flutemetamol ((18)F) : A member of the class of benzothiazoles that is 1,3-benzothiazole substituted by 3-((18)F)fluoro-4-(methylamino)phenyl and hydroxy groups at positions 3 and 6 respectively. A positron emission tomography imaging ligand for the detection of amyloid aggregation associated with Alzheimer disease. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]
| ID Source | ID |
|---|---|
| PubMed CID | 15950376 |
| CHEMBL ID | 2042122 |
| CHEBI ID | 76611 |
| SCHEMBL ID | 10032147 |
| MeSH ID | M0594262 |
| Synonym |
|---|
| vizamyl (tn) |
| flutemetamol f 18 (usan) |
| D10231 |
| flutemetamol f18 |
| (18f)flutemetamol |
| flutemetamol (18f) |
| [18f]-flutemetamol f18 |
| (18f)ah110690 |
| CHEMBL2042122 |
| [18f]ah110690 |
| chebi:76611 , |
| flutemetamol ((18)f) |
| 2-[3-((18)f)fluoro-4-(methylamino)phenyl]-1,3-benzothiazol-6-ol |
| 765922-62-1 |
| flutemetamol ((sup 18)f) |
| flutemetamol f 18 [usan] |
| flutemetamol (18f) [inn] |
| ((18 sup)f)ah110690 |
| flutemetamol f 18 |
| 18f-flutemetamol |
| 6-benzothiazolol, 2-(3-(fluoro-(sup 18)f)-4-(methylamino)phenyl)- |
| 2-(3-((18 sup)f)fluoro-4-(methylamino)phenyl)-1,3-benzothiazol-6-ol |
| 2-(3-(sup 18)f)fluoro-4-(methylamino)phenyl)-1,3-benzothiazol-6-ol |
| unii-l49m066s0o |
| flutemetamol f-18 |
| vizamyl |
| flutemetamol ((sup18)f) |
| l49m066s0o , |
| flutemetamol f-18 [orange book] |
| ah-110690 f-18 |
| flutemetamol ((1)f) [inn] |
| (18f)flutemetamol [mi] |
| flutemetamol (18f) [who-dd] |
| gtpl7342 |
| 2-[3-(18f)fluoro-4-(methylamino)phenyl]-1,3-benzothiazol-6-ol |
| [18f]flutemetamol |
| DTXSID80227394 , |
| SCHEMBL10032147 |
| [18f]-flutemetamol |
| DB09151 |
| Q18355673 |
| 2-[3-(18f)fluoranyl-4-(methylamino)phenyl]-1,3-benzothiazol-6-ol |
| dtxcid80149885 |
| (18f)fpib |
| (18f)-flutemetamol |
| v09ax04 |
| 2-(3-(18f)fluoro-4-(methylamino)phenyl)-1,3-benzothiazol-6-ol |
| 2-(3-((18)f)fluoro-4-(methylamino)phenyl)-1,3-benzothiazol-6-ol |
| flutemetamolum (18f) |
| (18f)ge-067 |
| fluorine f 18 flutemetamol |
| Role | Description |
|---|---|
| radioactive imaging agent | null |
| [role information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res] | |
| Class | Description |
|---|---|
| (18)F radiopharmaceutical | |
| benzothiazoles | |
| aromatic amine | An amino compound in which the amino group is linked directly to an aromatic system. |
| secondary amino compound | A compound formally derived from ammonia by replacing two hydrogen atoms by organyl groups. |
| [compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res] | |
| Protein | Taxonomy | Measurement | Average | Min (ref.) | Avg (ref.) | Max (ref.) | Bioassay(s) |
|---|---|---|---|---|---|---|---|
| Amyloid-beta precursor protein | Homo sapiens (human) | Ki | 0.0007 | 0.0001 | 0.0856 | 0.8900 | AID673978 |
| [prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023] | |||||||
| Assay ID | Title | Year | Journal | Article |
|---|---|---|---|---|
| AID673978 | Binding affinity to human amyloid beta plaque | 2012 | ACS medicinal chemistry letters, Apr-12, Volume: 3, Issue:4 | The β-Amyloid Hypothesis in Alzheimer's Disease: Seeing Is Believing. |
| AID1884925 | Binding affinity to amyloid beta (unknown origin) | 2022 | Journal of medicinal chemistry, 07-14, Volume: 65, Issue:13 | Near-Infrared Fluorescent Probes as Imaging and Theranostic Modalities for Amyloid-Beta and Tau Aggregates in Alzheimer's Disease. |
| AID695043 | Binding affinity to amyloid beta (1-42) aggregates | 2012 | Journal of medicinal chemistry, Jan-26, Volume: 55, Issue:2 | Synthesis and evaluation of ¹⁸F-labeled styryltriazole and resveratrol derivatives for β-amyloid plaque imaging. |
| AID668927 | Displacement of [18F]-amyvid from amyloid-beta aggregates in alzheimer's disease patient brain homogenates after 1 hr | 2011 | Journal of medicinal chemistry, Dec-08, Volume: 54, Issue:23 | Multidentate (18)F-polypegylated styrylpyridines as imaging agents for Aβ plaques in cerebral amyloid angiopathy (CAA). |
| AID684724 | Binding affinity to beta-amyloid | 2012 | European journal of medicinal chemistry, Nov, Volume: 57 | ¹⁸F-labeled 2-phenylquinoxaline derivatives as potential positron emission tomography probes for in vivo imaging of β-amyloid plaques. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||||
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 4 (80.00) | 24.3611 |
| 2020's | 1 (20.00) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be strong demand-to-supply ratio for research on this compound.
| This Compound (45.28) All Compounds (24.57) |
| Publication Type | This drug (%) | All Drugs (%) |
|---|---|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 1 (20.00%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 4 (80.00%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||