Page last updated: 2024-11-06

isoleucine methyl ester

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Isoleucine methyl ester is a derivative of the essential amino acid isoleucine, formed by esterification of the carboxyl group with methanol. It is a colorless liquid that is soluble in organic solvents but poorly soluble in water. The compound is often used as a starting material in the synthesis of other amino acid derivatives and peptides. Its importance lies in its ability to serve as a building block for various bioactive molecules, including pharmaceuticals, agrochemicals, and biomaterials. Research on isoleucine methyl ester is motivated by its potential applications in these fields. For instance, it has been investigated for its potential in peptide synthesis, as a precursor for the production of therapeutic peptides, and as a component in biocompatible materials. The synthesis of isoleucine methyl ester typically involves the reaction of isoleucine with methanol in the presence of an acid catalyst, such as hydrochloric acid.'

Cross-References

ID SourceID
PubMed CID75735
CHEMBL ID1229072
SCHEMBL ID76741
MeSH IDM0152206

Synonyms (28)

Synonym
2577-46-0
einecs 219-931-0
isoleucine methyl ester
(2s,3s)-2-amino-3-methyl-pentanoic acid methyl ester
methyl l-isoleucinate
AKOS000302175
l-isoleucine methyl ester
methyl (2s,3s)-2-amino-3-methylpentanoate
(2s,3s)-methyl 2-amino-3-methylpentanoate
CHEMBL1229072
SCHEMBL76741
isoleucine, methyl ester
l-isoleucine, methyl ester
(l)-isoleucine methyl ester
isoleucine, methyl ester, l-
methyl 2-amino-3-methylpentanoate #
(2r,3s)-methyl 2-amino-3-methylpentanoate
J-521918
(2s,3s)-methyl-2-amino-3-methylpentanoate
Q27461445
AMY13603
E78452
methyl 2-amino-3-methylpentanoate, hcl
DTXSID40948634
(2s,3s)-2-amino-3-methylpentanoic acid methyl ester
A898353
EN300-58836
(2s,3s)-2-amino-3-methyl-pentanoic acidmethyl ester

Research Excerpts

Bioavailability

ExcerptReferenceRelevance
" Our results suggest that L-valine is a desirable L-amino acid for the esterification of poorly permeable drugs to enhance their oral bioavailability targeting intestinal PEPT1."( Recognition of L-amino acid ester compounds by rat peptide transporters PEPT1 and PEPT2.
Hashimoto, Y; Inui, KI; Saito, H; Sawada, K; Terada, T, 1999
)
0.3
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (2)

Assay IDTitleYearJournalArticle
AID678877TP_TRANSPORTER: inhibition of Gly-Sar uptake (Gly-Sar: 20 uM, Ile-OMe: 10000 uM) in PEPT2-expressing LLC-PK1 cells1999The Journal of pharmacology and experimental therapeutics, Nov, Volume: 291, Issue:2
Recognition of L-amino acid ester compounds by rat peptide transporters PEPT1 and PEPT2.
AID679860TP_TRANSPORTER: inhibition of Gly-Sar uptake (Gly-Sar: 20 uM, Ile-OMe: 10000 uM) in PEPT1-expressing LLC-PK1 cells1999The Journal of pharmacology and experimental therapeutics, Nov, Volume: 291, Issue:2
Recognition of L-amino acid ester compounds by rat peptide transporters PEPT1 and PEPT2.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (5)

TimeframeStudies, This Drug (%)All Drugs %
pre-19901 (20.00)18.7374
1990's2 (40.00)18.2507
2000's2 (40.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 20.38

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index20.38 (24.57)
Research Supply Index1.79 (2.92)
Research Growth Index4.54 (4.65)
Search Engine Demand Index15.26 (26.88)
Search Engine Supply Index2.00 (0.95)

This Compound (20.38)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other5 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]