serine-methyl-ester and serine-hydroxamate

serine-methyl-ester has been researched along with serine-hydroxamate* in 1 studies

Other Studies

1 other study(ies) available for serine-methyl-ester and serine-hydroxamate

ArticleYear
Selective inhibition of divergent seryl-tRNA synthetases by serine analogues.
    FEBS letters, 2005, Aug-15, Volume: 579, Issue:20

    Seryl-tRNA synthetases (SerRSs) fall into two distinct evolutionary groups of enzymes, bacterial and methanogenic. These two types of SerRSs display only minimal sequence similarity, primarily within the class II conserved motifs, and possess distinct modes of tRNA(Ser) recognition. In order to determine whether the two types of SerRSs also differ in their recognition of the serine substrate, we compared the sensitivity of the representative methanogenic and bacterial-type SerRSs to serine hydroxamate and two previously unidentified inhibitors, serinamide and serine methyl ester. Our kinetic data showed selective inhibition of the methanogenic SerRS by serinamide, suggesting a lack of mechanistic uniformity in serine recognition between the evolutionarily distinct SerRSs.

    Topics: Amino Acid Sequence; Archaeal Proteins; Bacterial Proteins; Enzyme Inhibitors; Escherichia coli; Methanosarcina barkeri; Molecular Sequence Data; Phylogeny; Serine; Serine-tRNA Ligase; Substrate Specificity

2005