| Assay ID | Title | Year | Journal | Article |
|---|
| AID1346442 | Human KCa2.2 (Calcium- and sodium-activated potassium channels) | 2010 | Progress in neurobiology, Jul, Volume: 91, Issue:3
| Small conductance calcium-activated potassium channels: from structure to function. |
| AID1346452 | Human KCa2.3 (Calcium- and sodium-activated potassium channels) | 2010 | Progress in neurobiology, Jul, Volume: 91, Issue:3
| Small conductance calcium-activated potassium channels: from structure to function. |
| AID1346438 | Rat KCa2.2 (Calcium- and sodium-activated potassium channels) | 2000 | British journal of pharmacology, Mar, Volume: 129, Issue:5
| Pharmacological characterization of small-conductance Ca(2+)-activated K(+) channels stably expressed in HEK 293 cells. |
| AID1346449 | Human KCa2.1 (Calcium- and sodium-activated potassium channels) | 2000 | British journal of pharmacology, Mar, Volume: 129, Issue:5
| Pharmacological characterization of small-conductance Ca(2+)-activated K(+) channels stably expressed in HEK 293 cells. |
| AID1346449 | Human KCa2.1 (Calcium- and sodium-activated potassium channels) | 2010 | Progress in neurobiology, Jul, Volume: 91, Issue:3
| Small conductance calcium-activated potassium channels: from structure to function. |
| AID1346463 | Rat KCa2.3 (Calcium- and sodium-activated potassium channels) | 2001 | The Journal of physiology, Sep-01, Volume: 535, Issue:Pt 2
| SK3 is an important component of K(+) channels mediating the afterhyperpolarization in cultured rat SCG neurones. |
| AID1346452 | Human KCa2.3 (Calcium- and sodium-activated potassium channels) | 2001 | The Journal of biological chemistry, Apr-13, Volume: 276, Issue:15
| Calcium-activated potassium channels sustain calcium signaling in T lymphocytes. Selective blockers and manipulated channel expression levels. |
| AID1346442 | Human KCa2.2 (Calcium- and sodium-activated potassium channels) | 2001 | The Journal of biological chemistry, Apr-13, Volume: 276, Issue:15
| Calcium-activated potassium channels sustain calcium signaling in T lymphocytes. Selective blockers and manipulated channel expression levels. |
| AID346946 | Inhibition of Wistar rat recombinant SK3 channel expressed in HEK293 cells by whole cell patch clamp technique | 2008 | Journal of medicinal chemistry, Dec-11, Volume: 51, Issue:23
| Synthesis and structure-activity relationship studies of 2-(N-substituted)-aminobenzimidazoles as potent negative gating modulators ofsmall conductance Ca2+-activated K+ channels. |
| AID242705 | Inhibition of after hyperpolarization (AHP) of cultured rat sympathetic neurons as SKCa channel blocking activity | 2004 | Bioorganic & medicinal chemistry letters, Aug-16, Volume: 14, Issue:16
| Bis-quinolinium cyclophanes: toward a pharmacophore model for the blockade of apamin-sensitive SKCa channels in sympathetic neurons. |
| AID19933 | Equieffective molar ratio is ratio of the concentration of the test compound and dequalinium that cause 50% inhibition of AHP | 2000 | Journal of medicinal chemistry, Sep-21, Volume: 43, Issue:19
| bis-Quinolinium cyclophanes: 8,14-diaza-1,7(1, 4)-diquinolinacyclotetradecaphane (UCL 1848), a highly potent and selective, nonpeptidic blocker of the apamin-sensitive Ca(2+)-activated K(+) channel. |
| AID180679 | The blocking of apamin-sensitive [Ca2+]-activated K+ (SKCa) channel was assessed by the compounds ability to inhibit the after-hyperpolarization in cultured rat superior cervical ganglion neurons | 2000 | Journal of medicinal chemistry, Feb-10, Volume: 43, Issue:3
