Page last updated: 2024-12-06

1-(4-chlorophenyl)-3,3-dimethyltriazene

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

1-(4-chlorophenyl)-3,3-dimethyltriazene, often shortened to **4-chlorophenyldiazene**, is an **organic compound** that falls under the category of **diazenes**.

Here's why it's important for research:

* **Anti-cancer activity:** This compound has shown potential as an **anti-cancer agent**, particularly against **leukemia**. It acts by interfering with DNA replication and cell division.
* **Precursor for other compounds:** 4-chlorophenyldiazene can be used as a **starting material** to synthesize other compounds with potential biological activity.
* **Model system for studying chemical reactions:** Its reactivity makes it a useful **model system** to study the **chemistry of diazenes**, which are involved in various biological and chemical processes.
* **Probe for biological processes:** Its properties allow it to be used as a **probe** to study the **mechanisms of various biological processes**, such as enzyme activity and drug metabolism.

**However, it's important to note that:**

* **Toxicity:** 4-chlorophenyldiazene exhibits **toxicity**, and its use in humans requires further investigation and safety testing.
* **Limited clinical development:** Despite its promising activity, it has not been fully developed for clinical use, likely due to its toxicity and limitations in its application.

Therefore, while this compound holds promise in research, further investigation is needed to assess its safety and efficacy before it can be used in clinical settings.

Cross-References

ID SourceID
PubMed CID23605
CHEMBL ID49340
MeSH IDM0062001

Synonyms (34)

Synonym
triazene, 3,3-dimethyl-1-(p-chlorophenyl)-
triazene, 1-(p-chlorophenyl)-3,3-dimethyl-
nsc-226083
nsc226083
1-(p-chlorophenyl)-3,3-dimethyltriazine
triazene,3-dimethyl-1-(p-chlorophenyl)-
1-(4-chlorophenyl)-3,3-dimethyltriazene
7203-90-9
wln: gr dnunn1&1
1-(p-chlorophenyl)-3,3-dimethyltriazene
1-(p-chlor-phenyl)-3,3-dimethyl-triazen
nsc115221
nsc-115221
1-p-chlorfenyl-3,3-dimethyltriazen
3,3-dimethyl-1-(4-chlorophenyl)triazene
1-p-chlorfenyl-3,3-dimethyltriazen [czech]
1-(p-chlor-phenyl)-3,3-dimethyl-triazen [german]
ccris 2059
1-(p-chlorophenyl)-3,3-dimethyl-triazene
1-triazene, 1-(4-chlorophenyl)-3,3-dimethyl-
nsc 115221
1-(4-chlorophenyl)-3,3-dimethyltriazine
nsc 226083
brn 1841491
CHEMBL49340
n-[(4-chlorophenyl)diazenyl]-n-methylmethanamine
AKOS006279279
1-p-chlorphenyl-3,3-dimethyltriazen
DTXSID201032014
LF3BW5558X
n-(4-chlorophenyl)diazenyl-n-methylmethanamine
chlorophenyl)-3,3-dimethyltriazene, 1-(4-
1-triazene, 1-(4-chlorophenyl)-3,3-dimethyl-, (e)-
39116-69-3

Research Excerpts

Toxicity

ExcerptReferenceRelevance
" The close correspondence of the two QSAR leaves essentially no means for the synthesis of more potent, less toxic triazenes."( Antitumor 1-(X-aryl)-3,3-dialkyltriazenes. 2. On the role of correlation analysis in decision making in drug modification. Toxicity quantitative structure-activity relationships of 1-(X-phenyl)-3,3-dialkyltriazenes in mice.
Greenberg, N; Hansch, C; Hatheway, GJ; Quinn, FR, 1978
)
0.26
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (10)

