Compounds > 10-(4'-chlorophenyl)-3-methylflavin
Page last updated: 2024-11-07

10-(4'-chlorophenyl)-3-methylflavin

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

10-(4'-chlorophenyl)-3-methylflavin: structure given in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID128254
CHEMBL ID40675
MeSH IDM0153455

Synonyms (7)

Synonym
10-cpmf
CHEMBL40675 ,
10-(4-chlorophenyl)-3-methylbenzo[g]pteridine-2,4(3h,10h)-dione
65626-87-1
10-(4'-chlorophenyl)-3-methylflavin
benzo(g)pteridine-2,4(3h,10h)-dione, 10-(4-chlorophenyl)-3-methyl-
DTXSID60984190
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Protein Targets (1)

Inhibition Measurements

ProteinTaxonomyMeasurementAverageMin (ref.)Avg (ref.)Max (ref.)Bioassay(s)
Glutathione reductase, mitochondrialHomo sapiens (human)IC50 (µMol)1.00001.00004.55008.1000AID75301
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Biological Processes (4)

Processvia Protein(s)Taxonomy
cellular oxidant detoxificationGlutathione reductase, mitochondrialHomo sapiens (human)
cellular response to oxidative stressGlutathione reductase, mitochondrialHomo sapiens (human)
glutathione metabolic processGlutathione reductase, mitochondrialHomo sapiens (human)
cell redox homeostasisGlutathione reductase, mitochondrialHomo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Molecular Functions (4)

Processvia Protein(s)Taxonomy
electron transfer activityGlutathione reductase, mitochondrialHomo sapiens (human)
NADP bindingGlutathione reductase, mitochondrialHomo sapiens (human)
glutathione-disulfide reductase (NADPH) activityGlutathione reductase, mitochondrialHomo sapiens (human)
flavin adenine dinucleotide bindingGlutathione reductase, mitochondrialHomo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Ceullar Components (5)

Processvia Protein(s)Taxonomy
mitochondrial matrixGlutathione reductase, mitochondrialHomo sapiens (human)
cytosolGlutathione reductase, mitochondrialHomo sapiens (human)
external side of plasma membraneGlutathione reductase, mitochondrialHomo sapiens (human)
extracellular exosomeGlutathione reductase, mitochondrialHomo sapiens (human)
cytosolGlutathione reductase, mitochondrialHomo sapiens (human)
mitochondrionGlutathione reductase, mitochondrialHomo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Bioassays (30)

