stemoninine has been researched along with Cough* in 2 studies
2 other study(ies) available for stemoninine and Cough
| Article | Year |
|---|---|
[Comparative study of four alkaloids contents and antitussive activities of Stemona tuberosa from different habitats of Guangxi Province].
To compare the contents of four alkaloids and antitussive activities of Stemona tuberosa from different habitats of Guangxi Province.. The HPLC separation was performed on a Merck Purospher STAR RP18 (250 mm x 4. 6 mm, 5 µm) column by gradient elution using 0. 05% ammonia-acetonitrile as the mobile phase. The flow rate was 1. 0 mL/min, the dectection wave-length was set at 210 nm,and the column temperature was 40 °C. The antitussive potency of total alkaloids of Stemonae Radix from different habitats was evaluated on guinea pigs with citric acid aerosol to induce cough.. The range of recoveries of this mehtod was 98. 24% ~ 101. 21%, with all the constituents showing good linearity(the correlation coefficents above 0. 999). The major chemotype of Stemonae Radix in Guangxi was stemoninine, following by tuberostemonine and croomine, and finally neotuberostemonine. The antitussive activitiy of Stemona tuberosa was in a concentration-dependent manner.. Stemonae Radix from Dongxing, Fangcheng can reduce cough times and prolong cough incubation period, and thus Dongxing, Fangcheng is the best habitat in Guangxi in the present experiments. Topics: Alkaloids; Animals; Antitussive Agents; China; Chromatography, High Pressure Liquid; Cough; Drugs, Chinese Herbal; Ecosystem; Guinea Pigs; Heterocyclic Compounds, 3-Ring; Lactones; Plant Roots; Pyrrolidines; Spiro Compounds; Stemonaceae | 2014 |
Antitussive stemoninine alkaloids from the roots of Stemona tuberosa.
Investigation of the roots of Stemona tuberosa afforded five minor constituents, stemoenonine (1), 9a- O-methylstemoenonine (2), oxystemoenonine (3), 1,9a- seco-stemoenonine (4), and oxystemoninine (5), along with the known compound stemoninoamide (6). Their structures were elucidated by 1D and 2D NMR spectra and other spectroscopic studies. Alkaloids 1, 2, and 6, as well as the representative stemoninine-type alkaloid, stemoninine (7), were screened for antitussive activity in the citric acid-induced guinea pig cough model. Compounds 6 and 7 exhibited strong antitussive activity after oral and intraperitoneal administrations. Topics: Alkaloids; Animals; Antitussive Agents; Cough; Disease Models, Animal; Drugs, Chinese Herbal; Guinea Pigs; Molecular Structure; Nuclear Magnetic Resonance, Biomolecular; Plant Roots; Plants, Medicinal; Stemonaceae | 2008 |