1-phenyl-3,3-dimethyltriazene profile

1-phenyl-3,3-dimethyltriazene (PDT) is an organic compound with the chemical formula C₉H₁₃N₃. It's a colorless liquid that is often used in chemical research for a variety of reasons:

**Properties and Applications:**

* **Diazo Coupling Reagent:** PDT is a key component in diazo coupling reactions. These reactions are used to synthesize a wide range of azo dyes, which are important pigments and colorants in various industries.
* **Nitrosating Agent:** PDT can also act as a nitrosating agent. This property is utilized in organic synthesis to introduce nitro groups onto organic molecules.
* **Photochemistry:** PDT is a photolabile compound, meaning it decomposes upon exposure to light. This property makes it a valuable tool in photochemistry for the study of photochemical reactions and the development of photosensitive materials.

**Why it's important for research:**

* **Synthesis of New Compounds:** PDT plays a vital role in the synthesis of various new compounds, particularly azo dyes and nitro-containing molecules. These compounds have diverse applications in industries like pharmaceuticals, textiles, and pigments.
* **Mechanistic Studies:** Its photolabile nature allows researchers to study photochemical reactions and explore the mechanism of light-induced decomposition.
* **Development of New Materials:** PDT's photochemical properties are being investigated for potential applications in the development of new photosensitive materials like photoresists and photochromic compounds.
* **Drug Discovery:** PDT has also been explored as a potential drug candidate due to its reactivity and potential for selective targeting.

**Safety Considerations:**

It's important to note that PDT is a reactive compound that should be handled with care in a well-ventilated laboratory environment. Proper safety precautions, including wearing protective gear and working under a fume hood, are essential when handling this substance.

In summary, 1-phenyl-3,3-dimethyltriazene (PDT) is an important research chemical with diverse applications in synthesis, photochemistry, and material science. Its unique properties make it a valuable tool for developing new compounds, studying chemical reactions, and exploring potential applications in various fields.

ID Source	ID
PubMed CID	23654
CHEMBL ID	1981220
CHEMBL ID	3188118
SCHEMBL ID	187587
SCHEMBL ID	2109239
MeSH ID	M0053059

Synonym
nsc3094
nsc-3094
3,3-dimethyl-1-phenyltriazene
1-phenyl-3,3-dimethyltriazene
1-triazene,3-dimethyl-1-phenyl-
7227-91-0
wln: 1n1&nunr
pdmt
triazene,3-dimethyl-1-phenyl-
x 119
1-triazene, 3,3-dimethyl-1-phenyl-
triazene, 3,3-dimethyl-1-phenyl-
NCI60_002653
(1e)-3,3-dimethyl-1-phenyltriaz-1-ene
ccris 507
3,3-dimethyl-1-phenyl-1-triazene
ai3-22123
brn 0907506
nsc 3094
einecs 230-627-7
1-fenyl-3,3-dimethyltriazin
n-methyl-n-phenyldiazenylmethanamine
AKOS006282831
cas-7227-91-0
dtxsid5021128 ,
NCGC00255139-01
dtxcid101128
tox21_301876
unii-79r3zf226y
79r3zf226y ,
4-16-00-00903 (beilstein handbook reference)
SCHEMBL187587
SCHEMBL2109239
LLROQAGEAVDYFP-MDZDMXLPSA-N
3,3-dimethyl-1-phenyl-1-triazene #
CHEMBL1981220
dimethyl-1-phenyltriazene, 3,3-
CHEMBL3188118
3,3-dimethyl-1-phenyltriazen
Q27266771

Excerpt	Reference	Relevance
" The close correspondence of the two QSAR leaves essentially no means for the synthesis of more potent, less toxic triazenes."	( Antitumor 1-(X-aryl)-3,3-dialkyltriazenes. 2. On the role of correlation analysis in decision making in drug modification. Toxicity quantitative structure-activity relationships of 1-(X-phenyl)-3,3-dialkyltriazenes in mice. Greenberg, N; Hansch, C; Hatheway, GJ; Quinn, FR, 1978)	0.26
" Thus, to develop the molecular PSs for the improved and safe PDT in clinic, a novel and versatile PS (Mal-Pc) has been designed by di-substituting maleimides to the axial positions of silicon (Ⅳ) phthalocyanine."	( Novel molecular photosensitizer with simultaneously GSH depletion, aggregation inhibition and accelerated elimination for improved and safe photodynamic therapy. Chen, J; Huang, K; Xue, J; Yan, M, 2023)	0.91

Excerpt	Relevance	Reference
" Exposure to single intraperitoneal doses of DMPT on gestation day 20 did not produce a classic dose-response pattern: Minimal effects were observed with 10 mg DMPT/kg (occasional renal mesenchymal tumors and brain neoplasms), marked effects were observed with 30 mg DMPT/kg (lower incidence rate of most of the alterations observed with 1 mg/kg on gestation days 16, 18, and 20), and no effects were observed with 60 mg DMPT/kg."	( Renal transplacental carcinogenicity of 3,3-dimethyl-1-phenyltriazene in rats: relationship of renal mesenchymal tumor to congenital mesoblastic nephroma and intralobar nephrogenic rests. Beckwith, JB; Carlton, WW; Frank, AA; Heidel, JR; Thompson, DJ, 1992)	0.28

Protein	Taxonomy	Measurement	Average (µ)	Min (ref.)	Avg (ref.)	Max (ref.)	Bioassay(s)
RAR-related orphan receptor gamma	Mus musculus (house mouse)	Potency	70.6217	0.0060	38.0041	19,952.5996	AID1159521; AID1159523
aryl hydrocarbon receptor	Homo sapiens (human)	Potency	76.9588	0.0007	23.0674	1,258.9301	AID743085
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Assay ID	Title	Year	Journal	Article
AID1148441	Toxicity in rat assessed as concentration required for producing T/C of 140	1978	Journal of medicinal chemistry, Jun, Volume: 21, Issue:6	Antitumor 1-(X-aryl)-3,3-dialkyltriazenes. 2. On the role of correlation analysis in decision making in drug modification. Toxicity quantitative structure-activity relationships of 1-(X-phenyl)-3,3-dialkyltriazenes in mice.
AID1132827	Aqueous phase distribution coefficient, log P of the compound in phosphate buffer at pH 7.4	1978	Journal of medicinal chemistry, Jun, Volume: 21, Issue:6	Antitumor 1-(X-aryl)-3,3-dialkyltriazenes. 1. Quantitative structure-activity relationships vs. L1210 leukemia in mice.
AID1148443	Toxicity in CDF1 mouse assessed as concentration required for producing T/C of 140	1978	Journal of medicinal chemistry, Jun, Volume: 21, Issue:6	Antitumor 1-(X-aryl)-3,3-dialkyltriazenes. 2. On the role of correlation analysis in decision making in drug modification. Toxicity quantitative structure-activity relationships of 1-(X-phenyl)-3,3-dialkyltriazenes in mice.
AID1132823	Distribution coefficient, log P of the compound	1978	Journal of medicinal chemistry, Jun, Volume: 21, Issue:6	Antitumor 1-(X-aryl)-3,3-dialkyltriazenes. 1. Quantitative structure-activity relationships vs. L1210 leukemia in mice.
AID1132822	Antitumor activity against mouse L1210 cells allografted in mouse assessed as increase of host lifespan	1978	Journal of medicinal chemistry, Jun, Volume: 21, Issue:6	Antitumor 1-(X-aryl)-3,3-dialkyltriazenes. 1. Quantitative structure-activity relationships vs. L1210 leukemia in mice.
AID1123539	Mutagenicity in Salmonella typhimurium strain TA92 assessed as number of bacterial revertants after 2 days by Ames test in presence of rat liver S9 fraction	1979	Journal of medicinal chemistry, May, Volume: 22, Issue:5	Ames test of 1-(X-phenyl)-3,3-dialkyltriazenes. A quantitative structure-activity study.
AID1148444	Lipophilicity, log P of the compound	1978	Journal of medicinal chemistry, Jun, Volume: 21, Issue:6	Antitumor 1-(X-aryl)-3,3-dialkyltriazenes. 2. On the role of correlation analysis in decision making in drug modification. Toxicity quantitative structure-activity relationships of 1-(X-phenyl)-3,3-dialkyltriazenes in mice.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	14 (29.17)	18.7374
1990's	7 (14.58)	18.2507
2000's	7 (14.58)	29.6817
2010's	3 (6.25)	24.3611
2020's	17 (35.42)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	1 (2.08%)	6.00%
Case Studies	1 (2.08%)	4.05%
Observational	0 (0.00%)	0.25%
Other	46 (95.83%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
aminolevulinic acid Aminolevulinic Acid: A compound produced from succinyl-CoA and GLYCINE as an intermediate in heme synthesis. It is used as a PHOTOCHEMOTHERAPY for actinic KERATOSIS.. 5-aminolevulinic acid : The simplest delta-amino acid in which the hydrogens at the gamma position are replaced by an oxo group. It is metabolised to protoporphyrin IX, a photoactive compound which accumulates in the skin. Used (in the form of the hydrochloride salt)in combination with blue light illumination for the treatment of minimally to moderately thick actinic keratosis of the face or scalp.	2.69	2	4-oxo monocarboxylic acid; amino acid zwitterion; delta-amino acid	antineoplastic agent; dermatologic drug; Escherichia coli metabolite; human metabolite; mouse metabolite; photosensitizing agent; plant metabolite; prodrug; Saccharomyces cerevisiae metabolite
carbon monoxide Carbon Monoxide: Carbon monoxide (CO). A poisonous colorless, odorless, tasteless gas. It combines with hemoglobin to form carboxyhemoglobin, which has no oxygen carrying capacity. The resultant oxygen deprivation causes headache, dizziness, decreased pulse and respiratory rates, unconsciousness, and death. (From Merck Index, 11th ed). carbon monoxide : A one-carbon compound in which the carbon is joined only to a single oxygen. It is a colourless, odourless, tasteless, toxic gas.	2.03	1	carbon oxide; gas molecular entity; one-carbon compound	biomarker; EC 1.9.3.1 (cytochrome c oxidase) inhibitor; human metabolite; ligand; metabolite; mitochondrial respiratory-chain inhibitor; mouse metabolite; neurotoxin; neurotransmitter; P450 inhibitor; probe; signalling molecule; vasodilator agent
hydrogen Hydrogen: The first chemical element in the periodic table with atomic symbol H, and atomic number 1. Protium (atomic weight 1) is by far the most common hydrogen isotope. Hydrogen also exists as the stable isotope DEUTERIUM (atomic weight 2) and the radioactive isotope TRITIUM (atomic weight 3). Hydrogen forms into a diatomic molecule at room temperature and appears as a highly flammable colorless and odorless gas.. dihydrogen : An elemental molecule consisting of two hydrogens joined by a single bond.	2.03	1	elemental hydrogen; elemental molecule; gas molecular entity	antioxidant; electron donor; food packaging gas; fuel; human metabolite
toluene methylbenzene : Any alkylbenzene that is benzene substituted with one or more methyl groups.	2.03	1	methylbenzene; toluenes; volatile organic compound	cholinergic antagonist; fuel additive; neurotoxin; non-polar solvent
benzo(a)pyrene Benzo(a)pyrene: A potent mutagen and carcinogen. It is a public health concern because of its possible effects on industrial workers, as an environmental pollutant, an as a component of tobacco smoke.. benzo[a]pyrene : An ortho- and peri-fused polycyclic arene consisting of five fused benzene rings.	1.96	1	ortho- and peri-fused polycyclic arene	carcinogenic agent; mouse metabolite
clioquinol Clioquinol: A potentially neurotoxic 8-hydroxyquinoline derivative long used as a topical anti-infective, intestinal antiamebic, and vaginal trichomonacide. The oral preparation has been shown to cause subacute myelo-optic neuropathy and has been banned worldwide.. 5-chloro-7-iodoquinolin-8-ol : A monohydroxyquinoline that is quinolin-8-ol in which the hydrogens at positions 5 and 7 are replaced by chlorine and iodine, respectively. It has antibacterial and atifungal properties, and is used in creams for the treatment of skin infections. It has also been investigated as a chelator of copper and zinc ions for the possible treatment of Alzheimer's disease.	2.04	1	monohydroxyquinoline; organochlorine compound; organoiodine compound	antibacterial agent; antifungal agent; antimicrobial agent; antineoplastic agent; antiprotozoal drug; chelator; copper chelator
fluphenazine [no description available]	2.03	1	N-alkylpiperazine; organofluorine compound; phenothiazines	anticoronaviral agent; dopaminergic antagonist; phenothiazine antipsychotic drug
ha14-1 ethyl 2-amino-6-bromo-4-(1-cyano-2-ethoxy-2-oxoethyl)-4H-chromene-3-carboxylate: a BH3 mimetic; synergistic induction of apoptosis by simultaneous disruption of the Bcl-2 and MEK/MAPK pathways in acute myelogenous leukemia	2.02	1	1-benzopyran
methadone Methadone: A synthetic opioid that is used as the hydrochloride. It is an opioid analgesic that is primarily a mu-opioid agonist. It has actions and uses similar to those of MORPHINE. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1082-3). methadone : A racemate comprising equimolar amounts of dextromethadone and levomethadone. It is a opioid analgesic which is used as a painkiller and as a substitute for heroin in the treatment of heroin addiction.. 6-(dimethylamino)-4,4-diphenylheptan-3-one : A ketone that is heptan-3-one substituted by a dimethylamino group at position 6 and two phenyl groups at position 4.	2.25	1	benzenes; diarylmethane; ketone; tertiary amino compound
n,n,n',n'-tetrakis(2-pyridylmethyl)ethylenediamine N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine: a zinc ion chelating agent; structure given in first source. N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine : An N-substituted diamine that is ethylenediamine in which the four amino hydrogens are replaced by 2-pyridylmethyl groups.	2.04	1	N-substituted diamine; pyridines; tertiary amino compound	apoptosis inducer; chelator; copper chelator
sucrose Saccharum: A plant genus of the family POACEAE widely cultivated in the tropics for the sweet cane that is processed into sugar.	1.95	1	glycosyl glycoside	algal metabolite; Escherichia coli metabolite; human metabolite; mouse metabolite; osmolyte; Saccharomyces cerevisiae metabolite; sweetening agent
methylene blue Methylene Blue: A compound consisting of dark green crystals or crystalline powder, having a bronze-like luster. Solutions in water or alcohol have a deep blue color. Methylene blue is used as a bacteriologic stain and as an indicator. It inhibits GUANYLATE CYCLASE, and has been used to treat cyanide poisoning and to lower levels of METHEMOGLOBIN.. methylene blue : An organic chloride salt having 3,7-bis(dimethylamino)phenothiazin-5-ium as the counterion. A commonly used dye that also exhibits antioxidant, antimalarial, antidepressant and cardioprotective properties.	2.25	1	organic chloride salt	acid-base indicator; antidepressant; antimalarial; antimicrobial agent; antioxidant; cardioprotective agent; EC 1.4.3.4 (monoamine oxidase) inhibitor; EC 3.1.1.8 (cholinesterase) inhibitor; EC 4.6.1.2 (guanylate cyclase) inhibitor; fluorochrome; histological dye; neuroprotective agent; physical tracer
methionine Methionine: A sulfur-containing essential L-amino acid that is important in many body functions.. methionine : A sulfur-containing amino acid that is butyric acid bearing an amino substituent at position 2 and a methylthio substituent at position 4.	1.96	1	aspartate family amino acid; L-alpha-amino acid; methionine zwitterion; methionine; proteinogenic amino acid	antidote to paracetamol poisoning; human metabolite; micronutrient; mouse metabolite; nutraceutical
triaziquone Triaziquone: Alkylating antineoplastic agent used mainly for ovarian tumors. It is toxic to skin, gastrointestinal tract, bone marrow and kidneys.. triaziquone : A member of the class of 1,4-benzoquinones that is 1,4-benzoquinone in which three of the ring hydrogens are replaced by aziridin-1-yl groups.	1.95	1	1,4-benzoquinones; aziridines	alkylating agent; antineoplastic agent
propane Propane: A three carbon alkane with the formula H3CCH2CH3.	2.03	1	alkane; gas molecular entity	food propellant
quinoxalines quinoxaline : A naphthyridine in which the nitrogens are at positions 1 and 4.	2.17	1	mancude organic heterobicyclic parent; naphthyridine; ortho-fused heteroarene
tolonium chloride Tolonium Chloride: A phenothiazine that has been used as a hemostatic, a biological stain, and a dye for wool and silk. Tolonium chloride has also been used as a diagnostic aid for oral and gastric neoplasms and in the identification of the parathyroid gland in thyroid surgery.. tolonium chloride : An organic chloride salt having 3-amino-7-(dimethylamino)-2-methylphenothiazin-5-ium (tolonium) as the counterion. It is a blue nuclear counterstain that can be used to demonstrate Nissl substance and is also useful for staining mast cell granules, both in metachromatic and orthochromatic techniques.	3.41	1
4-methylquinoline 4-methylquinoline: structure given in first source; RN given refers to parent cpd. 4-methylquinoline : A methylquinoline carrying a methyl substituent at position 4.	2.17	1	methylquinoline	mutagen
dithiol dithiol: structure	2.03	1
1-(4-chlorophenyl)-3,3-dimethyltriazene [no description available]	2.87	4
1-(4-carboxyphenyl)-3,3-dimethyltriazene 1-(4-carboxyphenyl)-3,3-dimethyltriazene: RN given refers to parent cpd	1.95	1
argon Argon: A noble gas with the atomic symbol Ar, atomic number 18, and atomic weight 39.948. It is used in fluorescent tubes and wherever an inert atmosphere is desired and nitrogen cannot be used.	1.99	1	monoatomic argon; noble gas atom; p-block element atom	food packaging gas; neuroprotective agent
gold Gold: A yellow metallic element with the atomic symbol Au, atomic number 79, and atomic weight 197. It is used in jewelry, goldplating of other metals, as currency, and in dental restoration. Many of its clinical applications, such as ANTIRHEUMATIC AGENTS, are in the form of its salts.	2.82	2	copper group element atom; elemental gold
fluorides [no description available]	1.95	1	halide anion; monoatomic fluorine
paclitaxel Taxus: Genus of coniferous yew trees or shrubs, several species of which have medicinal uses. Notable is the Pacific yew, Taxus brevifolia, which is used to make the anti-neoplastic drug taxol (PACLITAXEL).	2.05	1	taxane diterpenoid; tetracyclic diterpenoid	antineoplastic agent; human metabolite; metabolite; microtubule-stabilising agent
temoporfin temoporfin: used as PHOTOCHEMOTHERAPY	2.42	2
o-(6)-methylguanine O-(6)-methylguanine: structure. 6-O-methylguanine : A methylguanine in which the methyl group is positioned on the oxygen at position 6. Formed in DNA by alkylation of the oxygen atom of guanine, most often by N-nitroso compounds and sometimes due to methylation by other compounds such as endogenous S-adenosylmethionine, it base-pairs to thymine rather than cytidine, causing a G:C to A:T transition in DNA.. methylguanine : A 2-aminopurine that is guanine bearing a single methyl substituent.	1.98	1	methylguanine	mutagen
1,7-phenanthroline [no description available]	2.17	1	phenanthroline
o(6)-methyl-2'-deoxyguanosine O(6)-methyl-2'-deoxyguanosine: RN given refers to (beta)-isomer. O(6)-methyl-2'-deoxyguanosine : A purine 2'-deoxyribonucleoside having O(6)-methylguanine as the nucleobase.	1.98	1	purine 2'-deoxyribonucleoside
ceric oxide ceric oxide: RN given refers to cpd with MF CeO2. ceric oxide : A metal oxide with formula CeO2. It is used for polishing glass, in coatings for infra-red filters to prevent reflection, and as an oxidant and catalyst in organic synthesis.	2.41	1	cerium molecular entity; metal oxide
1-(4-tolyl)-3,3-dimethyltriazene [no description available]	2.65	3
1-(4-nitrophenyl)-3,3-dimethyltriazene [no description available]	2.65	3
3-methyl-1-phenyltriazene [no description available]	2.36	2
