry, Feb-25, Volume: 146 | Novel enmein-type diterpenoid hybrids coupled with nitrogen mustards: Synthesis of promising candidates for anticancer therapeutics. |
AID1185088 | Cytotoxicity against human L02 cells by MTT assay | 2014 | ACS medicinal chemistry letters, Jul-10, Volume: 5, Issue:7 | Novel hybrids of natural oridonin-bearing nitrogen mustards as potential anticancer drug candidates. |
AID1393847 | Selectivity index, ratio of IC50 for human LO2 cells to IC50 for human Bel7402 cells | 2018 | European journal of medicinal chemistry, Feb-25, Volume: 146 | Novel enmein-type diterpenoid hybrids coupled with nitrogen mustards: Synthesis of promising candidates for anticancer therapeutics. |
AID101135 | The compound was tested for cytotoxicity against human LS174T,colorectal cell line. | 1990 | Journal of medicinal chemistry, Feb, Volume: 33, Issue:2 | Novel prodrugs which are activated to cytotoxic alkylating agents by carboxypeptidase G2. |
AID1383598 | Antiproliferative activity against human LO2 cells after 72 hrs by MTT assay | 2018 | European journal of medicinal chemistry, Apr-25, Volume: 150 | Novel hybrids of brefeldin A and nitrogen mustards with improved antiproliferative selectivity: Design, synthesis and antitumor biological evaluation. |
AID1465330 | Antiproliferative activity against human HepG2 cells treated for 24 hrs measured after 72 hrs by MTT assay | 2017 | Bioorganic & medicinal chemistry letters, 11-15, Volume: 27, Issue:22 | Design and synthesis of novel nitrogen mustard-evodiamine hybrids with selective antiproliferative activity. |
AID1465332 | Antiproliferative activity against human HL60 cells treated for 24 hrs measured after 72 hrs by MTT assay | 2017 | Bioorganic & medicinal chemistry letters, 11-15, Volume: 27, Issue:22 | Design and synthesis of novel nitrogen mustard-evodiamine hybrids with selective antiproliferative activity. |
AID1383595 | Antiproliferative activity against human PC3 cells after 72 hrs by MTT assay | 2018 | European journal of medicinal chemistry, Apr-25, Volume: 150 | Novel hybrids of brefeldin A and nitrogen mustards with improved antiproliferative selectivity: Design, synthesis and antitumor biological evaluation. |
AID1185087 | Anticancer activity against human Bel7402 cells assessed as growth inhibition by MTT assay | 2014 | ACS medicinal chemistry letters, Jul-10, Volume: 5, Issue:7 | Novel hybrids of natural oridonin-bearing nitrogen mustards as potential anticancer drug candidates. |
AID1060756 | Antitumor activity against mouse B16F10 cells xenografted in C57BL/6 mouse assessed as reduction of tumor size at 100 ug administered as intratumorally for 3 days | 2014 | European journal of medicinal chemistry, Jan, Volume: 71 | Synthesis and analysis of activity of a potential anti-melanoma prodrug with a hydrazine linker. |
AID1393845 | Antiproliferative activity against human Bel7402/5-FU cells after 72 hrs by MTT assay | 2018 | European journal of medicinal chemistry, Feb-25, Volume: 146 | Novel enmein-type diterpenoid hybrids coupled with nitrogen mustards: Synthesis of promising candidates for anticancer therapeutics. |
AID1383597 | Antiproliferative activity against human Bel7402/5-FU cells after 72 hrs by MTT assay | 2018 | European journal of medicinal chemistry, Apr-25, Volume: 150 | Novel hybrids of brefeldin A and nitrogen mustards with improved antiproliferative selectivity: Design, synthesis and antitumor biological evaluation. |
AID1421493 | Antiproliferative activity against human A549 cells after 72 hrs by MTT assay | 2018 | European journal of medicinal chemistry, Oct-05, Volume: 158 | Synthesis of scutellarein derivatives with antiproliferative activity and selectivity through the intrinsic pathway. |
AID1383596 | Antiproliferative activity against human Bel7402 cells after 72 hrs by MTT assay | 2018 | European journal of medicinal chemistry, Apr-25, Volume: 150 | Novel hybrids of brefeldin A and nitrogen mustards with improved antiproliferative selectivity: Design, synthesis and antitumor biological evaluation. |
AID1465333 | Antiproliferative activity against human PBMC treated for 24 hrs measured after 72 hrs by MTT assay | 2017 | Bioorganic & medicinal chemistry letters, 11-15, Volume: 27, Issue:22 | Design and synthesis of novel nitrogen mustard-evodiamine hybrids with selective antiproliferative activity. |
AID1132021 | Toxicity in rat allografted with rat Walker 256 cells | 1978 | Journal of medicinal chemistry, Jan, Volume: 21, Issue:1 | Structure-activity relationships in antitumor aniline mustards. |
AID1185081 | Antiproliferative activity against human Bel7402 cells assessed as growth inhibition after 72 hrs by MTT assay | 2014 | ACS medicinal chemistry letters, Jul-10, Volume: 5, Issue:7 | Novel hybrids of natural oridonin-bearing nitrogen mustards as potential anticancer drug candidates. |
AID1393844 | Antiproliferative activity against human Bel7402 cells after 72 hrs by MTT assay | 2018 | European journal of medicinal chemistry, Feb-25, Volume: 146 | Novel enmein-type diterpenoid hybrids coupled with nitrogen mustards: Synthesis of promising candidates for anticancer therapeutics. |
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |
Research
Studies (13)
Timeframe | Studies, This Drug (%) | All Drugs % |
---|---|---|
pre-1990 | 2 (15.38) | 18.7374 |
1990's | 4 (30.77) | 18.2507 |
2000's | 0 (0.00) | 29.6817 |
2010's | 6 (46.15) | 24.3611 |
2020's | 1 (7.69) | 2.80 |
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] |
Market Indicators
Research Demand Index: 11.92
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.
| This Compound (11.92) All Compounds (24.57) |
Study Types
Publication Type | This drug (%) | All Drugs (%) |
---|---|---|
Trials | 0 (0.00%) | 5.53% |
Reviews | 0 (0.00%) | 6.00% |
Case Studies | 0 (0.00%) | 4.05% |
Observational | 0 (0.00%) | 0.25% |
Other | 13 (100.00%) | 84.16% |
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] |