Page last updated: 2024-12-05

chelidonic acid

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Chelidonic acid is a naturally occurring organic compound with the formula C7H4O6. It is a white crystalline solid that is soluble in water. Chelidonic acid is found in a variety of plants, including the greater celandine (Chelidonium majus) from which it derives its name. It has been reported to have various biological activities, including antimicrobial, anti-inflammatory, and antioxidant effects. Chelidonic acid is also used as a reagent in organic synthesis and as an indicator in analytical chemistry. Studies on chelidonic acid are conducted to explore its potential pharmacological applications, understand its biosynthesis in plants, and investigate its role in plant defense mechanisms. Chelidonic acid has also been investigated for its potential as a natural pesticide.'

Cross-References

ID SourceID
PubMed CID7431
CHEBI ID3586
SCHEMBL ID70569
MeSH IDM0135627

Synonyms (69)

Synonym
c7h4o6
BB 0221249
4-oxo-pyran-2,6-dicarboxylic acid
.gamma.-pyrone-2,6-dicarboxylic acid
wln: t6o dvj bvq fvq
jervaic acid
compound xi* (cherry and hageman)
nsc3979 ,
jervasic acid
4-oxo-1,6-dicarboxylic acid
jerva acid
compound xi*
nsc-3979
2,6-dicarboxyl-4-pyrone
4h-pyran-2, 4-oxo-
TIMTEC1_001281
ai3-19253
gamma-pyrone-2,6-dicarboxylic acid
4h-pyran-2,6-dicarboxylic acid, 4-oxo-
4-oxo-1,4-pyran-2,6-dicarboxylic acid
nsc 3979
einecs 202-749-0
brn 0163607
4-oxopyran-2,6-dicarboxylic acid
4-oxo-4h-pyran-2,6-dicarboxylic acid
C08476
chelidonic acid ,
99-32-1
chelidonic acid, 98%
NCGC00174597-01
HMS1537K05
C0955
AKOS003368630
pbaydyuzosnjgu-uhfffaoysa-
inchi=1/c7h4o6/c8-3-1-4(6(9)10)13-5(2-3)7(11)12/h1-2h,(h,9,10)(h,11,12)
STK735535
A19372
4-oxo-4h-pyran-2,6-dicarboxylicacid
t33u4w5k6o ,
5-18-08-00646 (beilstein handbook reference)
unii-t33u4w5k6o
BP-12076
FT-0623586
AR-360/40172582
chelidonic acid [mi]
HLD ,
S5579
2,6-dicarboxy-4-pyrone
SCHEMBL70569
CHEBI:3586
DS-1596
mfcd00006577
DTXSID30243928 ,
chelidonic acid, analytical standard
chelidonic acid, purum, anhydrous, >=98.0% (t)
chelidonsaure
CS-W022229
HY-W041489
Q908483
BBL037230
HMS3886K12
AMY36600
y-pyrone-2,6-dicarboxylic acid
CCG-266462
chelidonic acid (not validated)
EN300-82795
dtxcid60166419
SY031174
Z1238543360

Research Excerpts

Overview

Chelidonic acid (CA) is a γ-pyrone which is contained in the rhizome of Chelidonium majus L.

ExcerptReferenceRelevance
"Chelidonic acid (CA) is a γ-pyrone which is contained in the rhizome of Chelidonium majus L. "( Inhibitory effects of chelidonic acid on IL-6 production by blocking NF-κB and caspase-1 in HMC-1 cells.
Chung, WS; Kim, HL; Kim, SJ; Kim, SS; Shin, HJ; Um, JY, 2011
)
2.13
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Drug Classes (2)

ClassDescription
carbonyl compoundAny compound containing the carbonyl group, C=O. The term is commonly used in the restricted sense of aldehydes and ketones, although it actually includes carboxylic acids and derivatives.
pyrans
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Bioassays (2)

Assay IDTitleYearJournalArticle
AID540299A screen for compounds that inhibit the MenB enzyme of Mycobacterium tuberculosis2010Bioorganic & medicinal chemistry letters, Nov-01, Volume: 20, Issue:21
Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis.
AID588519A screen for compounds that inhibit viral RNA polymerase binding and polymerization activities2011Antiviral research, Sep, Volume: 91, Issue:3
High-throughput screening identification of poliovirus RNA-dependent RNA polymerase inhibitors.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (18)

TimeframeStudies, This Drug (%)All Drugs %
pre-19907 (38.89)18.7374
1990's0 (0.00)18.2507
2000's1 (5.56)29.6817
2010's10 (55.56)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 29.29

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index29.29 (24.57)
Research Supply Index2.94 (2.92)
Research Growth Index5.05 (4.65)
Search Engine Demand Index34.37 (26.88)
Search Engine Supply Index2.00 (0.95)

This Compound (29.29)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other18 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]