Compounds > murrayafoline a
Page last updated: 2024-12-08

murrayafoline a

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

murrayafoline A: structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID375150
CHEMBL ID490667
SCHEMBL ID19127730
MeSH IDM0410550

Synonyms (24)

Synonym
NCI60_018848
nsc-654284
nsc654284
9h-carbazole, 1-methoxy-3-methyl-
1-methoxy-3-methyl-9h-carbazole
murrayafoline a
CHEMBL490667
4532-33-6
AKOS016005765
HDETUOZJFUNSKG-UHFFFAOYSA-N
1-methoxy-3-methyl-9h-carbazole #
murrayafolin a
AC-29647
DTXSID90327415
mfcd18452402
SCHEMBL19127730
ncgc00385438-01!1-methoxy-3-methyl-9h-carbazole
1-methoxy-3-methylcarbazole
SY042489
F31078
DS-14611
EN300-217286
A872400
CS-0152929

Research Excerpts

Overview

Murrayafoline A is a naturally occurring vasoactive agent able to modulate Cav 1.2 channels and dock at the α1C subunit central pore.

ExcerptReferenceRelevance
"Murrayafoline A is a naturally occurring vasoactive agent able to modulate Cav 1.2 channels and dock at the α1C subunit central pore in a manner that differed from that of dihydropyridines."( Functional, electrophysiological and molecular docking analysis of the modulation of Cav 1.2 channels in rat vascular myocytes by murrayafoline A.
Cuong, NM; Durante, M; Fusi, F; Huong, TT; Khanh, PN; Mugnai, P; Saponara, S; Sgaragli, G; Son, NT; Spiga, O, 2016)		2.08
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (52)

