| Assay ID | Title | Year | Journal | Article |
|---|
| AID1132020 | Antitumor activity against rat Walker 256 cells allografted in rat | 1978 | Journal of medicinal chemistry, Jan, Volume: 21, Issue:1
| Structure-activity relationships in antitumor aniline mustards. |
| AID1421496 | Cytotoxicity against human LO2 cells assessed as decrease in cell viability after 72 hrs by MTT assay | 2018 | European journal of medicinal chemistry, Oct-05, Volume: 158 | Synthesis of scutellarein derivatives with antiproliferative activity and selectivity through the intrinsic pathway. |
| AID1383599 | Selectivity index, ratio of IC50 for human LO2 cells to IC50 for human Bel7402 cells | 2018 | European journal of medicinal chemistry, Apr-25, Volume: 150 | Novel hybrids of brefeldin A and nitrogen mustards with improved antiproliferative selectivity: Design, synthesis and antitumor biological evaluation. |
| AID1421495 | Antiproliferative activity against human Bel7402 cells after 72 hrs by MTT assay | 2018 | European journal of medicinal chemistry, Oct-05, Volume: 158 | Synthesis of scutellarein derivatives with antiproliferative activity and selectivity through the intrinsic pathway. |
| AID24282 | Chemical half-life in percholate at 37 degree was determined | 1994 | Journal of medicinal chemistry, Jul-22, Volume: 37, Issue:15
| Novel prodrugs of alkylating agents derived from 2-fluoro- and 3-fluorobenzoic acids for antibody-directed enzyme prodrug therapy. |
| AID1393842 | Antiproliferative activity against human HL60 cells after 72 hrs by MTT assay | 2018 | European journal of medicinal chemistry, Feb-25, Volume: 146 | Novel enmein-type diterpenoid hybrids coupled with nitrogen mustards: Synthesis of promising candidates for anticancer therapeutics. |
| AID1777556 | Antiproliferative activity against human MCF7 cells assessed as inhibition of cell proliferation measured after 72 hrs by CCK-8 assay | 2021 | Bioorganic & medicinal chemistry, 09-01, Volume: 45 | Design and synthesis of β-carboline derivatives with nitrogen mustard moieties against breast cancer. |
| AID1421494 | Antiproliferative activity against human MCF7 cells after 72 hrs by MTT assay | 2018 | European journal of medicinal chemistry, Oct-05, Volume: 158 | Synthesis of scutellarein derivatives with antiproliferative activity and selectivity through the intrinsic pathway. |
| AID1465329 | Antiproliferative activity against human PC3 cells treated for 24 hrs measured after 72 hrs by MTT assay | 2017 | Bioorganic & medicinal chemistry letters, 11-15, Volume: 27, Issue:22
| Design and synthesis of novel nitrogen mustard-evodiamine hybrids with selective antiproliferative activity. |
| AID1777558 | Cytotoxicity against human MCF-10A cells assessed as inhibition of cell proliferation measured after 72 hrs by CCK-8 assay | 2021 | Bioorganic & medicinal chemistry, 09-01, Volume: 45 | Design and synthesis of β-carboline derivatives with nitrogen mustard moieties against breast cancer. |
| AID1777557 | Antiproliferative activity against human MDA-MB-231 cells assessed as inhibition of cell proliferation measured after 72 hrs by CCK-8 assay | 2021 | Bioorganic & medicinal chemistry, 09-01, Volume: 45 | Design and synthesis of β-carboline derivatives with nitrogen mustard moieties against breast cancer. |
| AID1393843 | Antiproliferative activity against human PC3 cells after 72 hrs by MTT assay | 2018 | European journal of medicinal chemistry, Feb-25, Volume: 146 | Novel enmein-type diterpenoid hybrids coupled with nitrogen mustards: Synthesis of promising candidates for anticancer therapeutics. |
| AID102183 | Inhibitory concentration was evaluated against colorectal tumar cell line LoVo | 1996 | Journal of medicinal chemistry, Mar-01, Volume: 39, Issue:5
| New mustard prodrugs for antibody-directed enzyme prodrug therapy: alternatives to the amide link. |
| AID1185080 | Antiproliferative activity against human MCF7 cells assessed as growth inhibition after 72 hrs by MTT assay | 2014 | ACS medicinal chemistry letters, Jul-10, Volume: 5, Issue:7
| Novel hybrids of natural oridonin-bearing nitrogen mustards as potential anticancer drug candidates. |
| AID1465331 | Antiproliferative activity against human THP1 cells treated for 24 hrs measured after 72 hrs by MTT assay | 2017 | Bioorganic & medicinal chemistry letters, 11-15, Volume: 27, Issue:22
| Design and synthesis of novel nitrogen mustard-evodiamine hybrids with selective antiproliferative activity. |
| AID1185082 | Antiproliferative activity against human MGC803 cells assessed as growth inhibition after 72 hrs by MTT assay | 2014 | ACS medicinal chemistry letters, Jul-10, Volume: 5, Issue:7
| Novel hybrids of natural oridonin-bearing nitrogen mustards as potential anticancer drug candidates. |
| AID91909 | The compound was tested for cytotoxicity against human JAR, choriocarcinoma cell line. | 1990 | Journal of medicinal chemistry, Feb, Volume: 33, Issue:2
| Novel prodrugs which are activated to cytotoxic alkylating agents by carboxypeptidase G2. |
| AID1383594 | Antiproliferative activity against human HL60 cells after 72 hrs by MTT assay | 2018 | European journal of medicinal chemistry, Apr-25, Volume: 150 | Novel hybrids of brefeldin A and nitrogen mustards with improved antiproliferative selectivity: Design, synthesis and antitumor biological evaluation. |
| AID1185079 | Antiproliferative activity against human K562 cells assessed as growth inhibition after 72 hrs by MTT assay | 2014 | ACS medicinal chemistry letters, Jul-10, Volume: 5, Issue:7
| Novel hybrids of natural oridonin-bearing nitrogen mustards as potential anticancer drug candidates. |
| AID1393846 | Antiproliferative activity against human LO2 cells after 72 hrs by MTT assay | 2018 | European journal of medicinal chemistry, Feb-25, Volume: 146 | Novel enmein-type diterpenoid hybrids coupled with nitrogen mustards: Synthesis of promising candidates for anticancer therapeutics. |
| AID1185088 | Cytotoxicity against human L02 cells by MTT assay | 2014 | ACS medicinal chemistry letters, Jul-10, Volume: 5, Issue:7
| Novel hybrids of natural oridonin-bearing nitrogen mustards as potential anticancer drug candidates. |
| AID1393847 | Selectivity index, ratio of IC50 for human LO2 cells to IC50 for human Bel7402 cells | 2018 | European journal of medicinal chemistry, Feb-25, Volume: 146 | Novel enmein-type diterpenoid hybrids coupled with nitrogen mustards: Synthesis of promising candidates for anticancer therapeutics. |
| AID101135 | The compound was tested for cytotoxicity against human LS174T,colorectal cell line. | 1990 | Journal of medicinal chemistry, Feb, Volume: 33, Issue:2
| Novel prodrugs which are activated to cytotoxic alkylating agents by carboxypeptidase G2. |
| AID1383598 | Antiproliferative activity against human LO2 cells after 72 hrs by MTT assay | 2018 | European journal of medicinal chemistry, Apr-25, Volume: 150 | Novel hybrids of brefeldin A and nitrogen mustards with improved antiproliferative selectivity: Design, synthesis and antitumor biological evaluation. |
| AID1465330 | Antiproliferative activity against human HepG2 cells treated for 24 hrs measured after 72 hrs by MTT assay | 2017 | Bioorganic & medicinal chemistry letters, 11-15, Volume: 27, Issue:22
| Design and synthesis of novel nitrogen mustard-evodiamine hybrids with selective antiproliferative activity. |
| AID1465332 | Antiproliferative activity against human HL60 cells treated for 24 hrs measured after 72 hrs by MTT assay | 2017 | Bioorganic & medicinal chemistry letters, 11-15, Volume: 27, Issue:22
| Design and synthesis of novel nitrogen mustard-evodiamine hybrids with selective antiproliferative activity. |
| AID1383595 | Antiproliferative activity against human PC3 cells after 72 hrs by MTT assay | 2018 | European journal of medicinal chemistry, Apr-25, Volume: 150 | Novel hybrids of brefeldin A and nitrogen mustards with improved antiproliferative selectivity: Design, synthesis and antitumor biological evaluation. |
| AID1185087 | Anticancer activity against human Bel7402 cells assessed as growth inhibition by MTT assay | 2014 | ACS medicinal chemistry letters, Jul-10, Volume: 5, Issue:7
| Novel hybrids of natural oridonin-bearing nitrogen mustards as potential anticancer drug candidates. |
| AID1060756 | Antitumor activity against mouse B16F10 cells xenografted in C57BL/6 mouse assessed as reduction of tumor size at 100 ug administered as intratumorally for 3 days | 2014 | European journal of medicinal chemistry, Jan, Volume: 71 | Synthesis and analysis of activity of a potential anti-melanoma prodrug with a hydrazine linker. |
| AID1393845 | Antiproliferative activity against human Bel7402/5-FU cells after 72 hrs by MTT assay | 2018 | European journal of medicinal chemistry, Feb-25, Volume: 146 | Novel enmein-type diterpenoid hybrids coupled with nitrogen mustards: Synthesis of promising candidates for anticancer therapeutics. |
| AID1383597 | Antiproliferative activity against human Bel7402/5-FU cells after 72 hrs by MTT assay | 2018 | European journal of medicinal chemistry, Apr-25, Volume: 150 | Novel hybrids of brefeldin A and nitrogen mustards with improved antiproliferative selectivity: Design, synthesis and antitumor biological evaluation. |
| AID1421493 | Antiproliferative activity against human A549 cells after 72 hrs by MTT assay | 2018 | European journal of medicinal chemistry, Oct-05, Volume: 158 | Synthesis of scutellarein derivatives with antiproliferative activity and selectivity through the intrinsic pathway. |
| AID1383596 | Antiproliferative activity against human Bel7402 cells after 72 hrs by MTT assay | 2018 | European journal of medicinal chemistry, Apr-25, Volume: 150 | Novel hybrids of brefeldin A and nitrogen mustards with improved antiproliferative selectivity: Design, synthesis and antitumor biological evaluation. |
| AID1465333 | Antiproliferative activity against human PBMC treated for 24 hrs measured after 72 hrs by MTT assay | 2017 | Bioorganic & medicinal chemistry letters, 11-15, Volume: 27, Issue:22
| Design and synthesis of novel nitrogen mustard-evodiamine hybrids with selective antiproliferative activity. |
| AID1132021 | Toxicity in rat allografted with rat Walker 256 cells | 1978 | Journal of medicinal chemistry, Jan, Volume: 21, Issue:1
| Structure-activity relationships in antitumor aniline mustards. |
| AID1185081 | Antiproliferative activity against human Bel7402 cells assessed as growth inhibition after 72 hrs by MTT assay | 2014 | ACS medicinal chemistry letters, Jul-10, Volume: 5, Issue:7
| Novel hybrids of natural oridonin-bearing nitrogen mustards as potential anticancer drug candidates. |
| AID1393844 | Antiproliferative activity against human Bel7402 cells after 72 hrs by MTT assay | 2018 | European journal of medicinal chemistry, Feb-25, Volume: 146 | Novel enmein-type diterpenoid hybrids coupled with nitrogen mustards: Synthesis of promising candidates for anticancer therapeutics. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |