Page last updated: 2024-12-07

1-(4-tolyl)-3,3-dimethyltriazene

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

1-(4-tolyl)-3,3-dimethyltriazene, also known as **4-tolyldiazene**, is a **diazo compound** that is important in research for a few reasons:

**1. Synthesis and Reactivity:**

* **Versatile Precursor:** It acts as a versatile precursor for various synthetic reactions, particularly in the generation of diazoalkanes and diazonium salts. These intermediates are crucial for various organic transformations.
* **Click Chemistry:** The triazene moiety can be involved in click chemistry reactions, which are highly efficient and selective reactions used in drug discovery, materials science, and bioconjugation.

**2. Biological Activity:**

* **Antimicrobial and Anticancer Activity:** Some studies suggest that 1-(4-tolyl)-3,3-dimethyltriazene derivatives exhibit antimicrobial and anticancer activities. This potential makes them interesting candidates for drug development research.
* **DNA Binding:** Its structure allows it to bind to DNA, which can have implications for its biological activity.

**3. Theoretical and Computational Studies:**

* **Theoretical Model:** The compound is a popular model system for theoretical and computational studies of diazo compounds, particularly in exploring their electronic structure and reactivity.

**4. Other Applications:**

* **Dye Synthesis:** It can be used in the synthesis of various dyes, including azo dyes.
* **Polymer Chemistry:** Its ability to undergo polymerization reactions makes it relevant in the development of new polymers.

**It's important to note that while 1-(4-tolyl)-3,3-dimethyltriazene is a promising compound for various research fields, it is crucial to consider its potential toxicity and hazards.** Safety precautions should always be taken when handling this compound and any related experiments.

In summary, 1-(4-tolyl)-3,3-dimethyltriazene is a versatile diazo compound with potential applications in organic synthesis, click chemistry, drug discovery, and materials science. Its importance in research stems from its unique properties, reactivity, and potential for further development in various fields.

Cross-References

ID SourceID
PubMed CID81618
CHEMBL ID3230455
SCHEMBL ID7862256
SCHEMBL ID17709235
MeSH IDM0103032

Synonyms (37)

Synonym
1-p-tolyl-3,3-dimethyltriazene
1-triazene,3-dimethyl-1-(4-methylphenyl)-
3,3-dimethyl-1-p-tolyltriazene
triazene,3-dimethyl-1-p-tolyl-
nsc-48821
nsc48821
1-(4-methylphenyl)-3,3-dimethyltriazene
triazene,3-dimethyl-1-(p-methylphenyl)-
u 14439
1-p-methylfenyl-3,3-dimethyltriazen
wln: 1n1&nunr d1
7203-89-6
IDI1_012232
SR-01000641728-1
3,3-dimethyl-1-p-tolyltriazene, 97%
triazene, 3,3-dimethyl-1-p-tolyl-
nsc 48821
triazene, 3,3-dimethyl-1-(p-methylphenyl)-
3,3-dimethyl-1-(p-methylphenyl)triazene
1-p-methylfenyl-3,3-dimethyltriazen [czech]
ccris 1994
1-triazene, 3,3-dimethyl-1-(4-methylphenyl)-
1-(4-methylphenyl)-3,3-dimethyltriazine
ai3-50824
1-(4-tolyl)-3,3-dimethyltriazene
MAYBRIDGE3_000845
HMS1433G09
3,3-dimethyl-1-(4-methylphenyl)triaz-1-ene
n-methyl-n-[(4-methylphenyl)diazenyl]methanamine
CCG-52494
CHEMBL3230455
SCHEMBL7862256
SCHEMBL17709235
3,3-dimethyl-1-p-tolyl-triazen
(e)-3,3-dimethyl-1-p-tolyltriaz-1-ene
2E2JG4C5BD
DTXSID801032012

Research Excerpts

Toxicity

ExcerptReferenceRelevance
" The close correspondence of the two QSAR leaves essentially no means for the synthesis of more potent, less toxic triazenes."( Antitumor 1-(X-aryl)-3,3-dialkyltriazenes. 2. On the role of correlation analysis in decision making in drug modification. Toxicity quantitative structure-activity relationships of 1-(X-phenyl)-3,3-dialkyltriazenes in mice.
Greenberg, N; Hansch, C; Hatheway, GJ; Quinn, FR, 1978
)
0.26
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (7)

Assay IDTitleYearJournalArticle
AID1123539Mutagenicity in Salmonella typhimurium strain TA92 assessed as number of bacterial revertants after 2 days by Ames test in presence of rat liver S9 fraction1979Journal of medicinal chemistry, May, Volume: 22, Issue:5
Ames test of 1-(X-phenyl)-3,3-dialkyltriazenes. A quantitative structure-activity study.
AID1148443Toxicity in CDF1 mouse assessed as concentration required for producing T/C of 1401978Journal of medicinal chemistry, Jun, Volume: 21, Issue:6
Antitumor 1-(X-aryl)-3,3-dialkyltriazenes. 2. On the role of correlation analysis in decision making in drug modification. Toxicity quantitative structure-activity relationships of 1-(X-phenyl)-3,3-dialkyltriazenes in mice.
AID1148441Toxicity in rat assessed as concentration required for producing T/C of 1401978Journal of medicinal chemistry, Jun, Volume: 21, Issue:6
Antitumor 1-(X-aryl)-3,3-dialkyltriazenes. 2. On the role of correlation analysis in decision making in drug modification. Toxicity quantitative structure-activity relationships of 1-(X-phenyl)-3,3-dialkyltriazenes in mice.
AID1132822Antitumor activity against mouse L1210 cells allografted in mouse assessed as increase of host lifespan1978Journal of medicinal chemistry, Jun, Volume: 21, Issue:6
Antitumor 1-(X-aryl)-3,3-dialkyltriazenes. 1. Quantitative structure-activity relationships vs. L1210 leukemia in mice.
AID1794808Fluorescence-based screening to identify small molecule inhibitors of Plasmodium falciparum apicoplast DNA polymerase (Pf-apPOL).2014Journal of biomolecular screening, Jul, Volume: 19, Issue:6
A High-Throughput Assay to Identify Inhibitors of the Apicoplast DNA Polymerase from Plasmodium falciparum.
AID1794808Fluorescence-based screening to identify small molecule inhibitors of Plasmodium falciparum apicoplast DNA polymerase (Pf-apPOL).
AID1159607Screen for inhibitors of RMI FANCM (MM2) intereaction2016Journal of biomolecular screening, Jul, Volume: 21, Issue:6
A High-Throughput Screening Strategy to Identify Protein-Protein Interaction Inhibitors That Block the Fanconi Anemia DNA Repair Pathway.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (8)

TimeframeStudies, This Drug (%)All Drugs %
pre-19905 (62.50)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's2 (25.00)24.3611
2020's1 (12.50)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.13

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.13 (24.57)
Research Supply Index2.20 (2.92)
Research Growth Index4.32 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.13)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other8 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]