Compounds > 2,5-diformylfuran
Page last updated: 2024-12-06

2,5-diformylfuran

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

2,5-Diformylfuran (DFF) is a versatile building block for the synthesis of various functional materials and pharmaceuticals. It is a colorless, crystalline solid that is soluble in most organic solvents. DFF can be synthesized by various methods, including oxidation of furfural with selenium dioxide or nitric acid. DFF is also a key intermediate in the production of furan-based polymers and resins. It exhibits high reactivity due to the presence of two formyl groups, making it a valuable starting material for the synthesis of complex organic molecules. DFF has been investigated as a potential precursor for the synthesis of conductive polymers, fluorescent probes, and pharmaceuticals. The presence of the furan ring and the formyl groups in DFF make it a promising candidate for developing new materials with unique properties. Research on DFF focuses on its synthesis, characterization, and applications in various fields, including organic chemistry, materials science, and medicine. '

2,5-diformylfuran: structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

2,5-diformylfuran : A member of the class of furans carrying two formyl substituents at positions 2 and 5. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Cross-References

ID SourceID
PubMed CID69980
CHEBI ID83385
SCHEMBL ID51391
MeSH IDM0453404

Synonyms (36)

Synonym
furan-2,5-dial
nsc618088
nsc-618088
2,5-furandicarbaldehyde
2,5-furandicarboxaldehyde
2,5-diformylfuran
furan-2,5-dicarbaldehyde
D2408
823-82-5
unii-l4ht8n2z72
l4ht8n2z72 ,
einecs 212-520-7
FT-0600504
AKOS015855726
AM20080614
c6h4o3
5-formylfurfural
2,5-furandicarboxaldehyde [mi]
furan-2,5-dialdehyde
CS-M0775
SCHEMBL51391
furan-2,5-dicarboxaldehyde
CHEBI:83385
DTXSID60231676
C20899
2,5-furandicarbaldehyde #
163857-09-8
2,5-furandicarboxaldehyde, 97%
mfcd00671517
SY047865
DS-15261
YSWG163
BCP14987
Q16736622
2,5-furandicarboxaldehyde, radical ion(1-) (9ci)
SB60899
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Drug Classes (3)

ClassDescription
furansCompounds containing at least one furan ring.
arenecarbaldehydeAny aldehyde in which the carbonyl group is attached to an aromatic moiety.
dialdehydeAny aldehyde with two aldehyde groups.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Pathways (1)

PathwayProteinsCompounds
5-hydroxymethylfurfural degradation821

Research

Studies (12)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's1 (8.33)29.6817
2010's10 (83.33)24.3611
2020's1 (8.33)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 27.82

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index27.82 (24.57)
Research Supply Index2.56 (2.92)
Research Growth Index5.71 (4.65)
Search Engine Demand Index29.35 (26.88)
Search Engine Supply Index2.00 (0.95)

This Compound (27.82)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews1 (8.33%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other11 (91.67%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
nitrates
Nitrates: Inorganic or organic salts and esters of nitric acid. These compounds contain the NO3- radical.		2.0610monovalent inorganic anion;
nitrogen oxoanion;
reactive nitrogen species
2-furoic acid
2-furoic acid: RN given refers to parent cpd. furoic acid : A monocarboxylic acid that consists of a furan ring having a single carboxylic acid group on any ring position and derivatives thereof.. 2-furoic acid : A furoic acid having the carboxylic acid group located at position 2.		2.2110furoic acidbacterial xenobiotic metabolite;
human xenobiotic metabolite;
inhibitor;
plant metabolite;
Saccharomyces cerevisiae metabolite
furaldehyde
Furaldehyde: A heterocyclic compound consisting of a furan where the hydrogen at position 2 is substituted by a formyl group.. furfural : An aldehyde that is furan with the hydrogen at position 2 substituted by a formyl group.		4.92100aldehyde;
furans		Maillard reaction product;
metabolite
durapatite
Durapatite: The mineral component of bones and teeth; it has been used therapeutically as a prosthetic aid and in the prevention and treatment of osteoporosis.. hydroxylapatite : A phosphate mineral with the formula Ca5(PO4)3(OH).		2.110
copper(ii) nitrate
copper(II) nitrate : An inorganic nitrate salt having copper(2+) as the couterion.		2.0610inorganic nitrate salt
molybdenum
Molybdenum: A metallic element with the atomic symbol Mo, atomic number 42, and atomic weight 95.95. It is an essential trace element, being a component of the enzymes xanthine oxidase, aldehyde oxidase, and nitrate reductase.		2.110chromium group element atommicronutrient
ruthenium
Ruthenium: A hard, brittle, grayish-white rare earth metal with an atomic symbol Ru, atomic number 44, and atomic weight 101.07. It is used as a catalyst and hardener for PLATINUM and PALLADIUM.		2.5120iron group element atom;
platinum group metal atom
vanadium
Vanadium: A metallic element with the atomic symbol V, atomic number 23, and atomic weight 50.94. It is used in the manufacture of vanadium steel. Prolonged exposure can lead to chronic intoxication caused by absorption usually via the lungs.		2.0110elemental vanadium;
vanadium group element atom		micronutrient
vanadyl sulfate
[no description available]		2.0610metal sulfate;
vanadium coordination entity
2,5-bis(hydroxymethyl)furan
2,5-dihydroxymethylfuran: structure in first source		2.1510diol;
furans
2,5-furandicarboxylic acid
furan-2,5-dicarboxylic acid : A member of the class of furans carrying two carboxy substituents at positions 2 and 5.		2.2110dicarboxylic acid;
furans		human urinary metabolite
norcantharidin
norcantharidin: structure given in first source; RN given refers to cpds without isomeric designation		2.1510furofuran
5-hydroxymethylfurfural
5-hydroxymethylfurfural: has antisickling activity; HMF is the causative component in honey that affects the presystemic metabolism and pharmacokinetics of GZ in-vivo. 5-hydroxymethylfurfural : A member of the class of furans that is furan which is substituted at positions 2 and 5 by formyl and hydroxymethyl substituents, respectively. Virtually absent from fresh foods, it is naturally generated in sugar-containing foods during storage, and especially by drying or cooking. It is the causative component in honey that affects the presystemic metabolism and pharmacokinetics of GZ in-vivo.		4.8290arenecarbaldehyde;
furans;
primary alcohol		indicator;
Maillard reaction product
raffinose
Raffinose: A trisaccharide occurring in Australian manna (from Eucalyptus spp, Myrtaceae) and in cottonseed meal.. raffinose : A trisaccharide composed of alpha-D-galactopyranose, alpha-D-glucopyranose and beta-D-fructofuranose joined in sequence by 1->6 and 1<->2 glycosidic linkages, respectively.		2.110raffinose family oligosaccharide;
trisaccharide		mouse metabolite;
plant metabolite;
Saccharomyces cerevisiae metabolite
D-fructopyranose
[no description available]		2.0110cyclic hemiketal;
D-fructose;
fructopyranose		sweetening agent
ConditionIndicatedRelationship StrengthStudiesTrials