Page last updated: 2024-12-11
sinococuline
Description
Research Excerpts
Clinical Trials
Roles
Classes
Pathways
Study Profile
Bioassays
Related Drugs
Related Conditions
Protein Interactions
Research Growth
Description
sinococuline: isolated from Stephania sutchuenensis; RN given for (6beta,7beta,9alpha,13alpha)-isomer; structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
Related Flora
| Flora | Rank | Flora Definition | Family | Family Definition |
|---|---|---|---|---|
| Stephania | genus | A plant genus of the family MENISPERMACEAE. Members contain cycleanine.[MeSH] | Asteraceae | A large plant family of the order Asterales, subclass Asteridae, class Magnoliopsida. The family is also known as Compositae. Flower petals are joined near the base and stamens alternate with the corolla lobes. The common name of daisy refers to several genera of this family including Aster; CHRYSANTHEMUM; RUDBECKIA; TANACETUM.[MeSH] |
| Stephania | genus | A plant genus of the family MENISPERMACEAE. Members contain cycleanine.[MeSH] | Menispermaceae | A plant family of the order Ranunculales, subclass Magnoliidae, class Magnoliopsida. Members are mostly vines and shrubs and they contain isoquinoline alkaloids, some of which have been used as arrow poisons.[MeSH] |
Cross-References
| ID Source | ID |
|---|---|
| PubMed CID | 5489400 |
| CHEMBL ID | 524026 |
| SCHEMBL ID | 166476 |
| MeSH ID | M0260247 |
Synonyms (19)
| Synonym |
|---|
| sinococuline |
| bdbm50260779 |
| CHEMBL524026 , |
| j5624pb437 , |
| 109351-36-2 |
| unii-j5624pb437 |
| (6beta,7beta,9alpha,13alpha)-8,14-didehydro-3,8-dimethoxymorphinan-4,6,7-triol |
| morphinan-4,6,7-triol, 8,14-didehydro-3,8-dimethoxy-, (6beta,7beta,9alpha,13alpha)- |
| SCHEMBL166476 |
| DTXSID00911127 |
| (1s,9s,12s,13s)-4,11-dimethoxy-17-azatetracyclo[7.5.3.01,10.02,7]heptadeca-2(7),3,5,10-tetraene-3,12,13-triol |
| Q15427859 |
| morphinan-4,6,7-triol, 8,14-didehydro-3,8-dimethoxy-, (6.beta.,7.beta.,9.alpha.,13.alpha.)- |
| alkaloid fk1000 |
| fk-1000 |
| (1s,9s,12s,13s)-4,11-dimethoxy-17-azatetracyclo(7.5.3.0^(1,10).0^(2,7))heptadeca-2(7),3,5,10-tetraene-3,12,13-triol |
| (6.beta.,7.beta.,9.alpha.,13.alpha.)-8,14-didehydro-3,8-dimethoxymorphinan-4,6,7-triol |
| AKOS040763319 |
| F92832 |
Research Excerpts
Overview
Sinococuline is an effective tumor cell growth inhibitor. The toxicity of aknadinine and 1-nitroaknadinine towards all tested cells is low.
| Excerpt | Reference | Relevance |
|---|---|---|
| "Sinococuline is an effective tumor cell growth inhibitor whereas the toxicity of aknadinine and 1-nitroaknadinine towards all tested cells is low." | ( Cytotoxic effects of sinococuline. Che, CT; Liu, WK; Wang, XK, 1996) | 1.33 |
Treatment
| Excerpt | Reference | Relevance |
|---|---|---|
| "The treatment with Sinococuline at 2.0 mg/kg/day; BID (twice a day), was the most effective in protecting the severely DENV-infected AG129 mice." | ( Sinococuline, a bioactive compound of Cocculus hirsutus has potent anti-dengue activity. Aggarwal, C; Ahuja, R; Arora, U; Beesetti, H; Chaturvedi, S; Garg, A; Khanna, N; Lal, AA; Nayyar, K; Shukla, R, 2023) | 2.67 |
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
Protein Targets (1)
Inhibition Measurements
| Protein | Taxonomy | Measurement | Average | Min (ref.) | Avg (ref.) | Max (ref.) | Bioassay(s) |
|---|---|---|---|---|---|---|---|
| Delta-type opioid receptor | Homo sapiens (human) | IC50 (µMol) | 37.0000 | 0.0002 | 0.7521 | 8.0140 | AID480387 |
| [prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023] | |||||||
Biological Processes (19)
Molecular Functions (5)
| Process | via Protein(s) | Taxonomy |
|---|---|---|
| G protein-coupled opioid receptor activity | Delta-type opioid receptor | Homo sapiens (human) |
| protein binding | Delta-type opioid receptor | Homo sapiens (human) |
| receptor serine/threonine kinase binding | Delta-type opioid receptor | Homo sapiens (human) |
| G protein-coupled enkephalin receptor activity | Delta-type opioid receptor | Homo sapiens (human) |
| neuropeptide binding | Delta-type opioid receptor | Homo sapiens (human) |
| [Information is prepared from geneontology information from the June-17-2024 release] | ||
Ceullar Components (9)
| Process | via Protein(s) | Taxonomy |
|---|---|---|
| plasma membrane | Delta-type opioid receptor | Homo sapiens (human) |
| synaptic vesicle membrane | Delta-type opioid receptor | Homo sapiens (human) |
| dendrite membrane | Delta-type opioid receptor | Homo sapiens (human) |
| presynaptic membrane | Delta-type opioid receptor | Homo sapiens (human) |
| axon terminus | Delta-type opioid receptor | Homo sapiens (human) |
| spine apparatus | Delta-type opioid receptor | Homo sapiens (human) |
| postsynaptic density membrane | Delta-type opioid receptor | Homo sapiens (human) |
| neuronal dense core vesicle | Delta-type opioid receptor | Homo sapiens (human) |
| plasma membrane | Delta-type opioid receptor | Homo sapiens (human) |
| neuron projection | Delta-type opioid receptor | Homo sapiens (human) |
| [Information is prepared from geneontology information from the June-17-2024 release] | ||
Bioassays (6)
| Assay ID | Title | Year | Journal | Article |
|---|---|---|---|---|
| AID480389 | Displacement of [3H]naloxone from kappa opioid receptor expressed in HEK293 cell membrane at 10 uM | 2010 | Journal of natural products, May-28, Volume: 73, Issue:5 | Hasubanan alkaloids with delta-opioid binding affinity from the aerial parts of Stephania japonica. |
| AID480388 | Displacement of [3H]naloxone from mu opioid receptor expressed in CHO cell membrane at 10 uM | 2010 | Journal of natural products, May-28, Volume: 73, Issue:5 | Hasubanan alkaloids with delta-opioid binding affinity from the aerial parts of Stephania japonica. |
| AID408670 | Selectivity index, ratio of TC50 for primary mice (Mus musculus) hepatocytes to IC50 for Plasmodium yoelii yoelii 265 BY liver stage sporozoites | 2008 | Bioorganic & medicinal chemistry, Jun-01, Volume: 16, Issue:11 | Isolation and antimalarial activity of new morphinan alkaloids on Plasmodium yoelii liver stage. |
| AID480387 | Displacement of [3H]deltorphin-2 from human delta opioid receptor expressed in HEK293 cell membrane | 2010 | Journal of natural products, May-28, Volume: 73, Issue:5 | Hasubanan alkaloids with delta-opioid binding affinity from the aerial parts of Stephania japonica. |
| AID408668 | Antimalarial activity against Plasmodium yoelii 265 sporozoites in primary mice (Mus musculus) hepatocytes after 48 hrs | 2008 | Bioorganic & medicinal chemistry, Jun-01, Volume: 16, Issue:11 | Isolation and antimalarial activity of new morphinan alkaloids on Plasmodium yoelii liver stage. |
| AID408669 | Cytotoxicity against primary mouse hepatocytes after 48 hrs by neutral red assay | 2008 | Bioorganic & medicinal chemistry, Jun-01, Volume: 16, Issue:11 | Isolation and antimalarial activity of new morphinan alkaloids on Plasmodium yoelii liver stage. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||||
Research
Studies (6)
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (16.67) | 18.2507 |
| 2000's | 2 (33.33) | 29.6817 |
| 2010's | 1 (16.67) | 24.3611 |
| 2020's | 2 (33.33) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
Study Types
| Publication Type | This drug (%) | All Drugs (%) |
|---|---|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 0 (0.00%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 6 (100.00%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||