Page last updated: 2024-10-06

Kandutsch-Russell Pathway (Cholesterol Biosynthesis)

Proteins (9)

ProteinSynonymsTaxonomy
Delta(24)-sterol reductaseEC 1.3.1.72; 24-dehydrocholesterol reductase; 3-beta-hydroxysterol Delta-24-reductase; Diminuto/dwarf1 homolog; Seladin-1Homo sapiens (human)
Lanosterol 14-alpha demethylaseLDM; EC 1.14.14.154; CYPLI; Cytochrome P450 51A1; Cytochrome P450-14DM; Cytochrome P45014DM; Cytochrome P450LI; Sterol 14-alpha demethylaseHomo sapiens (human)
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomeraseEC 5.3.3.5; Cholestenol Delta-isomerase; Delta(8)-Delta(7) sterol isomerase; D8-D7 sterol isomerase; Emopamil-binding proteinHomo sapiens (human)
7-dehydrocholesterol reductase7-DHC reductase; EC 1.3.1.21; Delta7-sterol reductase; Sterol Delta(7)-reductase; Sterol reductase SR-2Homo sapiens (human)
3-keto-steroid reductase/17-beta-hydroxysteroid dehydrogenase 717-beta-hydroxysteroid dehydrogenase 7; 17-beta-HSD 7; 3-keto-steroid reductase; 1.1.1.270; Dihydrotestosterone oxidoreductase; 1.1.1.210; Estradiol 17-beta-dehydrogenase 7; 1.1.1.62; Short chain dehydrogenase/reductase family 37C member 1Homo sapiens (human)
Lathosterol oxidaseEC 1.14.19.20; C-5 sterol desaturase; Delta(7)-sterol 5-desaturase; Delta(7)-sterol C5(6)-desaturase; Lathosterol 5-desaturase; Sterol-C5-desaturaseHomo sapiens (human)
Delta(14)-sterol reductase LBRDelta-14-SR; EC 1.3.1.70; 3-beta-hydroxysterol Delta (14)-reductase; C-14 sterol reductase; C14SR; Integral nuclear envelope inner membrane protein; LMN2R; Lamin-B receptor; Sterol C14-reductaseHomo sapiens (human)
Sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylatingEC 1.1.1.170; Protein H105e3Homo sapiens (human)
Methylsterol monooxygenase 1EC 1.14.18.9; C-4 methylsterol oxidase; Sterol-C4-methyl oxidaseHomo sapiens (human)

Compounds (19)

CompoundDescription
hydronium ion
ironA metallic element with atomic symbol Fe, atomic number 26, and atomic weight 55.85. It is an essential constituent of HEMOGLOBINS; CYTOCHROMES; and IRON-BINDING PROTEINS. It plays a role in cellular redox reactions and in the transport of OXYGEN.
Carbon DioxideA colorless, odorless gas that can be formed by the body and is necessary for the respiration cycle of plants and animals.
IronA metallic element with atomic symbol Fe, atomic number 26, and atomic weight 55.85. It is an essential constituent of HEMOGLOBINS; CYTOCHROMES; and IRON-BINDING PROTEINS. It plays a role in cellular redox reactions and in the transport of OXYGEN.
CholesterolThe principal sterol of all higher animals, distributed in body tissues, especially the brain and spinal cord, and in animal fats and oils.
flavin mononucleotideA coenzyme for a number of oxidative enzymes including NADH DEHYDROGENASE. It is the principal form in which RIBOFLAVIN is found in cells and tissues.
WaterA clear, odorless, tasteless liquid that is essential for most animal and plant life and is an excellent solvent for many substances. The chemical formula is hydrogen oxide (H2O). (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
OxygenAn element with atomic symbol O, atomic number 8, and atomic weight [15.99903; 15.99977]. It is the most abundant element on earth and essential for respiration.
zymostenolRN given refers to (3beta,5alpha)-isomer; RN for cpd without isomeric designation not available 9/88
32-hydroxy-24,25-dihydrolanosterol
lanosten-3-ol-32-alRN given refers to (3beta)-isomer
4,4-dimethylcholesta-8,14-dien-3-olRN refers to (3beta,5alpha)-isomer; a meiosis-activating sterol
7-dehydrocholesterolRN given refers to (3beta)-isomer; structure; main provitamin in skin that is converted by sunlight to cholecalciferol (vitamin D3)
24,25-dihydrolanosterol
flavin mononucleotide hydroquinonestructure in first source
4-methylcholest-8-en-3-ol, (3beta,4alpha,5alpha)-isomer
lathosterolRN given refers to (3beta,5alpha)-isomer
lanosterolA triterpene that derives from the chair-boat-chair-boat folding of 2,3-oxidosqualene. It is metabolized to CHOLESTEROL and CUCURBITACINS.
creolinfrom refined coal tar oils