1-(4-carboxamidophenyl)-3,3-dimethyltriazene [no description available]	2.65	3
cobalt Cobalt: A trace element that is a component of vitamin B12. It has the atomic symbol Co, atomic number 27, and atomic weight 58.93. It is used in nuclear weapons, alloys, and pigments. Deficiency in animals leads to anemia; its excess in humans can lead to erythrocytosis.. cobalt(1+) : A monovalent inorganic cation obtained from cobalt.. cobalt atom : A cobalt group element atom that has atomic number 27.	2.17	1	cobalt group element atom; metal allergen	micronutrient
2-(1-hexyloxyethyl)-2-devinyl pyropheophorbide-a 2-(1-hexyloxyethyl)-2-devinyl pyropheophorbide-a: a photodynamic sensitizer; structure given in first source	2.41	1
aflatoxin b1 Aflatoxin B1: A potent hepatotoxic and hepatocarcinogenic mycotoxin produced by the Aspergillus flavus group of fungi. It is also mutagenic, teratogenic, and causes immunosuppression in animals. It is found as a contaminant in peanuts, cottonseed meal, corn, and other grains. The mycotoxin requires epoxidation to aflatoxin B1 2,3-oxide for activation. Microsomal monooxygenases biotransform the toxin to the less toxic metabolites aflatoxin M1 and Q1.. aflatoxin B1 : An aflatoxin having a tetrahydrocyclopenta[c]furo[3',2':4,5]furo[2,3-h]chromene skeleton with oxygen functionality at positions 1, 4 and 11.	1.95	1	aflatoxin; aromatic ether; aromatic ketone	carcinogenic agent; human metabolite
betadex beta-Cyclodextrins: Cyclic GLUCANS consisting of seven (7) glucopyranose units linked by 1,4-glycosidic bonds.	2.41	1	cyclodextrin
nadp [no description available]	1.96	1
naphthoquinones Naphthoquinones: Naphthalene rings which contain two ketone moieties in any position. They can be substituted in any position except at the ketone groups.	1.95	1
dinoprostone prostaglandin E2 : Prostaglandin F2alpha in which the hydroxy group at position 9 has been oxidised to the corresponding ketone. Prostaglandin E2 is the most common and most biologically potent of mammalian prostaglandins.	2.41	1	prostaglandins E	human metabolite; mouse metabolite; oxytocic
boron Boron: A trace element with the atomic symbol B, atomic number 5, and atomic weight [10.806; 10.821]. Boron-10, an isotope of boron, is used as a neutron absorber in BORON NEUTRON CAPTURE THERAPY.	2.05	1	boron group element atom; metalloid atom; nonmetal atom	micronutrient
phytochlorin phytochlorin: RN given refers to (2S-trans)-isomer; structure given in the first source	2.05	1
talaporfin Talaporfin: effective tumor localizer that brings about the selective degradation of tumor tissue following light exposure; structure given in first source	2.02	1
sb 3ct compound SB 3CT compound: a matrix metalloproteinase-2 inhibitor; structure in first source	2.41	1	aromatic ether
chlorophyll a Chlorophyll: Porphyrin derivatives containing magnesium that act to convert light energy in photosynthetic organisms.. chlorophyll : A family of magnesium porphyrins, defined by the presence of a fifth ring beyond the four pyrrole-like rings. The rings can have various side chains which usually include a long phytol chain.	2.41	1	chlorophyll; methyl ester	cofactor
deoxyguanosine [no description available]	1.98	1	purine 2'-deoxyribonucleoside; purines 2'-deoxy-D-ribonucleoside	Escherichia coli metabolite; human metabolite; mouse metabolite; Saccharomyces cerevisiae metabolite
guanine [no description available]	1.98	1	2-aminopurines; oxopurine; purine nucleobase	algal metabolite; Escherichia coli metabolite; human metabolite; mouse metabolite; Saccharomyces cerevisiae metabolite
dacarbazine (E)-dacarbazine : A dacarbazine in which the N=N double bond adopts a trans-configuration.	2.65	3	dacarbazine
aluminum tetrasulfophthalocyanine [no description available]	2.03	1

Condition	Relationship Strength	Studies
Leukemia L 1210 [description not available]	2.65	3
Benign Neoplasms [description not available]	3.51	5
Neoplasms New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.	3.51	5
Bladder Cancer [description not available]	2.41	1
Urinary Bladder Neoplasms Tumors or cancer of the URINARY BLADDER.	2.41	1
Malignant Melanoma [description not available]	2.44	2
Melanoma A malignant neoplasm derived from cells that are capable of forming melanin, which may occur in the skin of any part of the body, in the eye, or, rarely, in the mucous membranes of the genitalia, anus, oral cavity, or other sites. It occurs mostly in adults and may originate de novo or from a pigmented nevus or malignant lentigo. Melanomas frequently metastasize widely, and the regional lymph nodes, liver, lungs, and brain are likely to be involved. The incidence of malignant skin melanomas is rising rapidly in all parts of the world. (Stedman, 25th ed; from Rook et al., Textbook of Dermatology, 4th ed, p2445)	2.44	2
Neoplasms, Pleural [description not available]	2.41	1
Critical Illness A disease or state in which death is possible or imminent.	2.25	1
Tracheal Stenosis A pathological narrowing of the TRACHEA.	2.25	1
Infections, Coronavirus [description not available]	2.25	1
Respiratory Syndrome, Acute, Severe [description not available]	2.25	1
2019 Novel Coronavirus Disease [description not available]	2.25	1
Pneumonia, Viral Inflammation of the lung parenchyma that is caused by a viral infection.	2.25	1
Coronavirus Infections Virus diseases caused by the CORONAVIRUS genus. Some specifics include transmissible enteritis of turkeys (ENTERITIS, TRANSMISSIBLE, OF TURKEYS); FELINE INFECTIOUS PERITONITIS; and transmissible gastroenteritis of swine (GASTROENTERITIS, TRANSMISSIBLE, OF SWINE).	2.25	1
Severe Acute Respiratory Syndrome A viral disorder characterized by high FEVER, dry COUGH, shortness of breath (DYSPNEA) or breathing difficulties, and atypical PNEUMONIA. A virus in the genus CORONAVIRUS is the suspected agent.	2.25	1
Acne [description not available]	2.31	1
Acne Vulgaris A chronic disorder of the pilosebaceous apparatus associated with an increase in sebum secretion. It is characterized by open comedones (blackheads), closed comedones (whiteheads), and pustular nodules. The cause is unknown, but heredity and age are predisposing factors.	2.31	1
Dermatophytoses [description not available]	2.31	1
Tinea Fungal infection of keratinized tissues such as hair, skin and nails. The main causative fungi include MICROSPORUM; TRICHOPHYTON; and EPIDERMOPHYTON.	2.31	1
Wet Macular Degeneration A form of RETINAL DEGENERATION in which abnormal CHOROIDAL NEOVASCULARIZATION occurs under the RETINA and MACULA LUTEA, causing bleeding and leaking of fluid. This leads to bulging and or lifting of the macula and the distortion or destruction of central vision.	2.15	1
Cancer of Ovary [description not available]	2.04	1
Ovarian Neoplasms Tumors or cancer of the OVARY. These neoplasms can be benign or malignant. They are classified according to the tissue of origin, such as the surface EPITHELIUM, the stromal endocrine cells, and the totipotent GERM CELLS.	2.04	1
Adenocarcinoma, Basal Cell [description not available]	2.05	1
Cancer of Colon [description not available]	2.05	1
Adenocarcinoma A malignant epithelial tumor with a glandular organization.	2.05	1
Colonic Neoplasms Tumors or cancer of the COLON.	2.05	1
Age-Related Macular Degeneration [description not available]	2.07	1
Choroid Diseases Disorders of the choroid including hereditary choroidal diseases, neoplasms, and other abnormalities of the vascular layer of the uvea.	2.07	1
Macular Degeneration Degenerative changes in the RETINA usually of older adults which results in a loss of vision in the center of the visual field (the MACULA LUTEA) because of damage to the retina. It occurs in dry and wet forms.	2.07	1
Liver Dysfunction [description not available]	1.93	1
Abdominal Injuries General or unspecified injuries involving organs in the abdominal cavity.	1.93	1
Liver Diseases Pathological processes of the LIVER.	1.93	1
Hepatocellular Carcinoma [description not available]	2.02	1
Cancer of Liver [description not available]	2.02	1
Carcinoma, Hepatocellular A primary malignant neoplasm of epithelial liver cells. It ranges from a well-differentiated tumor with EPITHELIAL CELLS indistinguishable from normal HEPATOCYTES to a poorly differentiated neoplasm. The cells may be uniform or markedly pleomorphic, or form GIANT CELLS. Several classification schemes have been suggested.	2.02	1
Liver Neoplasms Tumors or cancer of the LIVER.	2.02	1
Experimental Neoplasms [description not available]	2.37	2
Delayed Effects, Prenatal Exposure [description not available]	1.96	1
Pregnancy The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.	3.22	6
Abnormalities, Drug-Induced Congenital abnormalities caused by medicinal substances or drugs of abuse given to or taken by the mother, or to which she is inadvertently exposed during the manufacture of such substances. The concept excludes abnormalities resulting from exposure to non-medicinal chemicals in the environment.	2.67	3
Carcinoma, Epidermoid [description not available]	1.99	1
Cancer of Esophagus [description not available]	1.99	1
Carcinoma, Squamous Cell A carcinoma derived from stratified SQUAMOUS EPITHELIAL CELLS. It may also occur in sites where glandular or columnar epithelium is normally present. (From Stedman, 25th ed)	1.99	1
Esophageal Neoplasms Tumors or cancer of the ESOPHAGUS.	1.99	1
Neoplasms, Bronchial [description not available]	1.99	1
Bronchial Neoplasms Tumors or cancer of the BRONCHI.	1.99	1
Congenital Micrognathia [description not available]	2.38	2
Body Weight The mass or quantity of heaviness of an individual. It is expressed by units of pounds or kilograms.	1.98	1
Benign Neoplasms, Brain [description not available]	1.98	1
Cancer of Kidney [description not available]	1.98	1
Bilateral Wilms Tumor [description not available]	1.98	1
Cancer of Testis [description not available]	1.98	1
Fibro-Odontoma [description not available]	1.98	1
Brain Neoplasms Neoplasms of the intracranial components of the central nervous system, including the cerebral hemispheres, basal ganglia, hypothalamus, thalamus, brain stem, and cerebellum. Brain neoplasms are subdivided into primary (originating from brain tissue) and secondary (i.e., metastatic) forms. Primary neoplasms are subdivided into benign and malignant forms. In general, brain tumors may also be classified by age of onset, histologic type, or presenting location in the brain.	1.98	1
Kidney Neoplasms Tumors or cancers of the KIDNEY.	1.98	1
Wilms Tumor A malignant kidney tumor, caused by the uncontrolled multiplication of renal stem (blastemal), stromal (STROMAL CELLS), and epithelial (EPITHELIAL CELLS) elements. However, not all three are present in every case. Several genes or chromosomal areas have been associated with Wilms tumor which is usually found in childhood as a firm lump in a child's side or ABDOMEN.	1.98	1
Testicular Neoplasms Tumors or cancer of the TESTIS. Germ cell tumors (GERMINOMA) of the testis constitute 95% of all testicular neoplasms.	1.98	1
Abnormalities, Autosome [description not available]	1.97	1

1-phenyl-3,3-dimethyltriazene

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Research Demand Index: 11.05

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