Assay IDTitleYearJournalArticle
AID287840Antimalarial activity as parasitaemia after 7 days against Plasmodium berghei NK65 infected JCL-ICR mice (Mus musculus) at 100 mg/kg2007Bioorganic & medicinal chemistry, Apr-15, Volume: 15, Issue:8
Antimalarial activity of 1-aryl-3,3-dialkyltriazenes.
AID19219Partition coefficient (logP)1984Journal of medicinal chemistry, Dec, Volume: 27, Issue:12
1-Aryl-3,3-dimethyltriazenes: potential central nervous system active analogues of 5-(3,3-dimethyl-1-triazeno)imidazole-4-carboxamide (DTIC).
AID132183Maximum increase in life span was measured in B6d2F1 mice after implanting murine leukemia L1210 cells(ic, 10e4 cells) at an intracerebral optimal dose of 80 mg/ (kg day)(qd 1-9)1984Journal of medicinal chemistry, Dec, Volume: 27, Issue:12
1-Aryl-3,3-dimethyltriazenes: potential central nervous system active analogues of 5-(3,3-dimethyl-1-triazeno)imidazole-4-carboxamide (DTIC).
AID132184Maximum increase in life span was measured in B6d2F1 mice after implanting murine leukemia L1210 cells(ip, 10e5 cells) at an intraperitoneal optimal dose of 108 mg/ (kg day)(qd 1-9)1984Journal of medicinal chemistry, Dec, Volume: 27, Issue:12
1-Aryl-3,3-dimethyltriazenes: potential central nervous system active analogues of 5-(3,3-dimethyl-1-triazeno)imidazole-4-carboxamide (DTIC).
AID1148441Toxicity in rat assessed as concentration required for producing T/C of 1401978Journal of medicinal chemistry, Jun, Volume: 21, Issue:6
Antitumor 1-(X-aryl)-3,3-dialkyltriazenes. 2. On the role of correlation analysis in decision making in drug modification. Toxicity quantitative structure-activity relationships of 1-(X-phenyl)-3,3-dialkyltriazenes in mice.
AID1123539Mutagenicity in Salmonella typhimurium strain TA92 assessed as number of bacterial revertants after 2 days by Ames test in presence of rat liver S9 fraction1979Journal of medicinal chemistry, May, Volume: 22, Issue:5
Ames test of 1-(X-phenyl)-3,3-dialkyltriazenes. A quantitative structure-activity study.
AID287841Antimalarial activity as parasitaemia after 14 days against Plasmodium berghei NK65 infected JCL-ICR mice (Mus musculus) at 100 mg/kg2007Bioorganic & medicinal chemistry, Apr-15, Volume: 15, Issue:8
Antimalarial activity of 1-aryl-3,3-dialkyltriazenes.
AID287838Survival rate in Plasmodium berghei NK65 infected JCL-ICR mice (Mus musculus) at 100 mg/kg body weight after 14 days2007Bioorganic & medicinal chemistry, Apr-15, Volume: 15, Issue:8
Antimalarial activity of 1-aryl-3,3-dialkyltriazenes.
AID287839Antimalarial activity as parasitaemia after 3 days against Plasmodium berghei NK65 infected JCL-ICR mice (Mus musculus) at 100 mg/kg2007Bioorganic & medicinal chemistry, Apr-15, Volume: 15, Issue:8
Antimalarial activity of 1-aryl-3,3-dialkyltriazenes.
AID1132824Toxicity in mouse L1210 cells allografted mouse assessed as mortality up to 5 days1978Journal of medicinal chemistry, Jun, Volume: 21, Issue:6
Antitumor 1-(X-aryl)-3,3-dialkyltriazenes. 1. Quantitative structure-activity relationships vs. L1210 leukemia in mice.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (8)

TimeframeStudies, This Drug (%)All Drugs %
pre-19907 (87.50)18.7374
1990's0 (0.00)18.2507
2000's1 (12.50)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 11.94

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index11.94 (24.57)
Research Supply Index2.20 (2.92)
Research Growth Index4.14 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (11.94)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other8 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]