Compounds > cyc 202
Page last updated: 2024-09-04

cyc 202 and sb 203580

cyc 202 has been researched along with sb 203580 in 12 studies

Compound Research Comparison

Studies
(cyc 202)		Trials
(cyc 202)		Recent Studies (post-2010)
(cyc 202)		Studies
(sb 203580)		Trials
(sb 203580)		Recent Studies (post-2010) (sb 203580)
97973933,48941,137

Protein Interaction Comparison

ProteinTaxonomycyc 202 (IC50)sb 203580 (IC50)
Citron Rho-interacting kinaseHomo sapiens (human)1
Cyclin-G-associated kinaseHomo sapiens (human)0.4133
Mitogen-activated protein kinase 13Homo sapiens (human)0.2329
Mitogen-activated protein kinase 2Pneumocystis carinii0.105
Receptor-interacting serine/threonine-protein kinase 2Homo sapiens (human)1.0359
RAF proto-oncogene serine/threonine-protein kinaseHomo sapiens (human)0.7575
Cytochrome P450 1A2Homo sapiens (human)2
Tyrosine-protein kinase LckHomo sapiens (human)3.45
Neutrophil elastaseHomo sapiens (human)0.025
Cytochrome P450 3A4Homo sapiens (human)0.062
Cytochrome P450 2D6Homo sapiens (human)2
TyrosinaseMus musculus (house mouse)0.034
Cholesteryl ester transfer proteinHomo sapiens (human)0.04
Cytochrome P450 2C9 Homo sapiens (human)1
Proto-oncogene tyrosine-protein kinase SrcHomo sapiens (human)5
Serine/threonine-protein kinase B-rafHomo sapiens (human)1
Amine oxidase [flavin-containing] BRattus norvegicus (Norway rat)0.36
Prostaglandin G/H synthase 1Homo sapiens (human)2
Thromboxane-A synthase Homo sapiens (human)0.494
Adenosine receptor A2aHomo sapiens (human)6.068
Ephrin type-B receptor 2Homo sapiens (human)7.8
Adenosine receptor A1Homo sapiens (human)2.95
Sodium-dependent serotonin transporterRattus norvegicus (Norway rat)0.01
Delta-type opioid receptorMus musculus (house mouse)0.02
Cytochrome P450 2C19Homo sapiens (human)0.8
TGF-beta receptor type-1Homo sapiens (human)6
Mitogen-activated protein kinase 9Homo sapiens (human)0.9517
Mitogen-activated protein kinase 14 Mus musculus (house mouse)0.056
Casein kinase I isoform deltaHomo sapiens (human)0.4147
Casein kinase I isoform epsilonHomo sapiens (human)1
Mitogen-activated protein kinase 12Homo sapiens (human)0.2329
Mitogen-activated protein kinase 10Homo sapiens (human)0.6933
Mitogen-activated protein kinase 1Rattus norvegicus (Norway rat)0.048
Myotonin-protein kinaseHomo sapiens (human)1
Mitogen-activated protein kinase 11Homo sapiens (human)0.2646
Mitogen-activated protein kinase 14Homo sapiens (human)0.39
P2X purinoceptor 7Homo sapiens (human)5
Serine/threonine-protein kinase 36Homo sapiens (human)1
Serine/threonine-protein kinase NLKHomo sapiens (human)1
TRAF2 and NCK-interacting protein kinaseHomo sapiens (human)1

Research

Studies (12)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's1 (8.33)18.2507
2000's5 (41.67)29.6817
2010's3 (25.00)24.3611
2020's3 (25.00)2.80

Authors

AuthorsStudies
Atteridge, CE; Azimioara, MD; Benedetti, MG; Biggs, WH; Carter, TA; Ciceri, P; Edeen, PT; Fabian, MA; Floyd, M; Ford, JM; Galvin, M; Gerlach, JL; Grotzfeld, RM; Herrgard, S; Insko, DE; Insko, MA; Lai, AG; Lélias, JM; Lockhart, DJ; Mehta, SA; Milanov, ZV; Patel, HK; Treiber, DK; Velasco, AM; Wodicka, LM; Zarrinkar, PP1
Bilter, GK; Dias, J; Huang, Z; Keon, BH; Lamerdin, J; MacDonald, ML; Michnick, SW; Minami, T; Owens, S; Shang, Z; Westwick, JK; Yu, H1
Alessi, DR; Arthur, JS; Bain, J; Cohen, P; Elliott, M; Hastie, CJ; Klevernic, I; McLauchlan, H; Plater, L; Shpiro, N1
Bullock, AN; Fedorov, O; Knapp, S; Marsden, B; Müller, S; Pogacic, V; Rellos, P; Schwaller, J; Sundström, M1
Atteridge, CE; Campbell, BT; Chan, KW; Ciceri, P; Davis, MI; Edeen, PT; Faraoni, R; Floyd, M; Gallant, P; Herrgard, S; Hunt, JP; Karaman, MW; Lockhart, DJ; Milanov, ZV; Morrison, MJ; Pallares, G; Patel, HK; Pritchard, S; Treiber, DK; Wodicka, LM; Zarrinkar, PP1
Russu, WA; Shallal, HM1
Davis, MI; Khan, J; Li, SQ; Patel, PR; Shen, M; Sun, H; Thomas, CJ1
Bharate, SB; Raghuvanshi, R1
Caballero, E; García-Cárceles, J; Gil, C; Martínez, A1
Coffey, ET; Courtney, MJ1
Chen, ZG; Huang, JL; Kong, FJ; Lu, JM; Shun, JL; Yang, BX; Zhang, HH1
Asai, T; Ikari, A; Manabe, A; Matsunaga, T; Onuma, S; Yoshino, Y1

Reviews

1 review(s) available for cyc 202 and sb 203580

ArticleYear
Kinase Inhibitors as Underexplored Antiviral Agents.
    Journal of medicinal chemistry, 2022, 01-27, Volume: 65, Issue:2

    Topics: Animals; Antiviral Agents; Drug Repositioning; Humans; Protein Kinase Inhibitors; Virus Diseases; Viruses

2022

Other Studies

11 other study(ies) available for cyc 202 and sb 203580

ArticleYear
A small molecule-kinase interaction map for clinical kinase inhibitors.
    Nature biotechnology, 2005, Volume: 23, Issue:3

    Topics: Benzamides; Drug Design; Escherichia coli; Escherichia coli Proteins; Imatinib Mesylate; Microchemistry; Pharmaceutical Preparations; Piperazines; Protein Binding; Protein Interaction Mapping; Protein Kinase Inhibitors; Pyrimidines

2005
Identifying off-target effects and hidden phenotypes of drugs in human cells.
    Nature chemical biology, 2006, Volume: 2, Issue:6

    Topics: Bacterial Proteins; Cell Line; Cell Proliferation; Cluster Analysis; Drug Design; Drug Evaluation, Preclinical; Genetics; Humans; Luminescent Proteins; Molecular Structure; Phenotype; Recombinant Fusion Proteins; Signal Transduction; Structure-Activity Relationship

2006
The selectivity of protein kinase inhibitors: a further update.
    The Biochemical journal, 2007, Dec-15, Volume: 408, Issue:3

    Topics: Amino Acid Sequence; Animals; Cell Line; Drug Design; Enzyme Activation; Humans; Mitogen-Activated Protein Kinases; Phosphorylation; Protein Kinase Inhibitors; Recombinant Proteins; Spodoptera

2007
A systematic interaction map of validated kinase inhibitors with Ser/Thr kinases.
    Proceedings of the National Academy of Sciences of the United States of America, 2007, Dec-18, Volume: 104, Issue:51

    Topics: Amino Acid Sequence; Binding Sites; Clinical Trials as Topic; Drug Evaluation, Preclinical; Enzyme Stability; Humans; Molecular Sequence Data; Phylogeny; Protein Array Analysis; Protein Conformation; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases

2007
A quantitative analysis of kinase inhibitor selectivity.
    Nature biotechnology, 2008, Volume: 26, Issue:1

    Topics: Binding Sites; Enzyme Activation; Humans; Phosphotransferases; Protein Binding; Protein Interaction Mapping; Protein Kinase Inhibitors; Proteome; Quantitative Structure-Activity Relationship

2008
Discovery, synthesis, and investigation of the antitumor activity of novel piperazinylpyrimidine derivatives.
    European journal of medicinal chemistry, 2011, Volume: 46, Issue:6

    Topics: Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Dose-Response Relationship, Drug; Drug Discovery; Drug Screening Assays, Antitumor; Humans; Models, Molecular; Molecular Structure; Piperazines; Protein Kinase Inhibitors; Protein Kinases; Pyrimidines; Stereoisomerism; Structure-Activity Relationship

2011
Identification of potent Yes1 kinase inhibitors using a library screening approach.
    Bioorganic & medicinal chemistry letters, 2013, Aug-01, Volume: 23, Issue:15

    Topics: Binding Sites; Cell Line; Cell Survival; Drug Design; Humans; Hydrogen Bonding; Molecular Docking Simulation; Protein Kinase Inhibitors; Protein Structure, Tertiary; Proto-Oncogene Proteins c-yes; Small Molecule Libraries; Structure-Activity Relationship

2013
Recent Developments in the Use of Kinase Inhibitors for Management of Viral Infections.
    Journal of medicinal chemistry, 2022, 01-27, Volume: 65, Issue:2

    Topics: Antiviral Agents; COVID-19; COVID-19 Drug Treatment; Drug Approval; Drug Repositioning; High-Throughput Screening Assays; Humans; Protein Kinase Inhibitors; SARS-CoV-2; United States; United States Food and Drug Administration; Virus Diseases

2022
The mechanism of Ara-C-induced apoptosis of differentiating cerebellar granule neurons.
    The European journal of neuroscience, 1999, Volume: 11, Issue:3

    Topics: Androstadienes; Animals; Antimetabolites, Antineoplastic; Apoptosis; Benzamides; CDC2 Protein Kinase; CDC2-CDC28 Kinases; Cell Differentiation; Cell Survival; Cerebellum; Cyclin-Dependent Kinase 2; Cyclin-Dependent Kinase 4; Cyclin-Dependent Kinase 5; Cyclin-Dependent Kinases; Cytarabine; Enzyme Inhibitors; Flavonoids; Imatinib Mesylate; Imidazoles; Mitogen-Activated Protein Kinase 12; Mitogen-Activated Protein Kinases; Neurons; Piperazines; Piperidines; Poly (ADP-Ribose) Polymerase-1; Poly(ADP-ribose) Polymerases; Protein Kinases; Protein Serine-Threonine Kinases; Proteins; Proto-Oncogene Proteins; Purines; Pyridines; Pyrimidines; Rats; Roscovitine; Signal Transduction; Stress, Physiological; Wortmannin

1999
Cdk5 contributes to inflammation-induced thermal hyperalgesia mediated by the p38 MAPK pathway in microglia.
    Brain research, 2015, Sep-04, Volume: 1619

    Topics: Animals; Cyclin-Dependent Kinase 5; Freund's Adjuvant; Hyperalgesia; Imidazoles; Male; MAP Kinase Signaling System; Microglia; Myelitis; Neurons; Purines; Pyridines; Rats; Rats, Sprague-Dawley; Roscovitine; Spinal Cord Dorsal Horn; Tumor Necrosis Factor-alpha

2015
Upregulation of Chemoresistance by Mg
    Cells, 2021, 05-12, Volume: 10, Issue:5

    Topics: A549 Cells; Adenocarcinoma of Lung; ATP Binding Cassette Transporter, Subfamily B; Cell Cycle; Cell Proliferation; Cisplatin; Cyclosporins; DNA Damage; Doxorubicin; Drug Resistance, Neoplasm; Gene Expression Regulation, Neoplastic; Humans; Imidazoles; Lung Neoplasms; Lymph Nodes; Magnesium; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Pyridines; Reactive Oxygen Species; Roscovitine

2021