Page last updated: 2024-12-11

rep8839

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Description

REP8839: Antibacterial; a topical synthetic fluorovinylthiophene-containing diaryldiamine that inhibits bacterial methionyl tRNA synthetase; structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID Source	ID
PubMed CID	9868368
CHEMBL ID	1631216
SCHEMBL ID	14174629
MeSH ID	M0527986

Synonyms (33)

Synonym
bdbm50333116
2-(3-((4-bromo-5-(1-fluorovinyl)-3-methylthiophen-2-yl)methylamino)propylamino)quinolin-4(1h)-one
sb-682150
bederocin
rep-8839
D09324
757942-43-1
bederocin (usan/inn)
rep 8839
rep8839
CHEMBL1631216 ,
bederocin [usan:inn]
4(1h)-quinolinone, 2-((3-(((4-bromo-5-(1-fluoroethenyl)-3-methyl-2-thienyl)methyl) mino)propyl)amino)-
yv7qd1sj9o ,
unii-yv7qd1sj9o
2-((3-(((4-bromo-5-(1-fluoroethenyl)-3-methylthiophen-2-yl)ethyl)mino)ropyl)ino)quinolin-4(1h)-one
bederocin [who-dd]
2-((3-(((4-bromo-5-(1-fluoroethenyl)-3-methylthiophen-2- yl)methyl)amino)propyl)amino)quinolin-4(1h)-one
bederocin [inn]
4(1h)-quinolinone, 2-((3-(((4-bromo-5-(1-fluoroethenyl)-3-methyl-2- thienyl)methyl)amino)propyl)amino)-
bederocin [usan]
SCHEMBL14174629
DTXSID20226705
NCGC00386616-01
2-{[3-({[4-bromo-5-(1-fluoroethenyl)-3-methylthiophen-2-yl]methyl}amino)propyl]amino}quinolin-4(1h)-one
u7s ,
2-[3-[[4-bromo-5-(1-fluoroethenyl)-3-methylthiophen-2-yl]methylamino]propylamino]-1h-quinolin-4-one
gtpl10764
Q27294730
2-((3-(((4-bromo-5-(1-fluorovinyl)-3-methylthiophen-2-yl)methyl)amino)propyl)amino)quinolin-4(1h)-one
E98874
4(1h)-quinolinone,2-[[3-[[[4-bromo-5-(1-fluoroethenyl)-3-methyl-2-thienyl]methyl]amino]propyl]amino]-
AKOS040750719

Research Excerpts

Overview

REP8839 is a selective inhibitor of methionyl-tRNA synthetase (MetRS) with antibacterial activity against a variety of gram-positive organisms.

Excerpt	Reference	Relevance
"REP8839 is a selective inhibitor of methionyl-tRNA synthetase (MetRS) with antibacterial activity against a variety of gram-positive organisms. "	( Inhibition of methionyl-tRNA synthetase by REP8839 and effects of resistance mutations on enzyme activity. Ayers, DF; Bullard, JM; Dean, F; Green, LS; Janjic, N; Jarvis, TC; Ochsner, UA; Ribble, W, 2009)	2.06
"REP8839 is a synthetic fluorovinylthiophene-containing diaryldiamine that inhibits bacterial methionyl tRNA synthetase (MetRS) and is a new chemical entity that represents a novel pharmacological class. "	( Recent advances in the preclinical evaluation of the topical antibacterial agent REP8839. Critchley, IA; Ochsner, UA, 2008)	2.01

Compound-Compound Interactions

Excerpt	Reference	Relevance
"The purpose of this study was to evaluate the potential irritating effects and the systemic exposure level of an antibacterial ointment containing REP8839 as a single agent or in combination with mupirocin versus Bactroban Nasal in rabbits."	( An intranasal irritation assessment of antibacterial ointment alone or in combination with mupirocin versus Bactroban Nasal in rabbits. Bell, SJ; Colagiovanni, DB; Faqi, AS; Gill, S, 2009)	0.55

Bioavailability

Excerpt	Reference	Relevance
" This is followed by a discussion on more recent developments in the field and the bioavailability problem."	( Aminoacyl-tRNA synthetase inhibitors as potential antibiotics. Van Aerschot, A; Vondenhoff, GH, 2011)	0.37
"The ATP-binding cassette transporter P-glycoprotein (P-gp) is known to limit both brain penetration and oral bioavailability of many chemotherapy drugs."	( A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. Ambudkar, SV; Brimacombe, KR; Chen, L; Gottesman, MM; Guha, R; Hall, MD; Klumpp-Thomas, C; Lee, OW; Lee, TD; Lusvarghi, S; Robey, RW; Shen, M; Tebase, BG, 2019)	0.51

[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Protein Targets (11)

Potency Measurements

Protein	Taxonomy	Measurement	Average (µ)	Min (ref.)	Avg (ref.)	Max (ref.)	Bioassay(s)
cytochrome P450 family 3 subfamily A polypeptide 4	Homo sapiens (human)	Potency	2.6837	0.0123	7.9835	43.2770	AID1645841
G	Vesicular stomatitis virus	Potency	2.1317	0.0123	8.9648	39.8107	AID1645842
cytochrome P450 2D6	Homo sapiens (human)	Potency	1.0684	0.0010	8.3798	61.1304	AID1645840
Interferon beta	Homo sapiens (human)	Potency	2.1317	0.0033	9.1582	39.8107	AID1645842
HLA class I histocompatibility antigen, B alpha chain	Homo sapiens (human)	Potency	2.1317	0.0123	8.9648	39.8107	AID1645842
Inositol hexakisphosphate kinase 1	Homo sapiens (human)	Potency	2.1317	0.0123	8.9648	39.8107	AID1645842
cytochrome P450 2C9, partial	Homo sapiens (human)	Potency	2.1317	0.0123	8.9648	39.8107	AID1645842
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Inhibition Measurements

Protein	Taxonomy	Measurement	Average	Min (ref.)	Avg (ref.)	Max (ref.)	Bioassay(s)
Methionine--tRNA ligase	Haemophilus influenzae Rd KW20	Ki	0.2250	0.2250	0.2250	0.2250	AID545000
Methionine--tRNA ligase	Staphylococcus aureus subsp. aureus MW2	Ki	0.3010	0.0000	0.3010	1.9000	AID541268; AID541269; AID541318; AID541319; AID541320; AID541321; AID541322; AID541323; AID541324; AID541325; AID541337
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Other Measurements

Protein	Taxonomy	Measurement	Average	Min (ref.)	Avg (ref.)	Max (ref.)	Bioassay(s)
Methionine--tRNA ligase	Geobacillus stearothermophilus	Km	3.5000	1.0000	3.5000	6.0000	AID541274; AID541281
Methionine--tRNA ligase	Staphylococcus aureus subsp. aureus MW2	Km	414.4612	0.2700	2.0200	10.0000	AID541282; AID541283; AID541284; AID541285; AID541286; AID541287; AID541288; AID541289; AID541290; AID541291; AID541292; AID541293; AID541294; AID541295; AID541296; AID541297; AID541298; AID541299; AID541300; AID541301; AID541302; AID541303; AID541336; AID541550; AID541551; AID541552; AID541553; AID541578; AID541579; AID541580; AID541581; AID541582; AID541583
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Biological Processes (45)

Process	via Protein(s)	Taxonomy
cell surface receptor signaling pathway via JAK-STAT	Interferon beta	Homo sapiens (human)
response to exogenous dsRNA	Interferon beta	Homo sapiens (human)
B cell activation involved in immune response	Interferon beta	Homo sapiens (human)
cell surface receptor signaling pathway	Interferon beta	Homo sapiens (human)
cell surface receptor signaling pathway via JAK-STAT	Interferon beta	Homo sapiens (human)
response to virus	Interferon beta	Homo sapiens (human)
positive regulation of autophagy	Interferon beta	Homo sapiens (human)
cytokine-mediated signaling pathway	Interferon beta	Homo sapiens (human)
natural killer cell activation	Interferon beta	Homo sapiens (human)
positive regulation of peptidyl-serine phosphorylation of STAT protein	Interferon beta	Homo sapiens (human)
cellular response to interferon-beta	Interferon beta	Homo sapiens (human)
B cell proliferation	Interferon beta	Homo sapiens (human)
negative regulation of viral genome replication	Interferon beta	Homo sapiens (human)
innate immune response	Interferon beta	Homo sapiens (human)
positive regulation of innate immune response	Interferon beta	Homo sapiens (human)
regulation of MHC class I biosynthetic process	Interferon beta	Homo sapiens (human)
negative regulation of T cell differentiation	Interferon beta	Homo sapiens (human)
positive regulation of transcription by RNA polymerase II	Interferon beta	Homo sapiens (human)
defense response to virus	Interferon beta	Homo sapiens (human)
type I interferon-mediated signaling pathway	Interferon beta	Homo sapiens (human)
neuron cellular homeostasis	Interferon beta	Homo sapiens (human)
cellular response to exogenous dsRNA	Interferon beta	Homo sapiens (human)
cellular response to virus	Interferon beta	Homo sapiens (human)
negative regulation of Lewy body formation	Interferon beta	Homo sapiens (human)
negative regulation of T-helper 2 cell cytokine production	Interferon beta	Homo sapiens (human)
positive regulation of apoptotic signaling pathway	Interferon beta	Homo sapiens (human)
response to exogenous dsRNA	Interferon beta	Homo sapiens (human)
B cell differentiation	Interferon beta	Homo sapiens (human)
natural killer cell activation involved in immune response	Interferon beta	Homo sapiens (human)
adaptive immune response	Interferon beta	Homo sapiens (human)
T cell activation involved in immune response	Interferon beta	Homo sapiens (human)
humoral immune response	Interferon beta	Homo sapiens (human)
positive regulation of T cell mediated cytotoxicity	HLA class I histocompatibility antigen, B alpha chain	Homo sapiens (human)
adaptive immune response	HLA class I histocompatibility antigen, B alpha chain	Homo sapiens (human)
antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent	HLA class I histocompatibility antigen, B alpha chain	Homo sapiens (human)
regulation of T cell anergy	HLA class I histocompatibility antigen, B alpha chain	Homo sapiens (human)
defense response	HLA class I histocompatibility antigen, B alpha chain	Homo sapiens (human)
immune response	HLA class I histocompatibility antigen, B alpha chain	Homo sapiens (human)
detection of bacterium	HLA class I histocompatibility antigen, B alpha chain	Homo sapiens (human)
regulation of interleukin-12 production	HLA class I histocompatibility antigen, B alpha chain	Homo sapiens (human)
regulation of interleukin-6 production	HLA class I histocompatibility antigen, B alpha chain	Homo sapiens (human)
protection from natural killer cell mediated cytotoxicity	HLA class I histocompatibility antigen, B alpha chain	Homo sapiens (human)
innate immune response	HLA class I histocompatibility antigen, B alpha chain	Homo sapiens (human)
regulation of dendritic cell differentiation	HLA class I histocompatibility antigen, B alpha chain	Homo sapiens (human)
antigen processing and presentation of endogenous peptide antigen via MHC class Ib	HLA class I histocompatibility antigen, B alpha chain	Homo sapiens (human)
inositol phosphate metabolic process	Inositol hexakisphosphate kinase 1	Homo sapiens (human)
phosphatidylinositol phosphate biosynthetic process	Inositol hexakisphosphate kinase 1	Homo sapiens (human)
negative regulation of cold-induced thermogenesis	Inositol hexakisphosphate kinase 1	Homo sapiens (human)
inositol phosphate biosynthetic process	Inositol hexakisphosphate kinase 1	Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Molecular Functions (18)

Process	via Protein(s)	Taxonomy
cytokine activity	Interferon beta	Homo sapiens (human)
cytokine receptor binding	Interferon beta	Homo sapiens (human)
type I interferon receptor binding	Interferon beta	Homo sapiens (human)
protein binding	Interferon beta	Homo sapiens (human)
chloramphenicol O-acetyltransferase activity	Interferon beta	Homo sapiens (human)
TAP binding	HLA class I histocompatibility antigen, B alpha chain	Homo sapiens (human)
signaling receptor binding	HLA class I histocompatibility antigen, B alpha chain	Homo sapiens (human)
protein binding	HLA class I histocompatibility antigen, B alpha chain	Homo sapiens (human)
peptide antigen binding	HLA class I histocompatibility antigen, B alpha chain	Homo sapiens (human)
TAP binding	HLA class I histocompatibility antigen, B alpha chain	Homo sapiens (human)
protein-folding chaperone binding	HLA class I histocompatibility antigen, B alpha chain	Homo sapiens (human)
inositol-1,3,4,5,6-pentakisphosphate kinase activity	Inositol hexakisphosphate kinase 1	Homo sapiens (human)
inositol hexakisphosphate kinase activity	Inositol hexakisphosphate kinase 1	Homo sapiens (human)
inositol heptakisphosphate kinase activity	Inositol hexakisphosphate kinase 1	Homo sapiens (human)
inositol hexakisphosphate 5-kinase activity	Inositol hexakisphosphate kinase 1	Homo sapiens (human)
protein binding	Inositol hexakisphosphate kinase 1	Homo sapiens (human)
ATP binding	Inositol hexakisphosphate kinase 1	Homo sapiens (human)
inositol hexakisphosphate 1-kinase activity	Inositol hexakisphosphate kinase 1	Homo sapiens (human)
inositol hexakisphosphate 3-kinase activity	Inositol hexakisphosphate kinase 1	Homo sapiens (human)
inositol 5-diphosphate pentakisphosphate 5-kinase activity	Inositol hexakisphosphate kinase 1	Homo sapiens (human)
inositol diphosphate tetrakisphosphate kinase activity	Inositol hexakisphosphate kinase 1	Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Ceullar Components (22)

Process	via Protein(s)	Taxonomy
extracellular space	Interferon beta	Homo sapiens (human)
extracellular region	Interferon beta	Homo sapiens (human)
Golgi membrane	HLA class I histocompatibility antigen, B alpha chain	Homo sapiens (human)
endoplasmic reticulum	HLA class I histocompatibility antigen, B alpha chain	Homo sapiens (human)
Golgi apparatus	HLA class I histocompatibility antigen, B alpha chain	Homo sapiens (human)
plasma membrane	HLA class I histocompatibility antigen, B alpha chain	Homo sapiens (human)
cell surface	HLA class I histocompatibility antigen, B alpha chain	Homo sapiens (human)
ER to Golgi transport vesicle membrane	HLA class I histocompatibility antigen, B alpha chain	Homo sapiens (human)
membrane	HLA class I histocompatibility antigen, B alpha chain	Homo sapiens (human)
secretory granule membrane	HLA class I histocompatibility antigen, B alpha chain	Homo sapiens (human)
phagocytic vesicle membrane	HLA class I histocompatibility antigen, B alpha chain	Homo sapiens (human)
early endosome membrane	HLA class I histocompatibility antigen, B alpha chain	Homo sapiens (human)
recycling endosome membrane	HLA class I histocompatibility antigen, B alpha chain	Homo sapiens (human)
extracellular exosome	HLA class I histocompatibility antigen, B alpha chain	Homo sapiens (human)
lumenal side of endoplasmic reticulum membrane	HLA class I histocompatibility antigen, B alpha chain	Homo sapiens (human)
MHC class I protein complex	HLA class I histocompatibility antigen, B alpha chain	Homo sapiens (human)
extracellular space	HLA class I histocompatibility antigen, B alpha chain	Homo sapiens (human)
external side of plasma membrane	HLA class I histocompatibility antigen, B alpha chain	Homo sapiens (human)
fibrillar center	Inositol hexakisphosphate kinase 1	Homo sapiens (human)
nucleoplasm	Inositol hexakisphosphate kinase 1	Homo sapiens (human)
cytosol	Inositol hexakisphosphate kinase 1	Homo sapiens (human)
nucleus	Inositol hexakisphosphate kinase 1	Homo sapiens (human)
cytoplasm	Inositol hexakisphosphate kinase 1	Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Bioassays (129)

Assay ID	Title	Year	Journal	Article
AID541285	Activity of Staphylococcus aureus MetRS G223C mutant by ATP:PPi exchange assay in presence of ATP	2009	Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1	Inhibition of methionyl-tRNA synthetase by REP8839 and effects of resistance mutations on enzyme activity.
AID541265	Activity of Streptococcus pneumoniae MetRS1 by ATP:PPi exchange assay in presence of methionine	2009	Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1	Inhibition of methionyl-tRNA synthetase by REP8839 and effects of resistance mutations on enzyme activity.
AID541301	Activity of Staphylococcus aureus MetRS I57N, A247E mutant by ATP:PPi exchange assay in presence of methionine	2009	Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1	Inhibition of methionyl-tRNA synthetase by REP8839 and effects of resistance mutations on enzyme activity.
AID541291	Activity of Staphylococcus aureus MetRS I57N, G54S mutant by ATP:PPi exchange assay in presence of ATP	2009	Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1	Inhibition of methionyl-tRNA synthetase by REP8839 and effects of resistance mutations on enzyme activity.
AID541622	Ratio of Kcat to Km for Staphylococcus aureus MetRS G54S mutant in presence of tRNA	2009	Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1	Inhibition of methionyl-tRNA synthetase by REP8839 and effects of resistance mutations on enzyme activity.
AID541287	Activity of Staphylococcus aureus MetRS G54S mutant by ATP:PPi exchange assay in presence of ATP	2009	Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1	Inhibition of methionyl-tRNA synthetase by REP8839 and effects of resistance mutations on enzyme activity.
AID541279	Activity of Escherichia coli MetRS by ATP:PPi exchange assay in presence of ATP	2009	Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1	Inhibition of methionyl-tRNA synthetase by REP8839 and effects of resistance mutations on enzyme activity.
AID541306	Ratio of Kcat to Km for Staphylococcus aureus MetRS I57N mutant in presence of ATP	2009	Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1	Inhibition of methionyl-tRNA synthetase by REP8839 and effects of resistance mutations on enzyme activity.
AID541304	Ratio of Kcat to Km for Staphylococcus aureus MetRS L213W mutant in presence of ATP	2009	Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1	Inhibition of methionyl-tRNA synthetase by REP8839 and effects of resistance mutations on enzyme activity.
AID541624	Ratio of Kcat to Km for Staphylococcus aureus MetRS I57N I238F mutant in presence of tRNA	2009	Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1	Inhibition of methionyl-tRNA synthetase by REP8839 and effects of resistance mutations on enzyme activity.
AID541335	Ratio of Kcat to Km for Staphylococcus aureus MetRS in presence of methionine	2009	Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1	Inhibition of methionyl-tRNA synthetase by REP8839 and effects of resistance mutations on enzyme activity.
AID541314	Ratio of Kcat to Km for Staphylococcus aureus MetRS G54A A64P mutant in presence of ATP	2009	Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1	Inhibition of methionyl-tRNA synthetase by REP8839 and effects of resistance mutations on enzyme activity.
AID545010	Antimicrobial activity against Staphylococcus aureus expressing MetRS I57N I238F mutant	2009	Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1	Inhibition of methionyl-tRNA synthetase by REP8839 and effects of resistance mutations on enzyme activity.
AID541267	Antimicrobial activity against Staphylococcus aureus expressing MetRS G54A A64P mutant	2009	Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1	Inhibition of methionyl-tRNA synthetase by REP8839 and effects of resistance mutations on enzyme activity.
AID541299	Activity of Staphylococcus aureus MetRS I57N, V242F mutant by ATP:PPi exchange assay in presence of methionine	2009	Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1	Inhibition of methionyl-tRNA synthetase by REP8839 and effects of resistance mutations on enzyme activity.
AID541333	Ratio of Kcat to Km for Staphylococcus aureus MetRS G54A A64P mutant in presence of methionine	2009	Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1	Inhibition of methionyl-tRNA synthetase by REP8839 and effects of resistance mutations on enzyme activity.
AID541277	Activity of Haemophilus influenzae MetRS by ATP:PPi exchange assay in presence of ATP	2009	Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1	Inhibition of methionyl-tRNA synthetase by REP8839 and effects of resistance mutations on enzyme activity.
AID541578	Activity of streptococcus aureus MetRS G54S mutant by scintillation proximity assay in presence of tRNA	2009	Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1	Inhibition of methionyl-tRNA synthetase by REP8839 and effects of resistance mutations on enzyme activity.
AID541320	Inhibition of Staphylococcus aureus MetRS V108M mutant	2009	Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1	Inhibition of methionyl-tRNA synthetase by REP8839 and effects of resistance mutations on enzyme activity.
AID541581	Activity of streptococcus aureus MetRS I57N, A247E mutant by scintillation proximity assay in presence of tRNA	2009	Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1	Inhibition of methionyl-tRNA synthetase by REP8839 and effects of resistance mutations on enzyme activity.
AID541332	Ratio of Kcat to Km for Staphylococcus aureus MetRS I57N G54S mutant in presence of methionine	2009	Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1	Inhibition of methionyl-tRNA synthetase by REP8839 and effects of resistance mutations on enzyme activity.
AID541315	Ratio of Kcat to Km for Staphylococcus aureus MetRS L213W mutant in presence of methionine	2009	Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1	Inhibition of methionyl-tRNA synthetase by REP8839 and effects of resistance mutations on enzyme activity.
AID541288	Activity of Staphylococcus aureus MetRS I57N, V242F mutant by ATP:PPi exchange assay in presence of ATP	2009	Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1	Inhibition of methionyl-tRNA synthetase by REP8839 and effects of resistance mutations on enzyme activity.
AID541268	Inhibition of Staphylococcus aureus MetRS L213W mutant	2009	Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1	Inhibition of methionyl-tRNA synthetase by REP8839 and effects of resistance mutations on enzyme activity.
AID541324	Inhibition of Staphylococcus aureus MetRS I57N A247E mutant	2009	Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1	Inhibition of methionyl-tRNA synthetase by REP8839 and effects of resistance mutations on enzyme activity.
AID541553	Activity of streptococcus aureus MetRS V108M mutant by scintillation proximity assay in presence of tRNA	2009	Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1	Inhibition of methionyl-tRNA synthetase by REP8839 and effects of resistance mutations on enzyme activity.
AID541552	Activity of streptococcus aureus MetRS G223C mutant by scintillation proximity assay in presence of tRNA	2009	Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1	Inhibition of methionyl-tRNA synthetase by REP8839 and effects of resistance mutations on enzyme activity.
AID541271	Activity of human mitochondrial MetRS by ATP:PPi exchange assay in presence of methionine	2009	Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1	Inhibition of methionyl-tRNA synthetase by REP8839 and effects of resistance mutations on enzyme activity.
AID541302	Activity of Staphylococcus aureus MetRS I57N, G54S mutant by ATP:PPi exchange assay in presence of methionine	2009	Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1	Inhibition of methionyl-tRNA synthetase by REP8839 and effects of resistance mutations on enzyme activity.
AID541623	Ratio of Kcat to Km for Staphylococcus aureus MetRS I57N V242F mutant in presence of tRNA	2009	Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1	Inhibition of methionyl-tRNA synthetase by REP8839 and effects of resistance mutations on enzyme activity.
AID541579	Activity of streptococcus aureus MetRS I57N, V242F mutant by scintillation proximity assay in presence of tRNA	2009	Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1	Inhibition of methionyl-tRNA synthetase by REP8839 and effects of resistance mutations on enzyme activity.
AID541278	Activity of human mitochondrial MetRS by ATP:PPi exchange assay in presence of ATP	2009	Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1	Inhibition of methionyl-tRNA synthetase by REP8839 and effects of resistance mutations on enzyme activity.
AID545008	Antimicrobial activity against Staphylococcus aureus expressing MetRS G54S mutant	2009	Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1	Inhibition of methionyl-tRNA synthetase by REP8839 and effects of resistance mutations on enzyme activity.
AID541319	Inhibition of Staphylococcus aureus MetRS G223C mutant	2009	Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1	Inhibition of methionyl-tRNA synthetase by REP8839 and effects of resistance mutations on enzyme activity.
AID541321	Inhibition of Staphylococcus aureus MetRS G54S mutant	2009	Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1	Inhibition of methionyl-tRNA synthetase by REP8839 and effects of resistance mutations on enzyme activity.
AID541582	Activity of streptococcus aureus MetRS I57N, G54S mutant by scintillation proximity assay in presence of tRNA	2009	Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1	Inhibition of methionyl-tRNA synthetase by REP8839 and effects of resistance mutations on enzyme activity.
AID541270	Activity of Haemophilus influenzae MetRS by ATP:PPi exchange assay in presence of methionine	2009	Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1	Inhibition of methionyl-tRNA synthetase by REP8839 and effects of resistance mutations on enzyme activity.
AID541283	Activity of Staphylococcus aureus MetRS A247E mutant by ATP:PPi exchange assay in presence of ATP	2009	Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1	Inhibition of methionyl-tRNA synthetase by REP8839 and effects of resistance mutations on enzyme activity.
AID544993	Antimicrobial activity against Escherichia coli expressing MetRS gene	2009	Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1	Inhibition of methionyl-tRNA synthetase by REP8839 and effects of resistance mutations on enzyme activity.
AID541309	Ratio of Kcat to Km for Staphylococcus aureus MetRS G54S mutant in presence of ATP	2009	Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1	Inhibition of methionyl-tRNA synthetase by REP8839 and effects of resistance mutations on enzyme activity.
AID541322	Inhibition of Staphylococcus aureus MetRS I57N V242F mutant	2009	Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1	Inhibition of methionyl-tRNA synthetase by REP8839 and effects of resistance mutations on enzyme activity.
AID541330	Ratio of Kcat to Km for Staphylococcus aureus MetRS I57N I238F mutant in presence of methionine	2009	Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1	Inhibition of methionyl-tRNA synthetase by REP8839 and effects of resistance mutations on enzyme activity.
AID541585	Ratio of Kcat to Km for Staphylococcus aureus MetRS A247E mutant in presence of tRNA	2009	Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1	Inhibition of methionyl-tRNA synthetase by REP8839 and effects of resistance mutations on enzyme activity.
AID541625	Ratio of Kcat to Km for Staphylococcus aureus MetRS I57N A247E mutant in presence of tRNA	2009	Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1	Inhibition of methionyl-tRNA synthetase by REP8839 and effects of resistance mutations on enzyme activity.
AID541621	Ratio of Kcat to Km for Staphylococcus aureus MetRS V108M mutant in presence of tRNA	2009	Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1	Inhibition of methionyl-tRNA synthetase by REP8839 and effects of resistance mutations on enzyme activity.
AID541311	Ratio of Kcat to Km for Staphylococcus aureus MetRS I57N I238F mutant in presence of ATP	2009	Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1	Inhibition of methionyl-tRNA synthetase by REP8839 and effects of resistance mutations on enzyme activity.
AID541310	Ratio of Kcat to Km for Staphylococcus aureus MetRS I57N V242F mutant in presence of ATP	2009	Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1	Inhibition of methionyl-tRNA synthetase by REP8839 and effects of resistance mutations on enzyme activity.
AID544997	Inhibition of Streptococcus pneumoniae MetRS1	2009	Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1	Inhibition of methionyl-tRNA synthetase by REP8839 and effects of resistance mutations on enzyme activity.
AID541337	Inhibition of Staphylococcus aureus MetRS G54A A64P mutant	2009	Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1	Inhibition of methionyl-tRNA synthetase by REP8839 and effects of resistance mutations on enzyme activity.
AID545004	Antimicrobial activity against Staphylococcus aureus expressing MetRS A247E mutant	2009	Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1	Inhibition of methionyl-tRNA synthetase by REP8839 and effects of resistance mutations on enzyme activity.
AID541316	Ratio of Kcat to Km for Staphylococcus aureus MetRS A247E mutant in presence of methionine	2009	Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1	Inhibition of methionyl-tRNA synthetase by REP8839 and effects of resistance mutations on enzyme activity.
AID545003	Antimicrobial activity against Staphylococcus aureus expressing MetRS L213W mutant	2009	Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1	Inhibition of methionyl-tRNA synthetase by REP8839 and effects of resistance mutations on enzyme activity.
AID541619	Ratio of Kcat to Km for Staphylococcus aureus MetRS I57N mutant in presence of tRNA	2009	Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1	Inhibition of methionyl-tRNA synthetase by REP8839 and effects of resistance mutations on enzyme activity.
AID541286	Activity of Staphylococcus aureus MetRS V108M mutant by ATP:PPi exchange assay in presence of ATP	2009	Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1	Inhibition of methionyl-tRNA synthetase by REP8839 and effects of resistance mutations on enzyme activity.
AID541272	Activity of Escherichia coli MetRS by ATP:PPi exchange assay in presence of methionine	2009	Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1	Inhibition of methionyl-tRNA synthetase by REP8839 and effects of resistance mutations on enzyme activity.
AID541318	Inhibition of Staphylococcus aureus MetRS I57N mutant	2009	Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1	Inhibition of methionyl-tRNA synthetase by REP8839 and effects of resistance mutations on enzyme activity.
AID541558	Cytotoxicity against rat H42E cells by MTT assay	2009	Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1	Inhibition of methionyl-tRNA synthetase by REP8839 and effects of resistance mutations on enzyme activity.
AID541325	Inhibition of Staphylococcus aureus MetRS I57N G54S mutant	2009	Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1	Inhibition of methionyl-tRNA synthetase by REP8839 and effects of resistance mutations on enzyme activity.
AID541557	Cytotoxicity against human A549 cells by MTT assay	2009	Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1	Inhibition of methionyl-tRNA synthetase by REP8839 and effects of resistance mutations on enzyme activity.
AID541276	Activity of Streptococcus pneumoniae MetRS1 by ATP:PPi exchange assay in presence of ATP	2009	Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1	Inhibition of methionyl-tRNA synthetase by REP8839 and effects of resistance mutations on enzyme activity.
AID544999	Inhibition of human mitochondrial MetRS	2009	Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1	Inhibition of methionyl-tRNA synthetase by REP8839 and effects of resistance mutations on enzyme activity.
AID541556	Ratio of Kcat to Km for Staphylococcus aureus MetRS in presence of tRNA	2009	Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1	Inhibition of methionyl-tRNA synthetase by REP8839 and effects of resistance mutations on enzyme activity.
AID541289	Activity of Staphylococcus aureus MetRS I57N, I238F mutant by ATP:PPi exchange assay in presence of ATP	2009	Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1	Inhibition of methionyl-tRNA synthetase by REP8839 and effects of resistance mutations on enzyme activity.
AID541280	Activity of Thermus thermophilus HB8 MetRS by ATP:PPi exchange assay in presence of ATP	2009	Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1	Inhibition of methionyl-tRNA synthetase by REP8839 and effects of resistance mutations on enzyme activity.
AID541292	Activity of Staphylococcus aureus MetRS G54A, A64P mutant by ATP:PPi exchange assay in presence of ATP	2009	Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1	Inhibition of methionyl-tRNA synthetase by REP8839 and effects of resistance mutations on enzyme activity.
AID541551	Activity of streptococcus aureus MetRS I57N mutant by scintillation proximity assay in presence of tRNA	2009	Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1	Inhibition of methionyl-tRNA synthetase by REP8839 and effects of resistance mutations on enzyme activity.
AID541298	Activity of Staphylococcus aureus MetRS G54S mutant by ATP:PPi exchange assay in presence of methionine	2009	Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1	Inhibition of methionyl-tRNA synthetase by REP8839 and effects of resistance mutations on enzyme activity.
AID629749	Antibacterial activity against mupirocin or oxacillin-resistant Staphylococcus aureus	2011	European journal of medicinal chemistry, Nov, Volume: 46, Issue:11	Aminoacyl-tRNA synthetase inhibitors as potential antibiotics.
AID541554	Ratio of Kcat to Km for Staphylococcus aureus MetRS G54A A64P mutant in presence of tRNA	2009	Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1	Inhibition of methionyl-tRNA synthetase by REP8839 and effects of resistance mutations on enzyme activity.
AID541264	Activity of Staphylococcus aureus MetRS by ATP:PPi exchange assay in presence of methionine	2009	Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1	Inhibition of methionyl-tRNA synthetase by REP8839 and effects of resistance mutations on enzyme activity.
AID541300	Activity of Staphylococcus aureus MetRS I57N, I238F mutant by ATP:PPi exchange assay in presence of methionine	2009	Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1	Inhibition of methionyl-tRNA synthetase by REP8839 and effects of resistance mutations on enzyme activity.
AID541555	Activity of streptococcus aureus by scintillation proximity assay in presence of tRNA	2009	Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1	Inhibition of methionyl-tRNA synthetase by REP8839 and effects of resistance mutations on enzyme activity.
AID541336	Activity of streptococcus aureus MetRS L213W mutant by scintillation proximity assay in presence of tRNA	2009	Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1	Inhibition of methionyl-tRNA synthetase by REP8839 and effects of resistance mutations on enzyme activity.
AID545000	Inhibition of Haemophilus influenzae MetRS	2009	Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1	Inhibition of methionyl-tRNA synthetase by REP8839 and effects of resistance mutations on enzyme activity.
AID541583	Activity of streptococcus aureus MetRS G54A, A64P mutant by scintillation proximity assay in presence of tRNA	2009	Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1	Inhibition of methionyl-tRNA synthetase by REP8839 and effects of resistance mutations on enzyme activity.
AID545005	Antimicrobial activity against Staphylococcus aureus expressing MetRS I57N mutant	2009	Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1	Inhibition of methionyl-tRNA synthetase by REP8839 and effects of resistance mutations on enzyme activity.
AID541303	Activity of Staphylococcus aureus MetRS G54A, A64P mutant by ATP:PPi exchange assay in presence of methionine	2009	Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1	Inhibition of methionyl-tRNA synthetase by REP8839 and effects of resistance mutations on enzyme activity.
AID544996	Inhibition of Staphylococcus aureus MetRS	2009	Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1	Inhibition of methionyl-tRNA synthetase by REP8839 and effects of resistance mutations on enzyme activity.
AID544995	Antimicrobial activity against Streptococcus pneumoniae expressing MetRS2 gene	2009	Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1	Inhibition of methionyl-tRNA synthetase by REP8839 and effects of resistance mutations on enzyme activity.
AID541580	Activity of streptococcus aureus MetRS I57N, I238F mutant by scintillation proximity assay in presence of tRNA	2009	Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1	Inhibition of methionyl-tRNA synthetase by REP8839 and effects of resistance mutations on enzyme activity.
AID541550	Activity of streptococcus aureus MetRS A247E mutant by scintillation proximity assay in presence of tRNA	2009	Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1	Inhibition of methionyl-tRNA synthetase by REP8839 and effects of resistance mutations on enzyme activity.
AID545006	Antimicrobial activity against Staphylococcus aureus expressing MetRS G223C mutant	2009	Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1	Inhibition of methionyl-tRNA synthetase by REP8839 and effects of resistance mutations on enzyme activity.
AID541294	Activity of Staphylococcus aureus MetRS A247E mutant by ATP:PPi exchange assay in presence of methionine	2009	Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1	Inhibition of methionyl-tRNA synthetase by REP8839 and effects of resistance mutations on enzyme activity.
AID544992	Antimicrobial activity against Streptococcus pneumoniae expressing MetRS1 gene	2009	Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1	Inhibition of methionyl-tRNA synthetase by REP8839 and effects of resistance mutations on enzyme activity.
AID541290	Activity of Staphylococcus aureus MetRS I57N, A247E mutant by ATP:PPi exchange assay in presence of ATP	2009	Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1	Inhibition of methionyl-tRNA synthetase by REP8839 and effects of resistance mutations on enzyme activity.
AID545009	Antimicrobial activity against Staphylococcus aureus expressing MetRS I57N V242F mutant	2009	Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1	Inhibition of methionyl-tRNA synthetase by REP8839 and effects of resistance mutations on enzyme activity.
AID541295	Activity of Staphylococcus aureus MetRS I57N mutant by ATP:PPi exchange assay in presence of methionine	2009	Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1	Inhibition of methionyl-tRNA synthetase by REP8839 and effects of resistance mutations on enzyme activity.
AID541273	Activity of Thermus thermophilus HB8 MetRS by ATP:PPi exchange assay in presence of methionine	2009	Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1	Inhibition of methionyl-tRNA synthetase by REP8839 and effects of resistance mutations on enzyme activity.
AID541326	Ratio of Kcat to Km for Staphylococcus aureus MetRS G223C mutant in presence of methionine	2009	Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1	Inhibition of methionyl-tRNA synthetase by REP8839 and effects of resistance mutations on enzyme activity.
AID541296	Activity of Staphylococcus aureus MetRS G223C mutant by ATP:PPi exchange assay in presence of methionine	2009	Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1	Inhibition of methionyl-tRNA synthetase by REP8839 and effects of resistance mutations on enzyme activity.
AID541281	Activity of Bacillus stearothermophilus MetRS by ATP:PPi exchange assay in presence of ATP	2009	Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1	Inhibition of methionyl-tRNA synthetase by REP8839 and effects of resistance mutations on enzyme activity.
AID545001	Inhibition of Streptococcus pneumoniae MetRS2	2009	Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1	Inhibition of methionyl-tRNA synthetase by REP8839 and effects of resistance mutations on enzyme activity.
AID541275	Activity of Staphylococcus aureus MetRS by ATP:PPi exchange assay in presence of ATP	2009	Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1	Inhibition of methionyl-tRNA synthetase by REP8839 and effects of resistance mutations on enzyme activity.
AID541584	Ratio of Kcat to Km for Staphylococcus aureus MetRS L213W mutant in presence of tRNA	2009	Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1	Inhibition of methionyl-tRNA synthetase by REP8839 and effects of resistance mutations on enzyme activity.
AID541269	Inhibition of Staphylococcus aureus MetRS A247E mutant	2009	Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1	Inhibition of methionyl-tRNA synthetase by REP8839 and effects of resistance mutations on enzyme activity.
AID541334	Ratio of Kcat to Km for Staphylococcus aureus MetRS in presence of ATP	2009	Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1	Inhibition of methionyl-tRNA synthetase by REP8839 and effects of resistance mutations on enzyme activity.
AID541312	Ratio of Kcat to Km for Staphylococcus aureus MetRS I57N A247E mutant in presence of ATP	2009	Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1	Inhibition of methionyl-tRNA synthetase by REP8839 and effects of resistance mutations on enzyme activity.
AID541305	Ratio of Kcat to Km for Staphylococcus aureus MetRS A247E mutant in presence of ATP	2009	Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1	Inhibition of methionyl-tRNA synthetase by REP8839 and effects of resistance mutations on enzyme activity.
AID544994	Antimicrobial activity against Haemophilus influenzae expressing MetRS gene	2009	Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1	Inhibition of methionyl-tRNA synthetase by REP8839 and effects of resistance mutations on enzyme activity.
AID541307	Ratio of Kcat to Km for Staphylococcus aureus MetRS G223C mutant in presence of ATP	2009	Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1	Inhibition of methionyl-tRNA synthetase by REP8839 and effects of resistance mutations on enzyme activity.
AID541266	Antimicrobial activity against Staphylococcus aureus expressing MetRS I57N G54S mutant	2009	Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1	Inhibition of methionyl-tRNA synthetase by REP8839 and effects of resistance mutations on enzyme activity.
AID541282	Activity of Staphylococcus aureus MetRS L213W mutant by ATP:PPi exchange assay in presence of ATP	2009	Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1	Inhibition of methionyl-tRNA synthetase by REP8839 and effects of resistance mutations on enzyme activity.
AID541329	Ratio of Kcat to Km for Staphylococcus aureus MetRS I57N V242F mutant in presence of methionine	2009	Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1	Inhibition of methionyl-tRNA synthetase by REP8839 and effects of resistance mutations on enzyme activity.
AID541620	Ratio of Kcat to Km for Staphylococcus aureus MetRS G223C mutant in presence of tRNA	2009	Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1	Inhibition of methionyl-tRNA synthetase by REP8839 and effects of resistance mutations on enzyme activity.
AID541284	Activity of Staphylococcus aureus MetRS I57N mutant by ATP:PPi exchange assay in presence of ATP	2009	Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1	Inhibition of methionyl-tRNA synthetase by REP8839 and effects of resistance mutations on enzyme activity.
AID544998	Inhibition of Escherichia coli MetRS	2009	Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1	Inhibition of methionyl-tRNA synthetase by REP8839 and effects of resistance mutations on enzyme activity.
AID541293	Activity of Staphylococcus aureus MetRS L213W mutant by ATP:PPi exchange assay in presence of methionine	2009	Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1	Inhibition of methionyl-tRNA synthetase by REP8839 and effects of resistance mutations on enzyme activity.
AID545002	Inhibition of human cytoplasmic MetRS	2009	Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1	Inhibition of methionyl-tRNA synthetase by REP8839 and effects of resistance mutations on enzyme activity.
AID541317	Ratio of Kcat to Km for Staphylococcus aureus MetRS I57N mutant in presence of methionine	2009	Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1	Inhibition of methionyl-tRNA synthetase by REP8839 and effects of resistance mutations on enzyme activity.
AID541308	Ratio of Kcat to Km for Staphylococcus aureus MetRS V108M mutant in presence of ATP	2009	Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1	Inhibition of methionyl-tRNA synthetase by REP8839 and effects of resistance mutations on enzyme activity.
AID541328	Ratio of Kcat to Km for Staphylococcus aureus MetRS G54S mutant in presence of methionine	2009	Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1	Inhibition of methionyl-tRNA synthetase by REP8839 and effects of resistance mutations on enzyme activity.
AID629750	Antibacterial activity against Streptococcus pyogenes	2011	European journal of medicinal chemistry, Nov, Volume: 46, Issue:11	Aminoacyl-tRNA synthetase inhibitors as potential antibiotics.
AID541331	Ratio of Kcat to Km for Staphylococcus aureus MetRS I57N A247E mutant in presence of methionine	2009	Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1	Inhibition of methionyl-tRNA synthetase by REP8839 and effects of resistance mutations on enzyme activity.
AID541297	Activity of Staphylococcus aureus MetRS V108M mutant by ATP:PPi exchange assay in presence of methionine	2009	Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1	Inhibition of methionyl-tRNA synthetase by REP8839 and effects of resistance mutations on enzyme activity.
AID541313	Ratio of Kcat to Km for Staphylococcus aureus MetRS I57N G54S mutant in presence of ATP	2009	Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1	Inhibition of methionyl-tRNA synthetase by REP8839 and effects of resistance mutations on enzyme activity.
AID541626	Ratio of Kcat to Km for Staphylococcus aureus MetRS I57N G54S mutant in presence of tRNA	2009	Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1	Inhibition of methionyl-tRNA synthetase by REP8839 and effects of resistance mutations on enzyme activity.
AID544991	Antimicrobial activity against Staphylococcus aureus expressing MetRS gene	2009	Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1	Inhibition of methionyl-tRNA synthetase by REP8839 and effects of resistance mutations on enzyme activity.
AID541274	Activity of Bacillus stearothermophilus MetRS by ATP:PPi exchange assay in presence of methionine	2009	Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1	Inhibition of methionyl-tRNA synthetase by REP8839 and effects of resistance mutations on enzyme activity.
AID629751	Inhibition of Escherichia coli Methionyl-tRNA synthetase	2011	European journal of medicinal chemistry, Nov, Volume: 46, Issue:11	Aminoacyl-tRNA synthetase inhibitors as potential antibiotics.
AID545011	Antimicrobial activity against Staphylococcus aureus expressing MetRS I57N A247E mutant	2009	Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1	Inhibition of methionyl-tRNA synthetase by REP8839 and effects of resistance mutations on enzyme activity.
AID541323	Inhibition of Staphylococcus aureus MetRS I57N I238F mutant	2009	Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1	Inhibition of methionyl-tRNA synthetase by REP8839 and effects of resistance mutations on enzyme activity.
AID545007	Antimicrobial activity against Staphylococcus aureus expressing MetRS V108M mutant	2009	Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1	Inhibition of methionyl-tRNA synthetase by REP8839 and effects of resistance mutations on enzyme activity.
AID631124	Inhibition of Staphylococcus aureus Methionyl-tRNA synthetase	2011	European journal of medicinal chemistry, Nov, Volume: 46, Issue:11	Aminoacyl-tRNA synthetase inhibitors as potential antibiotics.
AID541327	Ratio of Kcat to Km for Staphylococcus aureus MetRS V108M mutant in presence of methionine	2009	Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1	Inhibition of methionyl-tRNA synthetase by REP8839 and effects of resistance mutations on enzyme activity.
AID1347159	Primary screen GU Rhodamine qHTS for Zika virus inhibitors: Unlinked NS2B-NS3 protease assay	2020	Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49	Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors.
AID1296008	Cytotoxic Profiling of Annotated Libraries Using Quantitative High-Throughput Screening	2020	SLAS discovery : advancing life sciences R & D, 01, Volume: 25, Issue:1	Cytotoxic Profiling of Annotated and Diverse Chemical Libraries Using Quantitative High-Throughput Screening.
AID1346986	P-glycoprotein substrates identified in KB-3-1 adenocarcinoma cell line, qHTS therapeutic library screen	2019	Molecular pharmacology, 11, Volume: 96, Issue:5	A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein.
AID1347160	Primary screen NINDS Rhodamine qHTS for Zika virus inhibitors	2020	Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49	Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors.
AID1346987	P-glycoprotein substrates identified in KB-8-5-11 adenocarcinoma cell line, qHTS therapeutic library screen	2019	Molecular pharmacology, 11, Volume: 96, Issue:5	A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (9)

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	3 (33.33)	29.6817
2010's	4 (44.44)	24.3611
2020's	2 (22.22)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.43

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

Metric	This Compound (vs All)
Research Demand Index	12.43 (24.57)
Research Supply Index	2.30 (2.92)
Research Growth Index	4.73 (4.65)
Search Engine Demand Index	0.00 (26.88)
Search Engine Supply Index	0.00 (0.95)

This Compound (12.43)

All Compounds (24.57)

Study Types

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	2 (22.22%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	7 (77.78%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
methionine Methionine: A sulfur-containing essential L-amino acid that is important in many body functions.. methionine : A sulfur-containing amino acid that is butyric acid bearing an amino substituent at position 2 and a methylthio substituent at position 4.	2.05	1	aspartate family amino acid; L-alpha-amino acid; methionine zwitterion; methionine; proteinogenic amino acid	antidote to paracetamol poisoning; human metabolite; micronutrient; mouse metabolite; nutraceutical
thiophenes Thiophenes: A monocyclic heteroarene furan in which the oxygen atom is replaced by a sulfur.. thiophenes : Compounds containing at least one thiophene ring.	4.26	5	mancude organic heteromonocyclic parent; monocyclic heteroarene; thiophenes; volatile organic compound	non-polar solvent
mupirocin Mupirocin: A topically used antibiotic from a strain of Pseudomonas fluorescens. It has shown excellent activity against gram-positive staphylococci and streptococci. The antibiotic is used primarily for the treatment of primary and secondary skin disorders, nasal infections, and wound healing.. mupirocin : An alpha,beta-unsaturated ester resulting from the formal condensation of the alcoholic hydroxy group of 9-hydroxynonanoic acid with the carboxy group of (2E)-4-[(2S)-tetrahydro-2H-pyran-2-yl]-3-methylbut-2-enoic acid in which the tetrahydropyranyl ring is substituted at positions 3 and 4 by hydroxy groups and at position 5 by a {(2S,3S)-3-[(2S,3S)-3-hydroxybutan-2-yl]oxiran-2-yl}methyl group. Originally isolated from the Gram-negative bacterium Pseudomonas fluorescens, it is used as a topical antibiotic for the treatment of Gram-positive bacterial infections.	3.86	3	alpha,beta-unsaturated carboxylic ester; epoxide; monocarboxylic acid; oxanes; secondary alcohol; triol	antibacterial drug; bacterial metabolite; protein synthesis inhibitor
rep 3123 REP 3123: structure in first source	2.11	1

Condition	Relationship Strength	Studies
Congenital Zika Syndrome [description not available]	2.25	1
Disease Models, Animal Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.	2.25	1
Zika Virus Infection A viral disease transmitted by the bite of AEDES mosquitoes infected with ZIKA VIRUS. Its mild DENGUE-like symptoms include fever, rash, headaches and ARTHRALGIA. The viral infection during pregnancy, in rare cases, is associated with congenital brain and ocular abnormalities, called Congenital Zika Syndrome, including MICROCEPHALY and may also lead to GUILLAIN-BARRE SYNDROME.	2.25	1
Anasarca [description not available]	2.05	1
Edema Abnormal fluid accumulation in TISSUES or body cavities. Most cases of edema are present under the SKIN in SUBCUTANEOUS TISSUE.	2.05	1
Erythema Redness of the skin produced by congestion of the capillaries. This condition may result from a variety of disease processes.	2.05	1

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