Page last updated: 2024-12-05
meconic acid
Description
meconic acid: most alkaloids from opium are present in form of meconates; meconic acid is strictly peculiar to opium; from papaver; structure [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
Cross-References
| ID Source | ID |
|---|
| PubMed CID | 10347 |
| CHEMBL ID | 109516 |
| CHEBI ID | 166570 |
| SCHEMBL ID | 600257 |
| SCHEMBL ID | 546968 |
| MeSH ID | M0056199 |
Synonyms (32)
| Synonym |
|---|
| 4h-pyran-2,6-dicarboxylic acid, 3-hydroxy-4-oxo- |
| nsc 805 |
| einecs 207-848-2 |
| unii-v502i79516 |
| v502i79516 , |
| bdbm50147502 |
| CHEBI:166570 |
| 3-hydroxy-4-oxopyran-2,6-dicarboxylic acid |
| poppy acid |
| 3-hydroxy-4-oxo-4h-pyran-2,6-dicarboxylic acid |
| 3-hydroxy-4-oxo-pyran-2,6-dicarboxylic acid |
| meconic acid |
| nsc-805 |
| nsc805 , |
| 497-59-6 |
| 4h-pyran-2, 3-hydroxy-4-oxo- |
| CHEMBL109516 , |
| 3-hydroxy-4-oxo-1,4-pyran-2,6-dicarboxylic acid |
| C20209 |
| meconic acid [mi] |
| oxychelidonic acid |
| SCHEMBL600257 |
| SCHEMBL546968 |
| DTXSID2060096 |
| mekonsaure |
| 3-hydroxy-4-pyrone-2,6-dicarboxylic acid |
| opium acid |
| AKOS030554055 |
| FT-0710230 |
| Q421116 |
| noname_429 |
| DTXSID20901328 |
Drug Classes (1)
| Class | Description |
|---|
| pyranone | Any of a class of cyclic chemical compounds that contain an unsaturated six-membered ring with one ring oxygen atom and an oxo substituent. |
| [compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res] |
Protein Targets (1)
Inhibition Measurements
Ceullar Components (1)
| Process | via Protein(s) | Taxonomy |
|---|
| [Information is prepared from geneontology information from the June-17-2024 release] |
Bioassays (4)
| Assay ID | Title | Year | Journal | Article |
|---|
| AID146536 | Inhibitory potency against NS5B HCV polymerase | 2004 | Bioorganic & medicinal chemistry letters, Jun-21, Volume: 14, Issue:12
| The monoethyl ester of meconic acid is an active site inhibitor of HCV NS5B RNA-dependent RNA polymerase. |
| AID146538 | Inhibitory potency of compound in presence of Mn2+ ion against NS5B HCV polymerase | 2004 | Bioorganic & medicinal chemistry letters, Jun-21, Volume: 14, Issue:12
| The monoethyl ester of meconic acid is an active site inhibitor of HCV NS5B RNA-dependent RNA polymerase. |
| AID146537 | Inhibitory potency of compound in presence of Mg2+ ion against NS5B HCV polymerase | 2004 | Bioorganic & medicinal chemistry letters, Jun-21, Volume: 14, Issue:12
| The monoethyl ester of meconic acid is an active site inhibitor of HCV NS5B RNA-dependent RNA polymerase. |
| AID86863 | Tested for inhibition of HCV RNA replication in a cell-basedassay; No significant inhibition | 2004 | Bioorganic & medicinal chemistry letters, Jun-21, Volume: 14, Issue:12
| The monoethyl ester of meconic acid is an active site inhibitor of HCV NS5B RNA-dependent RNA polymerase. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |
Research
Studies (14)
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|
| pre-1990 | 11 (78.57) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (14.29) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 1 (7.14) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] |
Market Indicators
Research Demand Index: 36.69
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be strong demand-to-supply ratio for research on this compound.
| Metric | This Compound (vs All) |
|---|
| Research Demand Index | 36.69 (24.57) | | Research Supply Index | 2.71 (2.92) | | Research Growth Index | 4.16 (4.65) | | Search Engine Demand Index | 50.49 (26.88) | | Search Engine Supply Index | 2.00 (0.95) |
| |
Study Types
| Publication Type | This drug (%) | All Drugs (%) |
|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 0 (0.00%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 14 (100.00%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] |