chelidonic acid

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Chelidonic acid is a naturally occurring organic compound with the formula C7H4O6. It is a white crystalline solid that is soluble in water. Chelidonic acid is found in a variety of plants, including the greater celandine (Chelidonium majus) from which it derives its name. It has been reported to have various biological activities, including antimicrobial, anti-inflammatory, and antioxidant effects. Chelidonic acid is also used as a reagent in organic synthesis and as an indicator in analytical chemistry. Studies on chelidonic acid are conducted to explore its potential pharmacological applications, understand its biosynthesis in plants, and investigate its role in plant defense mechanisms. Chelidonic acid has also been investigated for its potential as a natural pesticide.'

Cross-References

ID Source	ID
PubMed CID	7431
CHEBI ID	3586
SCHEMBL ID	70569
MeSH ID	M0135627

Synonyms (69)

Synonym
c7h4o6
BB 0221249
4-oxo-pyran-2,6-dicarboxylic acid
.gamma.-pyrone-2,6-dicarboxylic acid
wln: t6o dvj bvq fvq
jervaic acid
compound xi* (cherry and hageman)
nsc3979 ,
jervasic acid
4-oxo-1,6-dicarboxylic acid
jerva acid
compound xi*
nsc-3979
2,6-dicarboxyl-4-pyrone
4h-pyran-2, 4-oxo-
TIMTEC1_001281
ai3-19253
gamma-pyrone-2,6-dicarboxylic acid
4h-pyran-2,6-dicarboxylic acid, 4-oxo-
4-oxo-1,4-pyran-2,6-dicarboxylic acid
nsc 3979
einecs 202-749-0
brn 0163607
4-oxopyran-2,6-dicarboxylic acid
4-oxo-4h-pyran-2,6-dicarboxylic acid
C08476
chelidonic acid ,
99-32-1
chelidonic acid, 98%
NCGC00174597-01
HMS1537K05
C0955
AKOS003368630
pbaydyuzosnjgu-uhfffaoysa-
inchi=1/c7h4o6/c8-3-1-4(6(9)10)13-5(2-3)7(11)12/h1-2h,(h,9,10)(h,11,12)
STK735535
A19372
4-oxo-4h-pyran-2,6-dicarboxylicacid
t33u4w5k6o ,
5-18-08-00646 (beilstein handbook reference)
unii-t33u4w5k6o
BP-12076
FT-0623586
AR-360/40172582
chelidonic acid [mi]
HLD ,
S5579
2,6-dicarboxy-4-pyrone
SCHEMBL70569
CHEBI:3586
DS-1596
mfcd00006577
DTXSID30243928 ,
chelidonic acid, analytical standard
chelidonic acid, purum, anhydrous, >=98.0% (t)
chelidonsaure
CS-W022229
HY-W041489
Q908483
BBL037230
HMS3886K12
AMY36600
y-pyrone-2,6-dicarboxylic acid
CCG-266462
chelidonic acid (not validated)
EN300-82795
dtxcid60166419
SY031174
Z1238543360

Research Excerpts

Overview

Chelidonic acid (CA) is a γ-pyrone which is contained in the rhizome of Chelidonium majus L.

Excerpt	Reference	Relevance
"Chelidonic acid (CA) is a γ-pyrone which is contained in the rhizome of Chelidonium majus L. "	( Inhibitory effects of chelidonic acid on IL-6 production by blocking NF-κB and caspase-1 in HMC-1 cells. Chung, WS; Kim, HL; Kim, SJ; Kim, SS; Shin, HJ; Um, JY, 2011)	2.13

[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Drug Classes (2)

Class	Description
carbonyl compound	Any compound containing the carbonyl group, C=O. The term is commonly used in the restricted sense of aldehydes and ketones, although it actually includes carboxylic acids and derivatives.
pyrans
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Bioassays (2)

Assay ID	Title	Year	Journal	Article
AID540299	A screen for compounds that inhibit the MenB enzyme of Mycobacterium tuberculosis	2010	Bioorganic & medicinal chemistry letters, Nov-01, Volume: 20, Issue:21	Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis.
AID588519	A screen for compounds that inhibit viral RNA polymerase binding and polymerization activities	2011	Antiviral research, Sep, Volume: 91, Issue:3	High-throughput screening identification of poliovirus RNA-dependent RNA polymerase inhibitors.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (18)

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	7 (38.89)	18.7374
1990's	0 (0.00)	18.2507
2000's	1 (5.56)	29.6817
2010's	10 (55.56)	24.3611
2020's	0 (0.00)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 29.29

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

Metric	This Compound (vs All)
Research Demand Index	29.29 (24.57)
Research Supply Index	2.94 (2.92)
Research Growth Index	5.05 (4.65)
Search Engine Demand Index	34.37 (26.88)
Search Engine Supply Index	2.00 (0.95)

This Compound (29.29)

All Compounds (24.57)

Study Types

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	0 (0.00%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	18 (100.00%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
piperazine [no description available]	7.06	1	azacycloalkane; piperazines; saturated organic heteromonocyclic parent	anthelminthic drug
meconic acid meconic acid: most alkaloids from opium are present in form of meconates; meconic acid is strictly peculiar to opium; from papaver; structure	2.33	2	pyranone
dipicolinic acid dipicolinic acid : A pyridinedicarboxylic acid carrying two carboxy groups at positions 2 and 6.	2.1	1	pyridinedicarboxylic acid	bacterial metabolite
tetradecanoylphorbol acetate Tetradecanoylphorbol Acetate: A phorbol ester found in CROTON OIL with very effective tumor promoting activity. It stimulates the synthesis of both DNA and RNA.. phorbol ester : Esters of phorbol, originally found in croton oil (from Croton tiglium, of the family Euphorbiaceae). A number of phorbol esters possess activity as tumour promoters and activate the mechanisms associated with cell growth. Some of these are used in experiments as activators of protein kinase C.. phorbol 13-acetate 12-myristate : A phorbol ester that is phorbol in which the hydroxy groups at the cyclopropane ring juction (position 13) and the adjacent carbon (position 12) have been converted into the corresponding acetate and myristate esters. It is a major active constituent of the seed oil of Croton tiglium. It has been used as a tumour promoting agent for skin carcinogenesis in rodents and is associated with increased cell proliferation of malignant cells. However its function is controversial since a decrease in cell proliferation has also been observed in several cancer cell types.	2.06	1	acetate ester; diester; phorbol ester; tertiary alpha-hydroxy ketone; tetradecanoate ester	antineoplastic agent; apoptosis inducer; carcinogenic agent; mitogen; plant metabolite; protein kinase C agonist; reactive oxygen species generator
ovalbumin Ovalbumin: An albumin obtained from the white of eggs. It is a member of the serpin superfamily.	2.49	2
dinoprostone prostaglandin E2 : Prostaglandin F2alpha in which the hydroxy group at position 9 has been oxidised to the corresponding ketone. Prostaglandin E2 is the most common and most biologically potent of mammalian prostaglandins.	2.07	1	prostaglandins E	human metabolite; mouse metabolite; oxytocic
calcimycin Calcimycin: An ionophorous, polyether antibiotic from Streptomyces chartreusensis. It binds and transports CALCIUM and other divalent cations across membranes and uncouples oxidative phosphorylation while inhibiting ATPase of rat liver mitochondria. The substance is used mostly as a biochemical tool to study the role of divalent cations in various biological systems.	2.06	1	benzoxazole
tannins Tannins: Polyphenolic compounds with molecular weights of around 500-3000 daltons and containing enough hydroxyl groups (1-2 per 100 MW) for effective cross linking of other compounds (ASTRINGENTS). The two main types are HYDROLYZABLE TANNINS and CONDENSED TANNINS. Historically, the term has applied to many compounds and plant extracts able to render skin COLLAGEN impervious to degradation. The word tannin derives from the Celtic word for OAK TREE which was used for leather processing.	1.93	1

Condition	Relationship Strength	Studies
Encephalitis, Polio [description not available]	2.06	1
Poliomyelitis An acute infectious disease of humans, particularly children, caused by any of three serotypes of human poliovirus (POLIOVIRUS). Usually the infection is limited to the gastrointestinal tract and nasopharynx, and is often asymptomatic. The central nervous system, primarily the spinal cord, may be affected, leading to rapidly progressive paralysis, coarse FASCICULATION and hyporeflexia. Motor neurons are primarily affected. Encephalitis may also occur. The virus replicates in the nervous system, and may cause significant neuronal loss, most notably in the spinal cord. A rare related condition, nonpoliovirus poliomyelitis, may result from infections with nonpoliovirus enteroviruses. (From Adams et al., Principles of Neurology, 6th ed, pp764-5)	2.06	1
Anaphylactic Reaction [description not available]	2.13	1
Delayed Hypersensitivity [description not available]	2.13	1
Anaphylaxis An acute hypersensitivity reaction due to exposure to a previously encountered ANTIGEN. The reaction may include rapidly progressing URTICARIA, respiratory distress, vascular collapse, systemic SHOCK, and death.	2.13	1
Disease Models, Animal Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.	2.06	1
Rhinitis, Allergic, Nonseasonal [description not available]	2.06	1
Rhinitis, Allergic, Perennial Inflammation of the mucous membrane of the nose similar to that found in hay fever except that symptoms persist throughout the year. The causes are usually air-borne allergens, particularly dusts, feathers, molds, animal fur, etc.	2.06	1
Innate Inflammatory Response [description not available]	2.06	1
Inflammation A pathological process characterized by injury or destruction of tissues caused by a variety of cytologic and chemical reactions. It is usually manifested by typical signs of pain, heat, redness, swelling, and loss of function.	2.06	1
Colitis Gravis [description not available]	2.07	1
Weight Reduction [description not available]	2.07	1
Colitis, Ulcerative Inflammation of the COLON that is predominantly confined to the MUCOSA. Its major symptoms include DIARRHEA, rectal BLEEDING, the passage of MUCUS, and ABDOMINAL PAIN.	2.07	1
Weight Loss Decrease in existing BODY WEIGHT.	2.07	1

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