Assay IDTitleYearJournalArticle
AID376163Growth inhibition of human SK-MEL-28 cells2000Journal of natural products, Jul, Volume: 63, Issue:7
Antitumor agents. 203. Carbazole alkaloid murrayaquinone A and related synthetic carbazolequinones as cytotoxic agents.
AID376183Growth inhibition of human DLD1 cells2000Journal of natural products, Jul, Volume: 63, Issue:7
Antitumor agents. 203. Carbazole alkaloid murrayaquinone A and related synthetic carbazolequinones as cytotoxic agents.
AID376169Growth inhibition of human XF498 cells2000Journal of natural products, Jul, Volume: 63, Issue:7
Antitumor agents. 203. Carbazole alkaloid murrayaquinone A and related synthetic carbazolequinones as cytotoxic agents.
AID376159Growth inhibition of human IGROV1 cells2000Journal of natural products, Jul, Volume: 63, Issue:7
Antitumor agents. 203. Carbazole alkaloid murrayaquinone A and related synthetic carbazolequinones as cytotoxic agents.
AID376151Growth inhibition of human ACHN cells2000Journal of natural products, Jul, Volume: 63, Issue:7
Antitumor agents. 203. Carbazole alkaloid murrayaquinone A and related synthetic carbazolequinones as cytotoxic agents.
AID376199Growth inhibition of human RPMI8266 cells2000Journal of natural products, Jul, Volume: 63, Issue:7
Antitumor agents. 203. Carbazole alkaloid murrayaquinone A and related synthetic carbazolequinones as cytotoxic agents.
AID376197Growth inhibition of human A549 cells2000Journal of natural products, Jul, Volume: 63, Issue:7
Antitumor agents. 203. Carbazole alkaloid murrayaquinone A and related synthetic carbazolequinones as cytotoxic agents.
AID376185Growth inhibition of human DMS273 cells2000Journal of natural products, Jul, Volume: 63, Issue:7
Antitumor agents. 203. Carbazole alkaloid murrayaquinone A and related synthetic carbazolequinones as cytotoxic agents.
AID376153Growth inhibition of human 786-0 cells2000Journal of natural products, Jul, Volume: 63, Issue:7
Antitumor agents. 203. Carbazole alkaloid murrayaquinone A and related synthetic carbazolequinones as cytotoxic agents.
AID376182Growth inhibition of human HCC2998 cells2000Journal of natural products, Jul, Volume: 63, Issue:7
Antitumor agents. 203. Carbazole alkaloid murrayaquinone A and related synthetic carbazolequinones as cytotoxic agents.
AID376175Growth inhibition of human SF268 cells2000Journal of natural products, Jul, Volume: 63, Issue:7
Antitumor agents. 203. Carbazole alkaloid murrayaquinone A and related synthetic carbazolequinones as cytotoxic agents.
AID376165Growth inhibition of human M19-MEL cells2000Journal of natural products, Jul, Volume: 63, Issue:7
Antitumor agents. 203. Carbazole alkaloid murrayaquinone A and related synthetic carbazolequinones as cytotoxic agents.
AID376166Growth inhibition of human M14 cells2000Journal of natural products, Jul, Volume: 63, Issue:7
Antitumor agents. 203. Carbazole alkaloid murrayaquinone A and related synthetic carbazolequinones as cytotoxic agents.
AID376147Growth inhibition of human TK10 cells2000Journal of natural products, Jul, Volume: 63, Issue:7
Antitumor agents. 203. Carbazole alkaloid murrayaquinone A and related synthetic carbazolequinones as cytotoxic agents.
AID376146Growth inhibition of human UO31 cells2000Journal of natural products, Jul, Volume: 63, Issue:7
Antitumor agents. 203. Carbazole alkaloid murrayaquinone A and related synthetic carbazolequinones as cytotoxic agents.
AID376186Growth inhibition of human DMS144 cells2000Journal of natural products, Jul, Volume: 63, Issue:7
Antitumor agents. 203. Carbazole alkaloid murrayaquinone A and related synthetic carbazolequinones as cytotoxic agents.
AID376180Growth inhibition of human HCT15 cells2000Journal of natural products, Jul, Volume: 63, Issue:7
Antitumor agents. 203. Carbazole alkaloid murrayaquinone A and related synthetic carbazolequinones as cytotoxic agents.
AID376160Growth inhibition of human UACC62 cells2000Journal of natural products, Jul, Volume: 63, Issue:7
Antitumor agents. 203. Carbazole alkaloid murrayaquinone A and related synthetic carbazolequinones as cytotoxic agents.
AID376189Growth inhibition of human NCI-H460 cells2000Journal of natural products, Jul, Volume: 63, Issue:7
Antitumor agents. 203. Carbazole alkaloid murrayaquinone A and related synthetic carbazolequinones as cytotoxic agents.
AID376157Growth inhibition of human OVACR4 cells2000Journal of natural products, Jul, Volume: 63, Issue:7
Antitumor agents. 203. Carbazole alkaloid murrayaquinone A and related synthetic carbazolequinones as cytotoxic agents.
AID376198Growth inhibition of human SR cells2000Journal of natural products, Jul, Volume: 63, Issue:7
Antitumor agents. 203. Carbazole alkaloid murrayaquinone A and related synthetic carbazolequinones as cytotoxic agents.
AID376188Growth inhibition of human NCI-H522 cells2000Journal of natural products, Jul, Volume: 63, Issue:7
Antitumor agents. 203. Carbazole alkaloid murrayaquinone A and related synthetic carbazolequinones as cytotoxic agents.
AID376171Growth inhibition of human SNB75 cells2000Journal of natural products, Jul, Volume: 63, Issue:7
Antitumor agents. 203. Carbazole alkaloid murrayaquinone A and related synthetic carbazolequinones as cytotoxic agents.
AID376203Growth inhibition of human CCRF-CEM cells2000Journal of natural products, Jul, Volume: 63, Issue:7
Antitumor agents. 203. Carbazole alkaloid murrayaquinone A and related synthetic carbazolequinones as cytotoxic agents.
AID376176Growth inhibition of human SW620 cells2000Journal of natural products, Jul, Volume: 63, Issue:7
Antitumor agents. 203. Carbazole alkaloid murrayaquinone A and related synthetic carbazolequinones as cytotoxic agents.
AID376170Growth inhibition of human U251 cells2000Journal of natural products, Jul, Volume: 63, Issue:7
Antitumor agents. 203. Carbazole alkaloid murrayaquinone A and related synthetic carbazolequinones as cytotoxic agents.
AID376168Growth inhibition of human LOX IMVI cells2000Journal of natural products, Jul, Volume: 63, Issue:7
Antitumor agents. 203. Carbazole alkaloid murrayaquinone A and related synthetic carbazolequinones as cytotoxic agents.
AID376193Growth inhibition of human HOP92 cells2000Journal of natural products, Jul, Volume: 63, Issue:7
Antitumor agents. 203. Carbazole alkaloid murrayaquinone A and related synthetic carbazolequinones as cytotoxic agents.
AID376148Growth inhibition of human SN12C cells2000Journal of natural products, Jul, Volume: 63, Issue:7
Antitumor agents. 203. Carbazole alkaloid murrayaquinone A and related synthetic carbazolequinones as cytotoxic agents.
AID376172Growth inhibition of human SNB19 cells2000Journal of natural products, Jul, Volume: 63, Issue:7
Antitumor agents. 203. Carbazole alkaloid murrayaquinone A and related synthetic carbazolequinones as cytotoxic agents.
AID376178Growth inhibition of human KM12 cells2000Journal of natural products, Jul, Volume: 63, Issue:7
Antitumor agents. 203. Carbazole alkaloid murrayaquinone A and related synthetic carbazolequinones as cytotoxic agents.
AID376181Growth inhibition of human HCT116 cells2000Journal of natural products, Jul, Volume: 63, Issue:7
Antitumor agents. 203. Carbazole alkaloid murrayaquinone A and related synthetic carbazolequinones as cytotoxic agents.
AID376179Growth inhibition of human HT29 cells2000Journal of natural products, Jul, Volume: 63, Issue:7
Antitumor agents. 203. Carbazole alkaloid murrayaquinone A and related synthetic carbazolequinones as cytotoxic agents.
AID376149Growth inhibition of human RFX393 cells2000Journal of natural products, Jul, Volume: 63, Issue:7
Antitumor agents. 203. Carbazole alkaloid murrayaquinone A and related synthetic carbazolequinones as cytotoxic agents.
AID376195Growth inhibition of human HOP18 cells2000Journal of natural products, Jul, Volume: 63, Issue:7
Antitumor agents. 203. Carbazole alkaloid murrayaquinone A and related synthetic carbazolequinones as cytotoxic agents.
AID376187Growth inhibition of human LXFL529 cells2000Journal of natural products, Jul, Volume: 63, Issue:7
Antitumor agents. 203. Carbazole alkaloid murrayaquinone A and related synthetic carbazolequinones as cytotoxic agents.
AID376155Growth inhibition of human OVACR8 cells2000Journal of natural products, Jul, Volume: 63, Issue:7
Antitumor agents. 203. Carbazole alkaloid murrayaquinone A and related synthetic carbazolequinones as cytotoxic agents.
AID376200Growth inhibition of human MOLT4 cells2000Journal of natural products, Jul, Volume: 63, Issue:7
Antitumor agents. 203. Carbazole alkaloid murrayaquinone A and related synthetic carbazolequinones as cytotoxic agents.
AID376202Growth inhibition of human HL60(TB) cells2000Journal of natural products, Jul, Volume: 63, Issue:7
Antitumor agents. 203. Carbazole alkaloid murrayaquinone A and related synthetic carbazolequinones as cytotoxic agents.
AID376158Growth inhibition of human OVACR3 cells2000Journal of natural products, Jul, Volume: 63, Issue:7
Antitumor agents. 203. Carbazole alkaloid murrayaquinone A and related synthetic carbazolequinones as cytotoxic agents.
AID376192Growth inhibition of human NCI-H226 cells2000Journal of natural products, Jul, Volume: 63, Issue:7
Antitumor agents. 203. Carbazole alkaloid murrayaquinone A and related synthetic carbazolequinones as cytotoxic agents.
AID376194Growth inhibition of human HOP62 cells2000Journal of natural products, Jul, Volume: 63, Issue:7
Antitumor agents. 203. Carbazole alkaloid murrayaquinone A and related synthetic carbazolequinones as cytotoxic agents.
AID376162Growth inhibition of human SK-MEL-5 cells2000Journal of natural products, Jul, Volume: 63, Issue:7
Antitumor agents. 203. Carbazole alkaloid murrayaquinone A and related synthetic carbazolequinones as cytotoxic agents.
AID376167Growth inhibition of human MALME-3M cells2000Journal of natural products, Jul, Volume: 63, Issue:7
Antitumor agents. 203. Carbazole alkaloid murrayaquinone A and related synthetic carbazolequinones as cytotoxic agents.
AID376156Growth inhibition of human OVACR5 cells2000Journal of natural products, Jul, Volume: 63, Issue:7
Antitumor agents. 203. Carbazole alkaloid murrayaquinone A and related synthetic carbazolequinones as cytotoxic agents.
AID376184Growth inhibition of human COLO205 cells2000Journal of natural products, Jul, Volume: 63, Issue:7
Antitumor agents. 203. Carbazole alkaloid murrayaquinone A and related synthetic carbazolequinones as cytotoxic agents.
AID376201Growth inhibition of human K562 cells2000Journal of natural products, Jul, Volume: 63, Issue:7
Antitumor agents. 203. Carbazole alkaloid murrayaquinone A and related synthetic carbazolequinones as cytotoxic agents.
AID376154Growth inhibition of human SK-OV-3 cells2000Journal of natural products, Jul, Volume: 63, Issue:7
Antitumor agents. 203. Carbazole alkaloid murrayaquinone A and related synthetic carbazolequinones as cytotoxic agents.
AID376190Growth inhibition of human NCI-H322M cells2000Journal of natural products, Jul, Volume: 63, Issue:7
Antitumor agents. 203. Carbazole alkaloid murrayaquinone A and related synthetic carbazolequinones as cytotoxic agents.
AID376164Growth inhibition of human SK-MEL-2 cells2000Journal of natural products, Jul, Volume: 63, Issue:7
Antitumor agents. 203. Carbazole alkaloid murrayaquinone A and related synthetic carbazolequinones as cytotoxic agents.
AID376177Growth inhibition of human KM20L2 cells2000Journal of natural products, Jul, Volume: 63, Issue:7
Antitumor agents. 203. Carbazole alkaloid murrayaquinone A and related synthetic carbazolequinones as cytotoxic agents.
AID376173Growth inhibition of human SF539 cells2000Journal of natural products, Jul, Volume: 63, Issue:7
Antitumor agents. 203. Carbazole alkaloid murrayaquinone A and related synthetic carbazolequinones as cytotoxic agents.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (17)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's6 (35.29)29.6817
2010's9 (52.94)24.3611
2020's2 (11.76)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 17.50

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index17.50 (24.57)
Research Supply Index2.89 (2.92)
Research Growth Index5.21 (4.65)
Search Engine Demand Index10.37 (26.88)
Search Engine Supply Index2.00 (0.95)

This Compound (17.50)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other17 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
benzene
[no description available]		210aromatic annulene;
benzenes;
volatile organic compound		carcinogenic agent;
environmental contaminant;
non-polar solvent
chlorine
chloride : A halide anion formed when chlorine picks up an electron to form an an anion.		210halide anion;
monoatomic chlorine		cofactor;
Escherichia coli metabolite;
human metabolite
iodine
Iodine: A nonmetallic element of the halogen group that is represented by the atomic symbol I, atomic number 53, and atomic weight of 126.90. It is a nutritionally essential element, especially important in thyroid hormone synthesis. In solution, it has anti-infective properties and is used topically.. diiodine : Molecule comprising two covalently bonded iodine atoms with overall zero charge..		7.110diatomic iodinenutrient
verapamil
Verapamil: A calcium channel blocker that is a class IV anti-arrhythmia agent.. verapamil : A racemate comprising equimolar amounts of dexverapamil and (S)-verapamil. An L-type calcium channel blocker of the phenylalkylamine class, it is used (particularly as the hydrochloride salt) in the treatment of hypertension, angina pectoris and cardiac arrhythmia, and as a preventive medication for migraine.. 2-(3,4-dimethoxyphenyl)-5-{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino}-2-(propan-2-yl)pentanenitrile : A tertiary amino compound that is 3,4-dimethoxyphenylethylamine in which the hydrogens attached to the nitrogen are replaced by a methyl group and a 4-cyano-4-(3,4-dimethoxyphenyl)-5-methylhexyl group.		2.110aromatic ether;
nitrile;
polyether;
tertiary amino compound
carbazole
carbazole: structure in first source		2.0410carbazole
palladium
Palladium: A chemical element having an atomic weight of 106.4, atomic number of 46, and the symbol Pd. It is a white, ductile metal resembling platinum, and following it in abundance and importance of applications. It is used in dentistry in the form of gold, silver, and copper alloys.. palladium : Chemical element (nickel group element atom) with atomic number 46.		2.4820metal allergen;
nickel group element atom;
platinum group metal atom
aluminum chloride
Aluminum Chloride: A compound with the chemical formula AlCl3; the anhydrous salt is used as a catalyst in organic chemical synthesis, and hydrated salts are used topically as antiperspirants, and for the management of HYPERHYDROSIS.		210aluminium coordination entityLewis acid
murrayanine
murrayanine: carbazole alkaloid from Murraya koenigii; structure in first source		2.0210carbazolesmetabolite
murrayaquinone a
murrayaquinone A: a carbazole alkaloid from Murraya (Rutaceae); structure given in first source		210
glycosides
[no description available]		2.0410
mahanine
mahanine: structure in first source		2.0210
ConditionIndicatedRelationship StrengthStudiesTrials
Benign Neoplasms
[description not available]		02.4110
Neoplasms
New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.		02.4110
Cancer of Colon
[description not available]		02.0510
Colonic Neoplasms
Tumors or cancer of the COLON.		02.0510