Conditions > Persistent Fetal Vasculature Syndrome
Page last updated: 2024-09-27
Persistent Fetal Vasculature Syndrome
A developmental ocular anomaly in which the primary VITREOUS BODY and its surrounding hyaloid vasculature failed to regress. It is usually unilateral and characterized by CATARACT; MICROPHTHALMOS (small eyeballs), and retrolenticular fibrovascular tissue. (from Yanoff: Ophthalmology, 2nd ed.)
Synonyms(4)
Synonym |
Persistent Hyperplastic Primary Vitreous |
Persistent Hyaloid Vasculature |
Persistent Fetal Vasculature Syndrome |
Persistent Hyaloid Artery |
Research
Studies (16)
Timeframe | Studies, This Condition (%) | All Conditions % |
pre-1990 | 0 (0.00) | 23.3326 |
1990's | 0 (0.00) | 12.5806 |
2000's | 0 (0.00) | 18.1394 |
2010's | 13 (81.25) | 28.8240 |
2020's | 3 (18.75) | 9.53 |
Protein Targets (68)
Protein | Potency Measurements | Inhibition Measurements | Activation Measurements | Drugs |
hypoxia-inducible factor 1 alpha subunit | 1 | 0 | 0 | 1 |
RAR-related orphan receptor gamma | 2 | 0 | 0 | 2 |
GLI family zinc finger 3 | 2 | 0 | 0 | 2 |
AR protein | 2 | 0 | 0 | 2 |
aldehyde dehydrogenase 1 family, member A1 | 1 | 0 | 0 | 1 |
retinoic acid nuclear receptor alpha variant 1 | 2 | 0 | 0 | 2 |
retinoid X nuclear receptor alpha | 2 | 0 | 0 | 2 |
estrogen nuclear receptor alpha | 2 | 0 | 0 | 2 |
peroxisome proliferator-activated receptor delta | 2 | 0 | 0 | 2 |
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a | 2 | 0 | 0 | 2 |
activating transcription factor 6 | 1 | 0 | 0 | 1 |
v-jun sarcoma virus 17 oncogene homolog (avian) | 1 | 0 | 0 | 1 |
Histone H2A.x | 1 | 0 | 0 | 1 |
thyroid hormone receptor beta isoform a | 2 | 0 | 0 | 2 |
heat shock protein beta-1 | 1 | 0 | 0 | 1 |
nuclear factor erythroid 2-related factor 2 isoform 1 | 2 | 0 | 0 | 2 |
lamin isoform A-delta10 | 1 | 0 | 0 | 1 |
Voltage-dependent calcium channel gamma-2 subunit | 2 | 0 | 0 | 2 |
Glutamate receptor 2 | 2 | 0 | 0 | 2 |
Chain A, Beta-lactamase | 1 | 0 | 0 | 1 |
Chain A, Ferritin light chain | 1 | 0 | 0 | 1 |
glp-1 receptor, partial | 1 | 0 | 0 | 1 |
pregnane X receptor | 1 | 0 | 0 | 1 |
phosphopantetheinyl transferase | 1 | 0 | 0 | 1 |
SMAD family member 2 | 1 | 0 | 0 | 1 |
SMAD family member 3 | 1 | 0 | 0 | 1 |
TDP1 protein | 1 | 0 | 0 | 1 |
estrogen receptor 2 (ER beta) | 1 | 0 | 0 | 1 |
nuclear receptor subfamily 1, group I, member 3 | 1 | 0 | 0 | 1 |
progesterone receptor | 1 | 0 | 0 | 1 |
nonstructural protein 1 | 1 | 0 | 0 | 1 |
glucocorticoid receptor [Homo sapiens] | 1 | 0 | 0 | 1 |
estrogen-related nuclear receptor alpha | 1 | 0 | 0 | 1 |
farnesoid X nuclear receptor | 1 | 0 | 0 | 1 |
pregnane X nuclear receptor | 1 | 0 | 0 | 1 |
peroxisome proliferator activated receptor gamma | 1 | 0 | 0 | 1 |
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 1 | 0 | 0 | 1 |
aryl hydrocarbon receptor | 1 | 0 | 0 | 1 |
vitamin D3 receptor isoform VDRA | 1 | 0 | 0 | 1 |
chromobox protein homolog 1 | 1 | 0 | 0 | 1 |
thyroid hormone receptor beta isoform 2 | 1 | 0 | 0 | 1 |
heat shock protein HSP 90-alpha isoform 2 | 0 | 0 | 0 | 1 |
DNA polymerase iota isoform a (long) | 1 | 0 | 0 | 1 |
nuclear receptor ROR-gamma isoform 1 | 1 | 0 | 0 | 1 |
Polyunsaturated fatty acid lipoxygenase ALOX15B | 1 | 0 | 0 | 1 |
Cellular tumor antigen p53 | 1 | 0 | 0 | 1 |
Cytochrome P450 3A4 | 0 | 2 | 0 | 2 |
Histamine H2 receptor | 1 | 0 | 0 | 1 |
Guanine nucleotide-binding protein G | 1 | 0 | 0 | 1 |
TAR DNA-binding protein 43 | 1 | 0 | 0 | 1 |
ATPase family AAA domain-containing protein 5 | 1 | 0 | 0 | 1 |
Ataxin-2 | 1 | 0 | 0 | 1 |
heat shock protein 90, putative | 0 | 0 | 0 | 1 |
Fumarate hydratase | 1 | 0 | 0 | 1 |
EWS/FLI fusion protein | 1 | 0 | 0 | 1 |
NPYLR7B | 0 | 0 | 1 | 1 |
polyprotein | 1 | 0 | 0 | 1 |
tyrosine-protein kinase Yes | 1 | 0 | 0 | 1 |
Solute carrier family 22 member 2 | 0 | 1 | 0 | 1 |
DNA topoisomerase 1 | 0 | 1 | 2 | 4 |
DNA topoisomerase 2-alpha | 0 | 1 | 0 | 1 |
DNA topoisomerase 2-beta | 0 | 1 | 0 | 1 |
DNA topoisomerase 1 | 0 | 1 | 0 | 1 |
Hypoxia-inducible factor 1-alpha | 0 | 1 | 1 | 2 |
Multidrug and toxin extrusion protein 2 | 0 | 1 | 0 | 1 |
Multidrug and toxin extrusion protein 1 | 0 | 1 | 0 | 1 |
Endothelial PAS domain-containing protein 1 | 0 | 0 | 1 | 1 |
Broad substrate specificity ATP-binding cassette transporter ABCG2 | 0 | 1 | 0 | 1 |
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023] |