tan-1057a has been researched along with Sepsis* in 1 studies
1 other study(ies) available for tan-1057a and Sepsis
Article | Year |
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Novel antibiotics for the treatment of gram-positive bacterial infections.
The natural dipeptide antibiotic TAN 1057 A,B displays excellent antibacterial activity against staphylococci including methicillin resistant Staphylococcus aureus. However, the in vitro activity against additional Gram-positive strains, in particular pneumococci and Enterococcus faecalis, proved to be considerably lower. We report the synthesis and pharmacological evaluation of new derivatives of this natural product that displayed increased antibacterial potency against staphylococci and were also active against pneumococci. In particular, the analogues bearing modified beta-homoarginine side chains with methylated guanidine moieties were shown to be significantly more potent than the natural product TAN 1057 A,B. Topics: Animals; Anti-Bacterial Agents; Arginine; Dipeptides; Female; Gram-Positive Bacteria; Guanidines; Mice; Microbial Sensitivity Tests; Pyrimidinones; Sepsis; Staphylococcus; Streptococcus pneumoniae; Structure-Activity Relationship | 2002 |