| Assay ID | Title | Year | Journal | Article |
|---|
| AID98834 | Fraction of the cell population of cultured lymphoid leukemia L1210 cells in mitosis after 12 hr; at the concentration of 0.03 uM | 1983 | Journal of medicinal chemistry, Jan, Volume: 26, Issue:1
| 1,2-Dihydropyrido[3,4-b]pyrazines: structure-activity relationships. |
| AID98511 | Cytotoxicity against lymphoid leukemia L1210 cells | 1991 | Journal of medicinal chemistry, Nov, Volume: 34, Issue:11
| Antimitotic agents. Alterations at the 2,3-positions of ethyl (5-amino-1,2-dihydropyrido[3,4-b]pyrazin-7-yl)carbamates. |
| AID96601 | Mitotic index (fraction of cells in mitosis divided by total cells) in cultured lymphoid leukemia L1210 cells | 1989 | Journal of medicinal chemistry, Sep, Volume: 32, Issue:9
| New anticancer agents: chiral isomers of ethyl 5-amino-1,2-dihydro-2-methyl-3-phenylpyrido[3,4-b]pyrazine-7-car bamate . |
| AID154001 | antitumor activity against lymphocyte leukemia P388 in mice as percentage of increase in life span for 1-5 days schedule (values in the parenthesen indicates dose) | 1983 | Journal of medicinal chemistry, Jan, Volume: 26, Issue:1
| 1,2-Dihydropyrido[3,4-b]pyrazines: structure-activity relationships. |
| AID98515 | The compound was tested in vitro for cytotoxicity against proliferation of cultured lymphoid leukemia L1210 cells | 1992 | Journal of medicinal chemistry, Mar-20, Volume: 35, Issue:6
| Antimitotic agents. Chiral isomers of ethyl [5-amino-1,2-dihydro-3-(4-hydroxyphenyl)-2-methylpyrido[3,4-b]pyrazin-7 -yl]carbamate. |
| AID96602 | Antimitotic activity against lymphoid leukemia L1210 cells. | 1991 | Journal of medicinal chemistry, Nov, Volume: 34, Issue:11
| Antimitotic agents. Alterations at the 2,3-positions of ethyl (5-amino-1,2-dihydropyrido[3,4-b]pyrazin-7-yl)carbamates. |
| AID96951 | inhibition of proliferation of cultured lymphoid leukemia L1210 cells during 48 hr. | 1983 | Journal of medicinal chemistry, Jan, Volume: 26, Issue:1
| 1,2-Dihydropyrido[3,4-b]pyrazines: structure-activity relationships. |
| AID98163 | Concentration that inhibits proliferation of cultured lymphoid leukemia L1210 cells to 50% control growth during 48 h | 1992 | Journal of medicinal chemistry, Dec-25, Volume: 35, Issue:26
| Antimitotic agents: ring analogues and derivatives of ethyl [(S)-5-amino-1,2-dihydro-2-methyl-3-phenylpyrido[3,4-b]pyrazin-7- yl]carbamate. |
| AID153998 | antitumor activity against lymphocyte leukemia P388 in mice as percentage of increase in life span for 1 day schedule | 1983 | Journal of medicinal chemistry, Jan, Volume: 26, Issue:1
| 1,2-Dihydropyrido[3,4-b]pyrazines: structure-activity relationships. |
| AID115195 | Increase in the life span(ILS) of mice. | 1991 | Journal of medicinal chemistry, Nov, Volume: 34, Issue:11
| Antimitotic agents. Alterations at the 2,3-positions of ethyl (5-amino-1,2-dihydropyrido[3,4-b]pyrazin-7-yl)carbamates. |
| AID152555 | Antitumor activity in mice implanted with lymphocytic P388 cells after intraperitoneal administration. | 1991 | Journal of medicinal chemistry, Nov, Volume: 34, Issue:11
| Antimitotic agents. Alterations at the 2,3-positions of ethyl (5-amino-1,2-dihydropyrido[3,4-b]pyrazin-7-yl)carbamates. |
| AID154910 | Increase in the life span of mice with P388 leukemia after the administration of the highest non toxic dose (1 mg/kg) | 1989 | Journal of medicinal chemistry, Sep, Volume: 32, Issue:9
| New anticancer agents: chiral isomers of ethyl 5-amino-1,2-dihydro-2-methyl-3-phenylpyrido[3,4-b]pyrazine-7-car bamate . |
| AID96598 | Concentration that causes a mitotic index (number of cells in mitosis divided by total cells) of 0.5 for cultured lymphoid leukemia L1210 cells during an exposure period of 12 h | 1992 | Journal of medicinal chemistry, Dec-25, Volume: 35, Issue:26
| Antimitotic agents: ring analogues and derivatives of ethyl [(S)-5-amino-1,2-dihydro-2-methyl-3-phenylpyrido[3,4-b]pyrazin-7- yl]carbamate. |
| AID115656 | Compound was evaluated in vivo for antileukemic activity by calculating Percent increase in life span at dose of 1 mg/kg | 1992 | Journal of medicinal chemistry, Dec-25, Volume: 35, Issue:26
| Antimitotic agents: ring analogues and derivatives of ethyl [(S)-5-amino-1,2-dihydro-2-methyl-3-phenylpyrido[3,4-b]pyrazin-7- yl]carbamate. |
| AID96603 | The compound was tested in vitro for mitotic inhibition against proliferation of cultured lymphoid leukemia L1210 cells | 1992 | Journal of medicinal chemistry, Mar-20, Volume: 35, Issue:6
| Antimitotic agents. Chiral isomers of ethyl [5-amino-1,2-dihydro-3-(4-hydroxyphenyl)-2-methylpyrido[3,4-b]pyrazin-7 -yl]carbamate. |
| AID98350 | Inhibitory activity against lymphoid leukemia L1210 cells | 1989 | Journal of medicinal chemistry, Sep, Volume: 32, Issue:9
| New anticancer agents: chiral isomers of ethyl 5-amino-1,2-dihydro-2-methyl-3-phenylpyrido[3,4-b]pyrazine-7-car bamate . |
| AID152879 | The compound was tested in vivo for percent increase in life span against lymphocytic leukemia P388 in mice after intraperitoneal administration of 1 mg/kg dose | 1992 | Journal of medicinal chemistry, Mar-20, Volume: 35, Issue:6
| Antimitotic agents. Chiral isomers of ethyl [5-amino-1,2-dihydro-3-(4-hydroxyphenyl)-2-methylpyrido[3,4-b]pyrazin-7 -yl]carbamate. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |