pawhuskin A: geranyl stilbene from Dalea purpurea; structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
| Flora | Rank | Flora Definition | Family | Family Definition |
|---|---|---|---|---|
| Dalea | genus | [no description available] | Fabaceae | The large family of plants characterized by pods. Some are edible and some cause LATHYRISM or FAVISM and other forms of poisoning. Other species yield useful materials like gums from ACACIA and various LECTINS like PHYTOHEMAGGLUTININS from PHASEOLUS. Many of them harbor NITROGEN FIXATION bacteria on their roots. Many but not all species of beans belong to this family.[MeSH] |
| ID Source | ID |
|---|---|
| PubMed CID | 10366422 |
| CHEMBL ID | 513748 |
| SCHEMBL ID | 18730144 |
| MeSH ID | M0463106 |
| Synonym |
|---|
| pawhuskin a |
| CHEMBL513748 |
| SCHEMBL18730144 |
| Q19598444 |
| 4-[(e)-2-[2-[(2e)-3,7-dimethylocta-2,6-dienyl]-3,5-dihydroxyphenyl]ethenyl]-3-(3-methylbut-2-enyl)benzene-1,2-diol |
| DTXSID001032044 |
Pawhuskin A is an isoprenylated stilbene. It was isolated from Dalea purpurea and reported to have affinity for the opioid receptor in vitro.
| Excerpt | Reference | Relevance |
|---|---|---|
| "Pawhuskin A is a prenylated stilbene that functions as an antagonist of the kappa opioid receptor. " | ( Selective Prenylation of Protected Phenols for Synthesis of Pawhuskin A Analogues. Gardner, KD; Wiemer, DF, 2016) | 2.12 |
| "Pawhuskin A is an isoprenylated stilbene that was isolated from Dalea purpurea and reported to have affinity for the opioid receptor in vitro. " | ( A concise synthesis of pawhuskin A. Boss, KD; Buller, MJ; Neighbors, JD; Wiemer, DF, 2008) | 2.1 |
| Protein | Taxonomy | Measurement | Average | Min (ref.) | Avg (ref.) | Max (ref.) | Bioassay(s) |
|---|---|---|---|---|---|---|---|
| Mu-type opioid receptor | Homo sapiens (human) | Ke | 0.5700 | 0.0000 | 0.2488 | 3.0700 | AID1066565 |
| Delta-type opioid receptor | Homo sapiens (human) | Ke | 2.9000 | 0.0001 | 0.6979 | 9.0700 | AID1066566 |
| Kappa-type opioid receptor | Homo sapiens (human) | Ke | 0.2000 | 0.0000 | 0.3540 | 5.8100 | AID1066567 |
| [prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023] | |||||||
| Assay ID | Title | Year | Journal | Article |
|---|---|---|---|---|
| AID1066565 | Competitive antagonist activity against human Mu opioid receptor overexpressed in CHO cells assessed as inhibition of DAMGO-stimulated [35S]GTP-gamma-S binding by liquid scintillation counting | 2014 | Journal of natural products, Feb-28, Volume: 77, Issue:2 | Stilbenes as κ-selective, non-nitrogenous opioid receptor antagonists. |
| AID1066566 | Competitive antagonist activity against human delta opioid receptor overexpressed in CHO cells assessed as inhibition of DPDPE-stimulated [35S]GTP-gamma-S binding by liquid scintillation counting | 2014 | Journal of natural products, Feb-28, Volume: 77, Issue:2 | Stilbenes as κ-selective, non-nitrogenous opioid receptor antagonists. |
| AID1066567 | Competitive antagonist activity against human kappa opioid receptor overexpressed in CHO cells assessed as inhibition of U69,593-stimulated [35S]GTP-gamma-S binding by liquid scintillation counting | 2014 | Journal of natural products, Feb-28, Volume: 77, Issue:2 | Stilbenes as κ-selective, non-nitrogenous opioid receptor antagonists. |
| AID1066564 | Selectivity ratio of Ke(app) for human delta opioid receptor to ratio of Ke(app) for human kappa opioid receptor | 2014 | Journal of natural products, Feb-28, Volume: 77, Issue:2 | Stilbenes as κ-selective, non-nitrogenous opioid receptor antagonists. |
| AID399187 | Displacement of [3H]naloxone from opioid receptor in Sprague-Dawley rat striatal membrane by scintillation spectrophotometry | 2004 | Journal of natural products, Jan, Volume: 67, Issue:1 | New geranyl stilbenes from Dalea purpurea with in vitro opioid receptor affinity. |
| AID1066563 | Selectivity ratio of Ke(app) for human Mu opioid receptor to ratio of Ke(app) for human kappa opioid receptor | 2014 | Journal of natural products, Feb-28, Volume: 77, Issue:2 | Stilbenes as κ-selective, non-nitrogenous opioid receptor antagonists. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||||
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (40.00) | 29.6817 |
| 2010's | 3 (60.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.
| This Compound (20.47) All Compounds (24.57) |
| Publication Type | This drug (%) | All Drugs (%) |
|---|---|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 0 (0.00%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 5 (100.00%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||