Assay IDTitleYearJournalArticle
AID222843Antimalarial activity against Plasmodium vinckei V52 on 70 mg/kg intraperitoneal dose1991Journal of medicinal chemistry, Jun, Volume: 34, Issue:6
Flavins as potential antimalarials. 2. 3-Methyl-10-(substituted-phenyl) flavins.
AID75301Inhibitory activity against human glutathione reductase in presence of 100 uM GSSG1996Journal of medicinal chemistry, Mar-29, Volume: 39, Issue:7
Inhibition of human glutathione reductase by 10-arylisoalloxazines: crystalline, kinetic, and electrochemical studies.
AID221891Increase in mean survival days was determined in mice after ip administration of 15 mg/kg1991Journal of medicinal chemistry, Jun, Volume: 34, Issue:6
Flavins as potential antimalarials. 2. 3-Methyl-10-(substituted-phenyl) flavins.
AID110174Oral antimalarial activity against Plasmodium vinckei vinckei in mice (Mus musculus) measured as % cured and increase in MST (days) at 50 mg/kg dose1988Journal of medicinal chemistry, Apr, Volume: 31, Issue:4
Flavins as potential antimalarials. 1. 10-(Halophenyl)-3-methylflavins.
AID117109Oral antimalarial activity against Plasmodium vinckei in mice (Mus musculus) measured as increase in mean survival time at 25 mg/kg dose1988Journal of medicinal chemistry, Apr, Volume: 31, Issue:4
Flavins as potential antimalarials. 1. 10-(Halophenyl)-3-methylflavins.
AID222829Antimalarial activity against Plasmodium vinckei V52 after 20 mg/kg intraperitoneal dose 1991Journal of medicinal chemistry, Jun, Volume: 34, Issue:6
Flavins as potential antimalarials. 2. 3-Methyl-10-(substituted-phenyl) flavins.
AID222826Antimalarial activity was evaluated against Plasmodium vinckei V52 after intraperitoneal administration at dose 15 mg/kg1991Journal of medicinal chemistry, Jun, Volume: 34, Issue:6
Flavins as potential antimalarials. 2. 3-Methyl-10-(substituted-phenyl) flavins.
AID110182Parenteral antimalarial activity against Plasmodium vinckei in mice (Mus musculus) measured as % cured and increase in MST (days) at 20 mg/kg dose1988Journal of medicinal chemistry, Apr, Volume: 31, Issue:4
Flavins as potential antimalarials. 1. 10-(Halophenyl)-3-methylflavins.
AID117113Oral antimalarial activity against Plasmodium vinckei vinckei in mice (Mus musculus) measured as increase in mean survival time at 75 mg/kg dose1988Journal of medicinal chemistry, Apr, Volume: 31, Issue:4
Flavins as potential antimalarials. 1. 10-(Halophenyl)-3-methylflavins.
AID117107Oral antimalarial activity against Plasmodium vinckei in mice (Mus musculus) measured as increase in mean survival time at 150 mg/kg dose1988Journal of medicinal chemistry, Apr, Volume: 31, Issue:4
Flavins as potential antimalarials. 1. 10-(Halophenyl)-3-methylflavins.
AID222831Antimalarial activity was evaluated against Plasmodium vinckei V52 after intraperitoneal administration at dose 25 mg/kg1991Journal of medicinal chemistry, Jun, Volume: 34, Issue:6
Flavins as potential antimalarials. 2. 3-Methyl-10-(substituted-phenyl) flavins.
AID110172Oral antimalarial activity against Plasmodium vinckei in mice (Mus musculus) measured as % cured and increase in MST (days) at 25 mg/kg dose1988Journal of medicinal chemistry, Apr, Volume: 31, Issue:4
Flavins as potential antimalarials. 1. 10-(Halophenyl)-3-methylflavins.
AID117120Parenteral antimalarial activity against Plasmodium vinckei in mice (Mus musculus) measured as increase in mean survival time at 10 mg/kg dose1988Journal of medicinal chemistry, Apr, Volume: 31, Issue:4
Flavins as potential antimalarials. 1. 10-(Halophenyl)-3-methylflavins.
AID110180Parenteral antimalarial activity against Plasmodium vinckei vinckei in mice (Mus musculus) measured as % cured and increase in MST (days) at 15 mg/kg dose1988Journal of medicinal chemistry, Apr, Volume: 31, Issue:4
Flavins as potential antimalarials. 1. 10-(Halophenyl)-3-methylflavins.
AID222825Antimalarial activity against Plasmodium vinckei V52 on 10 mg/kg intraperitoneal dose1991Journal of medicinal chemistry, Jun, Volume: 34, Issue:6
Flavins as potential antimalarials. 2. 3-Methyl-10-(substituted-phenyl) flavins.
AID221902Increase in mean survival days was determined in mice after ip administration of 50 mg/kg; toxic1991Journal of medicinal chemistry, Jun, Volume: 34, Issue:6
Flavins as potential antimalarials. 2. 3-Methyl-10-(substituted-phenyl) flavins.
AID222839Antimalarial activity was evaluated against Plasmodium vinckei vinckei V52 after intraperitoneal administration at dose 50 mg/kg.1991Journal of medicinal chemistry, Jun, Volume: 34, Issue:6
Flavins as potential antimalarials. 2. 3-Methyl-10-(substituted-phenyl) flavins.
AID110178Parenteral antimalarial activity against Plasmodium vinckei in mice (Mus musculus) measured as % cured and increase in MST (days) at 10 mg/kg dose1988Journal of medicinal chemistry, Apr, Volume: 31, Issue:4
Flavins as potential antimalarials. 1. 10-(Halophenyl)-3-methylflavins.
AID117105Oral antimalarial activity against Plasmodium vinckei in mice (Mus musculus) measured as increase in mean survival time at 100 mg/kg dose1988Journal of medicinal chemistry, Apr, Volume: 31, Issue:4
Flavins as potential antimalarials. 1. 10-(Halophenyl)-3-methylflavins.
AID222954Antimalarial activity was evaluated against Plasmodium vinckei vinckeii V52 after intraperitoneal administration at dose 40 mg/kg1991Journal of medicinal chemistry, Jun, Volume: 34, Issue:6
Flavins as potential antimalarials. 2. 3-Methyl-10-(substituted-phenyl) flavins.
AID117111Oral antimalarial activity against Plasmodium vinckei vinckei in mice (Mus musculus) measured as increase in mean survival time at 50 mg/kg dose1988Journal of medicinal chemistry, Apr, Volume: 31, Issue:4
Flavins as potential antimalarials. 1. 10-(Halophenyl)-3-methylflavins.
AID110170Oral antimalarial activity against Plasmodium vinckei vinckei in mice (Mus musculus) measured as % cured and increase in MST (days) at 150 mg/kg dose1988Journal of medicinal chemistry, Apr, Volume: 31, Issue:4
Flavins as potential antimalarials. 1. 10-(Halophenyl)-3-methylflavins.
AID222833Antimalarial activity against Plasmodium vinckei V52 on 30 mg/kg intraperitoneal dose1991Journal of medicinal chemistry, Jun, Volume: 34, Issue:6
Flavins as potential antimalarials. 2. 3-Methyl-10-(substituted-phenyl) flavins.
AID221907Increase in mean survival days was determined in mice after ip administration of 70 mg/kg; toxic1991Journal of medicinal chemistry, Jun, Volume: 34, Issue:6
Flavins as potential antimalarials. 2. 3-Methyl-10-(substituted-phenyl) flavins.
AID117124Parenteral antimalarial activity against Plasmodium vinckei in mice (Mus musculus) measured as increase in mean survival time at 20 mg/kg dose1988Journal of medicinal chemistry, Apr, Volume: 31, Issue:4
Flavins as potential antimalarials. 1. 10-(Halophenyl)-3-methylflavins.
AID110176Oral antimalarial activity against Plasmodium vinckei in mice (Mus musculus) measured as % cured and increase in MST (days) at 75 mg/kg dose1988Journal of medicinal chemistry, Apr, Volume: 31, Issue:4
Flavins as potential antimalarials. 1. 10-(Halophenyl)-3-methylflavins.
AID222973Effective dose required to obtain a parasitaemia of 40% 48 hours after treatment in mice1991Journal of medicinal chemistry, Jun, Volume: 34, Issue:6
Flavins as potential antimalarials. 2. 3-Methyl-10-(substituted-phenyl) flavins.
AID221890Increase in mean survival days was determined in mice after ip administration of 10 mg/kg1991Journal of medicinal chemistry, Jun, Volume: 34, Issue:6
Flavins as potential antimalarials. 2. 3-Methyl-10-(substituted-phenyl) flavins.
AID110168Oral antimalarial activity against Plasmodium vinckei vinckei in mice (Mus musculus) measured as % cured and increase in MST (days) at 100 mg/kg dose1988Journal of medicinal chemistry, Apr, Volume: 31, Issue:4
Flavins as potential antimalarials. 1. 10-(Halophenyl)-3-methylflavins.
AID117122Parenteral antimalarial activity against Plasmodium vinckei in mice (Mus musculus) measured as increase in mean survival time at 15 mg/kg dose1988Journal of medicinal chemistry, Apr, Volume: 31, Issue:4
Flavins as potential antimalarials. 1. 10-(Halophenyl)-3-methylflavins.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (5)

