Compounds > synerazol
Page last updated: 2024-12-11

synerazol

Description

synerazol: from Aspergillus fumigatus; structure given in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID11165858
CHEMBL ID473144
MeSH IDM0188237

Synonyms (3)

Synonym
synerazol
CHEMBL473144
(5s,8s,9r)-8-benzoyl-2-[(2s,3r)-3-[(z)-but-1-enyl]oxiran-2-yl]-9-hydroxy-8-methoxy-3-methyl-1-oxa-7-azaspiro[4.4]non-2-ene-4,6-dione
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (5)

Assay IDTitleYearJournalArticle
AID394967Inhibition of IL4 and LPS-induced IgE production in BALB/c mouse spleen B cell after 6 days by ELISA2009Bioorganic & medicinal chemistry letters, Mar-01, Volume: 19, Issue:5
Pseurotin A and its analogues as inhibitors of immunoglobulin E [correction of immunoglobuline E] production.
AID394968Immunosuppressive activity in rat lymphocytes assessed as inhibition of mixed-lymphocyte reaction2009Bioorganic & medicinal chemistry letters, Mar-01, Volume: 19, Issue:5
Pseurotin A and its analogues as inhibitors of immunoglobulin E [correction of immunoglobuline E] production.
AID394971Cytotoxicity against BALB/c mouse B cells assessed as cell viability2009Bioorganic & medicinal chemistry letters, Mar-01, Volume: 19, Issue:5
Pseurotin A and its analogues as inhibitors of immunoglobulin E [correction of immunoglobuline E] production.
AID394969Inhibition of PHA-induced BALB/c mouse T cell proliferation at 10 uM2009Bioorganic & medicinal chemistry letters, Mar-01, Volume: 19, Issue:5
Pseurotin A and its analogues as inhibitors of immunoglobulin E [correction of immunoglobuline E] production.
AID394970Cytotoxicity against human K562 cells2009Bioorganic & medicinal chemistry letters, Mar-01, Volume: 19, Issue:5
Pseurotin A and its analogues as inhibitors of immunoglobulin E [correction of immunoglobuline E] production.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (6)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's1 (16.67)18.2507
2000's5 (83.33)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other6 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
clotrimazole
[no description available]		1.9710conazole antifungal drug;
imidazole antifungal drug;
imidazoles;
monochlorobenzenes		antiinfective agent;
environmental contaminant;
xenobiotic
prednisolone
Prednisolone: A glucocorticoid with the general properties of the corticosteroids. It is the drug of choice for all conditions in which routine systemic corticosteroid therapy is indicated, except adrenal deficiency states.. prednisolone : A glucocorticoid that is prednisone in which the oxo group at position 11 has been reduced to the corresponding beta-hydroxy group. It is a drug metabolite of prednisone.		2.051011beta-hydroxy steroid;
17alpha-hydroxy steroid;
20-oxo steroid;
21-hydroxy steroid;
3-oxo-Delta(1),Delta(4)-steroid;
C21-steroid;
glucocorticoid;
primary alpha-hydroxy ketone;
tertiary alpha-hydroxy ketone		adrenergic agent;
anti-inflammatory drug;
antineoplastic agent;
drug metabolite;
environmental contaminant;
immunosuppressive agent;
xenobiotic
gliotoxin
Gliotoxin: A fungal toxin produced by various species of Trichoderma, Gladiocladium fimbriatum, Aspergillus fumigatus, and Penicillium. It is used as an immunosuppressive agent.. gliotoxin : A pyrazinoindole with a disulfide bridge spanning a dioxo-substituted pyrazine ring; mycotoxin produced by several species of fungi.		7.0210dipeptide;
organic disulfide;
organic heterotetracyclic compound;
pyrazinoindole		antifungal agent;
EC 2.5.1.58 (protein farnesyltransferase) inhibitor;
immunosuppressive agent;
mycotoxin;
proteasome inhibitor
4-butyrolactone
4-Butyrolactone: One of the FURANS with a carbonyl thereby forming a cyclic lactone. It is an endogenous compound made from gamma-aminobutyrate and is the precursor of gamma-hydroxybutyrate. It is also used as a pharmacological agent and solvent.. tetrahydrofuranone : Any oxolane having an oxo- substituent at any position on the tetrahydrofuran ring.. gamma-butyrolactone : A butan-4-olide that is tetrahydrofuran substituted by an oxo group at position 2.		2.0410butan-4-olidemetabolite;
neurotoxin
fluorides
[no description available]		2.0210halide anion;
monoatomic fluorine
pseurotin
pseurotin: metabolite isolated from culture filtrates of Pseudeurotium ovalis Stolk; structure. pseurotin A : A spirocyclic that is 1-oxa-7-azaspiro[4.4]non-2-ene-4,6-dione bearing 1,2-dihydroxyhex-3-en-1-yl, methyl, methoxy, benzoyl and hydroxy substituents at positions 2, 3, 8, 8 and 9 respectively.		2.7330azaspiro compound;
lactam;
oxaspiro compound		metabolite
ConditionIndicatedRelationship StrengthStudiesTrials
chemdatabank.com