Compounds > vernolide-a
Page last updated: 2024-11-13

vernolide-a

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

vernolide-A: antineoplastic from the plant Vernonia cinerea L. (Asteraceae); structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

FloraRankFlora DefinitionFamilyFamily Definition
VernoniagenusA plant genus of the family ASTERACEAE. Members contain germacrane and sesquiterpene LACTONES.[MeSH]AsteraceaeA large plant family of the order Asterales, subclass Asteridae, class Magnoliopsida. The family is also known as Compositae. Flower petals are joined near the base and stamens alternate with the corolla lobes. The common name of daisy refers to several genera of this family including Aster; CHRYSANTHEMUM; RUDBECKIA; TANACETUM.[MeSH]

Cross-References

ID SourceID
PubMed CID70690655
CHEMBL ID2062870
MeSH IDM0558218

Synonyms (2)

Synonym
vernolide-a
CHEMBL2062870
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (10)

Assay IDTitleYearJournalArticle
AID675155Inhibition of TNFalpha-induced NF-kappaB activity expressed in human HEK 293 cells at 50 uM after 6 hrs by luciferase reporter gene assay2012Bioorganic & medicinal chemistry letters, Sep-01, Volume: 22, Issue:17
Anti-inflammatory sesquiterpene lactones from the flower of Vernonia cinerea.
AID675153Cytotoxicity in mouse RAW264.7 cells assessed as cell survival at 50 uM2012Bioorganic & medicinal chemistry letters, Sep-01, Volume: 22, Issue:17
Anti-inflammatory sesquiterpene lactones from the flower of Vernonia cinerea.
AID675156Cytotoxicity in human HEK293 cells assessed as survival at 50 uM2012Bioorganic & medicinal chemistry letters, Sep-01, Volume: 22, Issue:17
Anti-inflammatory sesquiterpene lactones from the flower of Vernonia cinerea.
AID1252625Antiproliferative activity against human MDA-MB-231 cells at 5 uM for 72 hrs by cyquant assay2015Journal of medicinal chemistry, Oct-08, Volume: 58, Issue:19
Hirsutinolide Series Inhibit Stat3 Activity, Alter GCN1, MAP1B, Hsp105, G6PD, Vimentin, TrxR1, and Importin α-2 Expression, and Induce Antitumor Effects against Human Glioma.
AID675154Antiinflammatory activity against LPS-induced NO production in mouse RAW264.7 cells assessed as reduction in nitrite level preincubated for 15 mins prior to LPS treatment by Griess method2012Bioorganic & medicinal chemistry letters, Sep-01, Volume: 22, Issue:17
Anti-inflammatory sesquiterpene lactones from the flower of Vernonia cinerea.
AID675152Antiinflammatory activity against LPS-induced NO production in mouse RAW264.7 cells assessed as reduction in nitrite level at 50 uM preincubated for 15 mins prior to LPS treatment by Griess method2012Bioorganic & medicinal chemistry letters, Sep-01, Volume: 22, Issue:17
Anti-inflammatory sesquiterpene lactones from the flower of Vernonia cinerea.
AID1252620Antiproliferative activity against human U251MG cells at 5 uM for 72 hrs by cyquant assay2015Journal of medicinal chemistry, Oct-08, Volume: 58, Issue:19
Hirsutinolide Series Inhibit Stat3 Activity, Alter GCN1, MAP1B, Hsp105, G6PD, Vimentin, TrxR1, and Importin α-2 Expression, and Induce Antitumor Effects against Human Glioma.
AID675157Inhibition of TNFalpha-induced NF-kappaB activity expressed in human HEK 293 cells after 6 hrs by luciferase reporter gene assay2012Bioorganic & medicinal chemistry letters, Sep-01, Volume: 22, Issue:17
Anti-inflammatory sesquiterpene lactones from the flower of Vernonia cinerea.
AID1252626Antiproliferative activity against human SF295 cells at 5 uM for 72 hrs by cyquant assay2015Journal of medicinal chemistry, Oct-08, Volume: 58, Issue:19
Hirsutinolide Series Inhibit Stat3 Activity, Alter GCN1, MAP1B, Hsp105, G6PD, Vimentin, TrxR1, and Importin α-2 Expression, and Induce Antitumor Effects against Human Glioma.
AID1252627Cytotoxicity against mouse NIH/3T3 cells at 5uM after 72 hrs by cyquant cells2015Journal of medicinal chemistry, Oct-08, Volume: 58, Issue:19
Hirsutinolide Series Inhibit Stat3 Activity, Alter GCN1, MAP1B, Hsp105, G6PD, Vimentin, TrxR1, and Importin α-2 Expression, and Induce Antitumor Effects against Human Glioma.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (11)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's10 (90.91)24.3611
2020's1 (9.09)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.02

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.02 (24.57)
Research Supply Index2.48 (2.92)
Research Growth Index4.51 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.02)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews1 (9.09%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other10 (90.91%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
hydroxyproline
Hydroxyproline: A hydroxylated form of the imino acid proline. A deficiency in ASCORBIC ACID can result in impaired hydroxyproline formation.. hydroxyproline : A proline derivative that is proline substituted by at least one hydroxy group.		2.07104-hydroxyproline;
L-alpha-amino acid zwitterion		human metabolite;
mouse metabolite;
plant metabolite
paclitaxel
Taxus: Genus of coniferous yew trees or shrubs, several species of which have medicinal uses. Notable is the Pacific yew, Taxus brevifolia, which is used to make the anti-neoplastic drug taxol (PACLITAXEL).		2.1110taxane diterpenoid;
tetracyclic diterpenoid		antineoplastic agent;
human metabolite;
metabolite;
microtubule-stabilising agent
staurosporine
[no description available]		2.1110indolocarbazole alkaloid;
organic heterooctacyclic compound		apoptosis inducer;
bacterial metabolite;
EC 2.7.11.13 (protein kinase C) inhibitor;
geroprotector
n-acetylneuraminic acid
N-Acetylneuraminic Acid: An N-acyl derivative of neuraminic acid. N-acetylneuraminic acid occurs in many polysaccharides, glycoproteins, and glycolipids in animals and bacteria. (From Dorland, 28th ed, p1518). N-acetylneuraminic acid : An N-acylneuraminic acid where the N-acyl group is specified as acetyl.		2.0710N-acetylneuraminic acidsantioxidant;
bacterial metabolite;
EC 3.2.1.18 (exo-alpha-sialidase) inhibitor;
human metabolite;
mouse metabolite
tosylphenylalanyl chloromethyl ketone
Tosylphenylalanyl Chloromethyl Ketone: An inhibitor of Serine Endopeptidases. Acts as alkylating agent and is known to interfere with the translation process.. N-tosyl-L-phenylalanyl chloromethyl ketone : The N-tosyl derivative of L-phenylalanyl chloromethyl ketone.		2.0710alpha-chloroketone;
sulfonamide		alkylating agent;
serine proteinase inhibitor
sesquiterpenes
[no description available]		4.890
bay 11-7082
(E)-3-tosylacrylonitrile : A nitrile that is acrylonitrile in which the hydrogen located beta,trans to the cyano group is replaced by a tosyl group. It is an inhibitor of cytokine-induced IkappaB-alpha phosphorylation in cells.		2.0710nitrile;
sulfone		apoptosis inducer;
EC 2.7.11.10 (IkappaB kinase) inhibitor;
EC 3.1.3.48 (protein-tyrosine-phosphatase) inhibitor;
non-steroidal anti-inflammatory drug;
platelet aggregation inhibitor
ConditionIndicatedRelationship StrengthStudiesTrials
Benign Neoplasms
[description not available]		02.4720
Neoplasms
New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.		02.4720
Benign Neoplasms, Brain
[description not available]		02.1110
Glial Cell Tumors
[description not available]		02.1110
Brain Neoplasms
Neoplasms of the intracranial components of the central nervous system, including the cerebral hemispheres, basal ganglia, hypothalamus, thalamus, brain stem, and cerebellum. Brain neoplasms are subdivided into primary (originating from brain tissue) and secondary (i.e., metastatic) forms. Primary neoplasms are subdivided into benign and malignant forms. In general, brain tumors may also be classified by age of onset, histologic type, or presenting location in the brain.		02.1110
Glioma
Benign and malignant central nervous system neoplasms derived from glial cells (i.e., astrocytes, oligodendrocytes, and ependymocytes). Astrocytes may give rise to astrocytomas (ASTROCYTOMA) or glioblastoma multiforme (see GLIOBLASTOMA). Oligodendrocytes give rise to oligodendrogliomas (OLIGODENDROGLIOMA) and ependymocytes may undergo transformation to become EPENDYMOMA; CHOROID PLEXUS NEOPLASMS; or colloid cysts of the third ventricle. (From Escourolle et al., Manual of Basic Neuropathology, 2nd ed, p21)		02.1110
B16 Melanoma
[description not available]		02.9840
Metastase
[description not available]		02.0610
Neoplasm Metastasis
The transfer of a neoplasm from one organ or part of the body to another remote from the primary site.		02.0610
Innate Inflammatory Response
[description not available]		02.0610
Angiogenesis, Pathologic
[description not available]		02.4720
Inflammation
A pathological process characterized by injury or destruction of tissues caused by a variety of cytologic and chemical reactions. It is usually manifested by typical signs of pain, heat, redness, swelling, and loss of function.		02.0610
Cancer of Lung
[description not available]		02.0710
Invasiveness, Neoplasm
[description not available]		02.4720
Lung Neoplasms
Tumors or cancer of the LUNG.		02.0710
Cancer, Radiation-Induced
[description not available]		02.0610
Experimental Neoplasms
[description not available]		02.0710