TimeframeStudies, This Drug (%)All Drugs %
pre-19902 (40.00)18.7374
1990's3 (60.00)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.74

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.74 (24.57)
Research Supply Index1.79 (2.92)
Research Growth Index4.54 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.74)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other5 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
riboflavin
vitamin B2 : Any member of a group of vitamers that belong to the chemical structural class called flavins that exhibit biological activity against vitamin B2 deficiency. Symptoms associated with vitamin B2 deficiency include glossitis, seborrhea, angular stomaitis, cheilosis and photophobia. The vitamers include riboflavin and its phosphate derivatives (and includes their salt, ionised and hydrate forms).		2.3720flavin;
vitamin B2		anti-inflammatory agent;
antioxidant;
cofactor;
Escherichia coli metabolite;
food colouring;
fundamental metabolite;
human urinary metabolite;
mouse metabolite;
photosensitizing agent;
plant metabolite
flavin-adenine dinucleotide
Flavin-Adenine Dinucleotide: A condensation product of riboflavin and adenosine diphosphate. The coenzyme of various aerobic dehydrogenases, e.g., D-amino acid oxidase and L-amino acid oxidase. (Lehninger, Principles of Biochemistry, 1982, p972)		1.9710flavin adenine dinucleotide;
vitamin B2		cofactor;
Escherichia coli metabolite;
human metabolite;
mouse metabolite;
prosthetic group
ConditionIndicatedRelationship StrengthStudiesTrials
Infections, Plasmodium
[description not available]		02.3720
Malaria
A protozoan disease caused in humans by four species of the PLASMODIUM genus: PLASMODIUM FALCIPARUM; PLASMODIUM VIVAX; PLASMODIUM OVALE; and PLASMODIUM MALARIAE; and transmitted by the bite of an infected female mosquito of the genus ANOPHELES. Malaria is endemic in parts of Asia, Africa, Central and South America, Oceania, and certain Caribbean islands. It is characterized by extreme exhaustion associated with paroxysms of high FEVER; SWEATING; shaking CHILLS; and ANEMIA. Malaria in ANIMALS is caused by other species of plasmodia.		02.3720