Page last updated: 2024-12-06
midesteine
Description
Midesteine is a synthetic compound that has been studied for its potential therapeutic effects. It is a derivative of N-acetylcysteine (NAC), a well-known antioxidant and mucolytic agent. Midesteine has shown promising results in preclinical studies for its ability to protect against oxidative stress, inflammation, and apoptosis. It has also been investigated for its potential to improve cognitive function and memory. The compound's mechanism of action is thought to involve its ability to enhance the activity of the antioxidant enzyme glutathione peroxidase. Midesteine has been studied for its potential use in the treatment of various conditions, including neurodegenerative diseases, cardiovascular disease, and respiratory disorders. Further research is ongoing to evaluate its clinical efficacy and safety.'
midesteine: a cyclic thiolic neutrophil elastase inhibitor [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
Cross-References
| ID Source | ID |
|---|
| PubMed CID | 65837 |
| CHEMBL ID | 1808549 |
| SCHEMBL ID | 724755 |
| MeSH ID | M0171887 |
Synonyms (24)
| Synonym |
|---|
| mr-889 |
| midesteine |
| 2-thiophenecarbothioic acid, s-(1-methyl-2-oxo-2-((tetrahydro-2-oxo-3-thienyl)amino)ethyl) ester |
| midesteinum [inn-latin] |
| 2-thiophenecarbothioic acid, s-ester with (+-)-2-mercapto-n-(tetrahydro-2-oxo-3-thienyl)propionamide |
| mr 889 |
| 2-(thiophen-2-ylcarbonylthio)-n-(2-oxo-2,3,4,5-tetrahydrothiophen-3-yl)propionamide |
| midesteine [inn] |
| midesteina [inn-spanish] |
| s-[1-oxo-1-[(2-oxothiolan-3-yl)amino]propan-2-yl] thiophene-2-carbothioate |
| CHEMBL1808549 , |
| midesteinum |
| 90k2ye9fto , |
| unii-90k2ye9fto |
| midesteina |
| 94149-41-4 |
| bdbm50349435 |
| SCHEMBL724755 |
| 2-thiophenecarbothioic acid, s-ester with (+/-)-2-mercapto-n-(tetrahydro-2-oxo-3-thienyl)propionamide |
| n-(2-oxo-2,3,4,5-tetrahydro-3-thienyl)-2-(2-thienylcarbonylthio)propionamide |
| SB19618 |
| Q27271333 |
| DTXSID00869194 |
| s-{1-oxo-1-[(2-oxothiolan-3-yl)amino]propan-2-yl} thiophene-2-carbothioate |
Protein Targets (1)
Inhibition Measurements
Biological Processes (25)
Molecular Functions (8)
Ceullar Components (12)
Research
Studies (8)
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|
| pre-1990 | 1 (12.50) | 18.7374 |
| 1990's | 5 (62.50) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 2 (25.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] |
Market Indicators
Research Demand Index: 12.62
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.
| Metric | This Compound (vs All) |
|---|
| Research Demand Index | 12.62 (24.57) | | Research Supply Index | 2.30 (2.92) | | Research Growth Index | 4.92 (4.65) | | Search Engine Demand Index | 0.00 (26.88) | | Search Engine Supply Index | 0.00 (0.95) |
| |
Study Types
| Publication Type | This drug (%) | All Drugs (%) |
|---|
| Trials | 1 (12.50%) | 5.53% |
| Reviews | 1 (12.50%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 6 (75.00%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] |