N6-(4-hydroxybenzyl)adenine riboside: neuroprotective compound from Gastrodia elata; structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
| Flora | Rank | Flora Definition | Family | Family Definition |
|---|---|---|---|---|
| Gastrodia | genus | A plant genus of the family ORCHIDACEAE which depends on the fungus Armillaria mellea to complete its life cycle. It is an ingredient of Zhenxuanyin (DRUGS, CHINESE HERBAL).[MeSH] | Orchidaceae | A plant family of the order Asparagales. All members of the orchid family have the same bilaterally symmetrical flower structure, with three sepals, but the flowers vary greatly in color and shape.[MeSH] |
| ID Source | ID |
|---|---|
| PubMed CID | 10474479 |
| CHEMBL ID | 224024 |
| SCHEMBL ID | 639446 |
| MeSH ID | M0509824 |
| Synonym |
|---|
| (2r,3s,4r,5r)-2-(hydroxymethyl)-5-[6-[(4-hydroxyphenyl)methylamino]purin-9-yl]oxolane-3,4-diol |
| n6-(4-hydroxybenzyl)adenine riboside |
| CHEMBL224024 , |
| n6-(p-hydroxybenzyl)-adenosine |
| UGVIXKXYLBAZND-LSCFUAHRSA-N |
| bdbm50208945 |
| n6-(4-hydroxybenzyl)-adenosine |
| 110505-75-4 |
| n6-(4-hydroxybenzyl)adenosine |
| AKOS016007097 |
| SCHEMBL639446 |
| CS-5067 |
| HY-18775 |
| DTXSID00440568 |
| 6-(p-hydroxybenzylamino)-9-beta-d-ribofuranosylpurine |
| NCGC00484059-01 |
| n6-(4-hydroxybenzyl) adenine riboside, >=98% (hplc) |
| n6-(4-hydroxybenzyl) adenine riboside |
| para-topolin riboside |
| para-topolin riboside; n-[(4-hydroxyphenyl)methyl]adenosine;(2r,3r,4s,5r)-2-(6-((4-hydroxybenzyl)amino)-9h-purin-9-yl)-5-(hydroxymethyl)tetrahydrofuran-3,4-diol;n6-(4-hydroxybenzyl)-adenosine |
| A900363 |
| F85288 |
| MS-26025 |
| n-[(4-hydroxyphenyl)methyl]adenosine |
| T9R , |
| Excerpt | Reference | Relevance |
|---|---|---|
| "The ATP-binding cassette transporter P-glycoprotein (P-gp) is known to limit both brain penetration and oral bioavailability of many chemotherapy drugs." | ( A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. Ambudkar, SV; Brimacombe, KR; Chen, L; Gottesman, MM; Guha, R; Hall, MD; Klumpp-Thomas, C; Lee, OW; Lee, TD; Lusvarghi, S; Robey, RW; Shen, M; Tebase, BG, 2019) | 0.51 |
| Assay ID | Title | Year | Journal | Article |
|---|---|---|---|---|
| AID283814 | Binding affinity to adenosine A2A receptor in rat brain striatum | 2007 | Journal of natural products, Apr, Volume: 70, Issue:4 | Neuroprotective principles from Gastrodia elata. |
| AID283813 | Prevention of serum deprivation-induced PC12 cell apoptosis by MTT assay | 2007 | Journal of natural products, Apr, Volume: 70, Issue:4 | Neuroprotective principles from Gastrodia elata. |
| AID1175339 | Inhibition of collagen-induced human platelet aggregation after 3 mins by light transmission aggregometry | 2014 | Bioorganic & medicinal chemistry letters, Dec-15, Volume: 24, Issue:24 | Naturally occurring N(6)-substituted adenosines (cytokinin ribosides) are in vitro inhibitors of platelet aggregation: an in silico evaluation of their interaction with the P2Y(12) receptor. |
| AID1296008 | Cytotoxic Profiling of Annotated Libraries Using Quantitative High-Throughput Screening | 2020 | SLAS discovery : advancing life sciences R & D, 01, Volume: 25, Issue:1 | Cytotoxic Profiling of Annotated and Diverse Chemical Libraries Using Quantitative High-Throughput Screening. |
| AID1346986 | P-glycoprotein substrates identified in KB-3-1 adenocarcinoma cell line, qHTS therapeutic library screen | 2019 | Molecular pharmacology, 11, Volume: 96, Issue:5 | A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. |
| AID1347159 | Primary screen GU Rhodamine qHTS for Zika virus inhibitors: Unlinked NS2B-NS3 protease assay | 2020 | Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49 | Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors. |
| AID1346987 | P-glycoprotein substrates identified in KB-8-5-11 adenocarcinoma cell line, qHTS therapeutic library screen | 2019 | Molecular pharmacology, 11, Volume: 96, Issue:5 | A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. |
| AID1347160 | Primary screen NINDS Rhodamine qHTS for Zika virus inhibitors | 2020 | Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49 | Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||||
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (8.33) | 29.6817 |
| 2010's | 8 (66.67) | 24.3611 |
| 2020's | 3 (25.00) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.
| This Compound (13.21) All Compounds (24.57) |
| Publication Type | This drug (%) | All Drugs (%) |
|---|---|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 0 (0.00%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 12 (100.00%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||