Compounds > men 4901
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men 4901

Description

T 0128: a T-2153 prodrug; structure in first source [MeSH]

Cross-References

ID SourceID
PubMed CID71300577
MeSH IDM0487440

Synonyms (20)

Synonym
t 0128
unii-b2k8l0ie7t
men4901
delimotecan
187852-63-7
delimotecan [inn]
b2k8l0ie7t ,
men-4901
men 4901
glycinamide, glycylglycyl-n-(3-(((4s)-4,11-diethyl-3,4,12,14-tetrahydro-4-hydroxy-3,14-dioxo-1h-pyrano(3',4':6,7)indolizino(1,2-b)quinolin-9-yl)oxy)propyl)-
unii-2617l083nz
2617l083nz ,
t-2513-gly-gly-gly
187803-34-5
DTXSID00172099 ,
glycinamide, glycylglycyl-n-(3-(((4s)-4,11-diethyl-3,4,12,14-tetrahydro-4-hydroxy-3,14-dioxo-1h-pyrano(3',4':6,7)indolizino(1,2-b)quinolin-9-yl)oxy)propyl)-, compd. with dextran carboxymethyl ether
58084298V3 ,
delimotecanum
dtxcid8094590
AKOS040748229

Research

Studies (10)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's9 (90.00)29.6817
2010's1 (10.00)24.3611
2020's0 (0.00)2.80

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials1 (10.00%)5.53%
Reviews1 (10.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other8 (80.00%)84.16%
SubstanceStudiesClassesRolesFirst YearLast YearAverage AgeRelationship StrengthTrialspre-19901990's2000's2010'spost-2020
leucine
1
amino acid zwitterion;
L-alpha-amino acid;
leucine;
proteinogenic amino acid;
pyruvate family amino acid		algal metabolite;
Escherichia coli metabolite;
human metabolite;
mouse metabolite;
plant metabolite;
Saccharomyces cerevisiae metabolite		2000200024.0low001000
camptothecin
6
delta-lactone;
pyranoindolizinoquinoline;
quinoline alkaloid;
tertiary alcohol		antineoplastic agent;
EC 5.99.1.2 (DNA topoisomerase) inhibitor;
genotoxin;
plant metabolite		2000201119.3high001410
n-(2-hydroxypropyl)methacrylamide
1
2005200519.0low000100
topotecan
10
pyranoindolizinoquinolineantineoplastic agent;
EC 5.99.1.2 (DNA topoisomerase) inhibitor		2000201119.5high103610
irinotecan
2
carbamate ester;
delta-lactone;
N-acylpiperidine;
pyranoindolizinoquinoline;
ring assembly;
tertiary alcohol;
tertiary amino compound		antineoplastic agent;
apoptosis inducer;
EC 5.99.1.2 (DNA topoisomerase) inhibitor;
prodrug		2005201116.0low000110
e 64
1
dicarboxylic acid monoamide;
epoxy monocarboxylic acid;
guanidines;
L-leucine derivative;
zwitterion		antimalarial;
antiparasitic agent;
protease inhibitor		2000200024.0low001000
ConditionIndicatedStudiesFirst YearLast YearAverage AgeRelationship StrengthTrialspre-19901990's2000's2010'spost-2020
Adenocarcinoma0
1
2011201113.0low000010
Adenocarcinoma, Basal Cell0
1
2011201113.0low000010
Benign Neoplasms0
1
2008200816.0low100100
Body Weight0
2
2005201116.0low000110
Breast Cancer0
1
2000200024.0low001000
Breast Neoplasms0
1
2000200024.0low001000
Cancer of Colon0
2
2009201114.0low000110
Cancer of Lung0
1
2000200024.0low001000
Cancer of Ovary0
1
2009200915.0low000100
Colonic Neoplasms0
2
2009201114.0low000110
Experimental Mammary Neoplasms0
1
2000200024.0low001000
Experimental Neoplasms0
1
2001200123.0low000100
Granulocytic Leukemia0
1
2009200915.0low000100
Leukemia, Myeloid0
1
2009200915.0low000100
Lung Neoplasms0
1
2000200024.0low001000
Malignant Melanoma0
1
2009200915.0low000100
Melanoma0
1
2009200915.0low000100
Neoplasms0
1
2008200816.0low100100
Ovarian Neoplasms0
1
2009200915.0low000100

Pharmacokinetics (2)

ArticleYear
Antitumor activity of delimotecan against human metastatic melanoma: pharmacokinetics and molecular determinants.
International journal of cancer, , Nov-15, Volume: 125, Issue:10		2009
Carrier and dose effects on the pharmacokinetics of T-0128, a camptothecin analogue-carboxymethyl dextran conjugate, in non-tumor- and tumor-bearing rats.
Journal of controlled release : official journal of the Controlled Release Society, , Mar-12, Volume: 71, Issue:1		2001

Dosage (1)

ArticleYear
Determinants for the drug release from T-0128, camptothecin analogue-carboxymethyl dextran conjugate.
Journal of controlled release : official journal of the Controlled Release Society, , Dec-03, Volume: 69, Issue:3		2000