Compounds > 4-n-bis(2-chloroethyl)aminobenzoylglutamic acid
Page last updated: 2024-12-08

4-n-bis(2-chloroethyl)aminobenzoylglutamic acid

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

4-N-bis(2-chloroethyl)aminobenzoylglutamic acid: structure given in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID151067
CHEMBL ID276682
SCHEMBL ID1064767
MeSH IDM0163590

Synonyms (9)

Synonym
cab-glutamic acid
CHEMBL276682
3086-06-4
l-glutamic acid, n-(4-(bis(2-chloroethyl)amino)benzoyl)-
4-n-bis(2-chloroethyl)aminobenzoylglutamic acid
SCHEMBL1064767
4-(bis(2-chloroethyl)amino) benzoyl-l-glutamic acid
DTXSID20953049
n-{4-[bis(2-chloroethyl)amino]benzoyl}glutamic acid
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (6)

Assay IDTitleYearJournalArticle
AID24282Chemical half-life in percholate at 37 degree was determined1994Journal of medicinal chemistry, Jul-22, Volume: 37, Issue:15
Novel prodrugs of alkylating agents derived from 2-fluoro- and 3-fluorobenzoic acids for antibody-directed enzyme prodrug therapy.
AID48465Michaelis-Menten constant for bacterial Carboxypeptidase1996Journal of medicinal chemistry, Mar-01, Volume: 39, Issue:5
New mustard prodrugs for antibody-directed enzyme prodrug therapy: alternatives to the amide link.
AID48464Catalytic rate constant for bacterial Carboxypeptidase1996Journal of medicinal chemistry, Mar-01, Volume: 39, Issue:5
New mustard prodrugs for antibody-directed enzyme prodrug therapy: alternatives to the amide link.
AID25686Half life period was reported1996Journal of medicinal chemistry, Mar-01, Volume: 39, Issue:5
New mustard prodrugs for antibody-directed enzyme prodrug therapy: alternatives to the amide link.
AID102183Inhibitory concentration was evaluated against colorectal tumar cell line LoVo1996Journal of medicinal chemistry, Mar-01, Volume: 39, Issue:5
New mustard prodrugs for antibody-directed enzyme prodrug therapy: alternatives to the amide link.
AID697312Protein binding in human plasma2012Bioorganic & medicinal chemistry letters, Nov-15, Volume: 22, Issue:22
Development of triazene prodrugs for ADEPT strategy: new insights into drug delivery system based on carboxypeptidase G2 activation.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (5)

TimeframeStudies, This Drug (%)All Drugs %
pre-19901 (20.00)18.7374
1990's3 (60.00)18.2507
2000's0 (0.00)29.6817
2010's1 (20.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.87

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.87 (24.57)
Research Supply Index1.79 (2.92)
Research Growth Index4.66 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.87)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other5 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
4-aminobenzoic acid
4-Aminobenzoic Acid: An aminobenzoic acid isomer that combines with pteridine and GLUTAMIC ACID to form FOLIC ACID. The fact that 4-aminobenzoic acid absorbs light throughout the UVB range has also resulted in its use as an ingredient in SUNSCREENS.. 4-ammoniobenzoate : A zwitterion obtained by transfer of a proton from the carboxy to the amino group of 4-aminobenzoic acid.. 4-aminobenzoic acid : An aminobenzoic acid in which the amino group is para to the carboxy group.		1.9710aminobenzoic acid;
aromatic amino-acid zwitterion		allergen;
Escherichia coli metabolite;
plant metabolite
4-aminobenzoic acid
para-Aminobenzoates: Benzoic acids, salts, or esters that contain an amino group attached to carbon number 4 of the benzene ring structure.. 4-aminobenzoate : An aromatic amino-acid anion that is the conjugate base of 4-aminobenzoic acid.		1.9710aminobenzoate;
aromatic amino-acid anion		Escherichia coli metabolite;
plant metabolite;
Saccharomyces cerevisiae metabolite
4-n-bis(2-chloroethyl)aminobenzoic acid
4-N-bis(2-chloroethyl)aminobenzoic acid: structure given in first source		2.6730
phenacid
phenacid: RN given refers to parent cpd; structure		1.9910
hydroxyaniline mustard
hydroxyaniline mustard: structure; RN given refers to parent cpd		1.9910
phenylenediamine mustard
phenylenediamine mustard: RN given refers to parent cpd		1.9910
4-((2-chloroethyl) (2-mesyloxyethyl)amino)benzoic acid
4-((2-chloroethyl) (2-mesyloxyethyl)amino)benzoic acid: structure given in first source		2.3920
4-((2-chloroethyl)(2-mesyloxyethyl)amino)benzoylglutamic acid
4-((2-chloroethyl)(2-mesyloxyethyl)amino)benzoylglutamic acid: structure in first source		2.3920
ConditionIndicatedRelationship StrengthStudiesTrials
Colorectal Cancer
[description not available]		01.9910
Colorectal Neoplasms
Tumors or cancer of the COLON or the RECTUM or both. Risk factors for colorectal cancer include chronic ULCERATIVE COLITIS; FAMILIAL POLYPOSIS COLI; exposure to ASBESTOS; and irradiation of the CERVIX UTERI.		01.9910
Cancer of Colon
[description not available]		01.9710
Choriocarcinoma
A malignant metastatic form of trophoblastic tumors. Unlike the HYDATIDIFORM MOLE, choriocarcinoma contains no CHORIONIC VILLI but rather sheets of undifferentiated cytotrophoblasts and syncytiotrophoblasts (TROPHOBLASTS). It is characterized by the large amounts of CHORIONIC GONADOTROPIN produced. Tissue origins can be determined by DNA analyses: placental (fetal) origin or non-placental origin (CHORIOCARCINOMA, NON-GESTATIONAL).		02.3820
Colonic Neoplasms
Tumors or cancer of the COLON.		01.9710