| Synthesis, molecular modeling, and pharmacological testing of bis-quinolinium cyclophanes: potent, non-peptidic blockers of the apamin-sensitive Ca(2+)-activated K(+) channel. |
| AID754046 | Inhibition of KCa2.3 in Sprague-Dawley rat superior cervical ganglion neurons assessed as inhibition of afterhyperpolarization by electrophysiological assay relative to UCL1848 | 2013 | European journal of medicinal chemistry, May, Volume: 63 | Further studies on bis-charged tetraazacyclophanes as potent inhibitors of small conductance Ca(2+)-activated K+ channels. |
| AID289128 | Ratio of concentration drug to dequalinium to cause 50% inhibition of SKca channel-mediated after-hypepolarization in rat sympathetic neurons | 2007 | Bioorganic & medicinal chemistry, Aug-15, Volume: 15, Issue:16
| Synthesis and pharmacological testing of polyaminoquinolines as blockers of the apamin-sensitive Ca2+-activated K+ channel (SK(Ca)). |
| AID196785 | The ratio of the conc of compound to dequalinium to cause 50% inhibition of the after hyperpolarization (AHP) in cultured rat sympathetic neurones | 1998 | Journal of medicinal chemistry, Jan-01, Volume: 41, Issue:1
| Bis-quinolinium cyclophanes: 6,10-diaza-3(1,3),8(1,4)-dibenzena-1,5(1,4)- diquinolinacyclodecaphane (UCL 1684), the first nanomolar, non-peptidic blocker of the apamin-sensitive Ca(2+)-activated K+ channel. |
| AID754048 | Inhibition of KCa2.3 in Sprague-Dawley rat superior cervical ganglion neurons assessed as inhibition of afterhyperpolarization by electrophysiological assay | 2013 | European journal of medicinal chemistry, May, Volume: 63 | Further studies on bis-charged tetraazacyclophanes as potent inhibitors of small conductance Ca(2+)-activated K+ channels. |
| AID229089 | The ratio of compound concentrations and dequalinium that cause 50% inhibition of the after-hyperpolarization | 2000 | Journal of medicinal chemistry, Feb-10, Volume: 43, Issue:3
| Synthesis, molecular modeling, and pharmacological testing of bis-quinolinium cyclophanes: potent, non-peptidic blockers of the apamin-sensitive Ca(2+)-activated K(+) channel. |
| AID196786 | Compound was tested for SKCa blocking action by measuring its ability to inhibit after hyperpolarization (AHP) in cultured rat sympathetic neurones | 1998 | Journal of medicinal chemistry, Jan-01, Volume: 41, Issue:1
| Bis-quinolinium cyclophanes: 6,10-diaza-3(1,3),8(1,4)-dibenzena-1,5(1,4)- diquinolinacyclodecaphane (UCL 1684), the first nanomolar, non-peptidic blocker of the apamin-sensitive Ca(2+)-activated K+ channel. |
| AID387523 | Inhibition of Kca channel | 2008 | Bioorganic & medicinal chemistry letters, Oct-01, Volume: 18, Issue:19
| Initial SAR studies on apamin-displacing 2-aminothiazole blockers of calcium-activated small conductance potassium channels. |
| AID180690 | tested for their ability to inhibit the after- hyperpolarization in cultured rat sympathetic neurons | 2000 | Journal of medicinal chemistry, Sep-21, Volume: 43, Issue:19
| bis-Quinolinium cyclophanes: 8,14-diaza-1,7(1, 4)-diquinolinacyclotetradecaphane (UCL 1848), a highly potent and selective, nonpeptidic blocker of the apamin-sensitive Ca(2+)-activated K(+) channel. |
| AID346945 | Displacement of [I125]apamine from Wistar rat recombinant SK3 channel expressed in HEK293 cells | 2008 | Journal of medicinal chemistry, Dec-11, Volume: 51, Issue:23
| Synthesis and structure-activity relationship studies of 2-(N-substituted)-aminobenzimidazoles as potent negative gating modulators ofsmall conductance Ca2+-activated K+ channels. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |