Page last updated: 2024-11-09

serine methyl ester

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth

Description

serine methyl ester: RN given for (HCl, (L)-isomer) [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID2723731
CHEMBL ID440577
SCHEMBL ID159223
MeSH IDM0391349

Synonyms (23)

Synonym
serine methyl ester
l-serine methyl ester
CHEMBL440577
methyl (2s)-2-amino-3-hydroxypropanoate
2788-84-3
(s)-methyl 2-amino-3-hydroxypropanoate
(s)-2-amino-3-hydroxy-propionic acid methyl ester
h-ser-ome
(s)-methyl-2-amino-3-hydroxypropanoate
(5)-methyl 2-amino-3-hydroxypropanoate
h-ser-och3
(l)-serine methyl ester
SCHEMBL159223
l-serine, methyl ester
methyl l-serinate
l-serinemethylester
AKOS025312417
methyl (2~{s})-2-azanyl-3-oxidanyl-propanoate
(s)-methyl serinate
mfcd07783983
Q27455967
AB7436
EN300-97458

Research Excerpts

Bioavailability

ExcerptReferenceRelevance
" Our results suggest that L-valine is a desirable L-amino acid for the esterification of poorly permeable drugs to enhance their oral bioavailability targeting intestinal PEPT1."( Recognition of L-amino acid ester compounds by rat peptide transporters PEPT1 and PEPT2.
Hashimoto, Y; Inui, KI; Saito, H; Sawada, K; Terada, T, 1999
)
0.3
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Protein Targets (1)

Other Measurements

ProteinTaxonomyMeasurementAverageMin (ref.)Avg (ref.)Max (ref.)Bioassay(s)
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (7)

Assay IDTitleYearJournalArticle
AID71705Kinetic constant acting as acceptor substrate for gamma-GGT (Glutamyltranspeptidase)-mediated transpeptidation was determined in rat kidney (units are 10e3/min)2003Bioorganic & medicinal chemistry letters, Mar-24, Volume: 13, Issue:6
Synthesis of aza and oxaglutamyl-p-nitroanilide derivatives and their kinetic studies with gamma-glutamyltranspeptidase.
AID229563Ratio of kinetic constant (Kcat/KM) acting as donor substrate for gamma-GGT (Glutamyltranspeptidase)-mediated transpeptidation was determined in rat kidney; Not applicable2003Bioorganic & medicinal chemistry letters, Mar-24, Volume: 13, Issue:6
Synthesis of aza and oxaglutamyl-p-nitroanilide derivatives and their kinetic studies with gamma-glutamyltranspeptidase.
AID679857TP_TRANSPORTER: inhibition of Gly-Sar uptake (Gly-Sar: 20 uM, Ser-OMe: 10000 uM) in PEPT1-expressing LLC-PK1 cells1999The Journal of pharmacology and experimental therapeutics, Nov, Volume: 291, Issue:2
Recognition of L-amino acid ester compounds by rat peptide transporters PEPT1 and PEPT2.
AID71596Kinetic constant acting as acceptor substrate for gamma-GGT (Glutamyltranspeptidase)-mediated transpeptidation was determined in rat kidney2003Bioorganic & medicinal chemistry letters, Mar-24, Volume: 13, Issue:6
Synthesis of aza and oxaglutamyl-p-nitroanilide derivatives and their kinetic studies with gamma-glutamyltranspeptidase.
AID229380Ratio of kinetic constant (Kcat/KM) acting as acceptor substrate for gamma-GGT (Glutamyltranspeptidase)-mediated transpeptidation was determined in rat kidney2003Bioorganic & medicinal chemistry letters, Mar-24, Volume: 13, Issue:6
Synthesis of aza and oxaglutamyl-p-nitroanilide derivatives and their kinetic studies with gamma-glutamyltranspeptidase.
AID71710Kinetic constant acting as donor substrate for gamma-GGT (Glutamyltranspeptidase)-mediated transpeptidation was determined in rat kidney (units are 10e3/min); Not applicable2003Bioorganic & medicinal chemistry letters, Mar-24, Volume: 13, Issue:6
Synthesis of aza and oxaglutamyl-p-nitroanilide derivatives and their kinetic studies with gamma-glutamyltranspeptidase.
AID71702Kinetic constant acting as donor substrate for gamma-GGT (Glutamyltranspeptidase)-mediated transpeptidation was determined in rat kidney; Not applicable2003Bioorganic & medicinal chemistry letters, Mar-24, Volume: 13, Issue:6
Synthesis of aza and oxaglutamyl-p-nitroanilide derivatives and their kinetic studies with gamma-glutamyltranspeptidase.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (11)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's1 (9.09)18.2507
2000's6 (54.55)29.6817
2010's2 (18.18)24.3611
2020's2 (18.18)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other11 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]