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m8-nelfinavir

Description

M8-nelfinavir: structure in first source [MeSH]

Cross-References

ID SourceID
PubMed CID75213036
MeSH IDM0507663

Synonyms (1)

Synonym
m8-nelfinavir

Research

Studies (7)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's5 (71.43)29.6817
2010's2 (28.57)24.3611
2020's0 (0.00)2.80

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials3 (42.86%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other4 (57.14%)84.16%
SubstanceStudiesClassesRolesFirst YearLast YearAverage AgeRelationship StrengthTrialspre-19901990's2000's2010'spost-2020
carbamatesamino-acid anion2007200717.0low000100
nelfinaviraryl sulfide;
benzamides;
organic heterobicyclic compound;
phenols;
secondary alcohol;
tertiary amino compound
antineoplastic agent;
HIV protease inhibitor
2007201913.9high300520
amprenavircarbamate ester;
sulfonamide;
tetrahydrofuryl ester
antiviral drug;
HIV protease inhibitor
2007200717.0low000100
lopinaviramphetamines;
dicarboxylic acid diamide
anticoronaviral agent;
antiviral drug;
HIV protease inhibitor
2007200717.0low000100
atazanavir sulfateorganic sulfate salt2007200717.0low000100
ritonavir1,3-thiazoles;
carbamate ester;
carboxamide;
L-valine derivative;
ureas
antiviral drug;
environmental contaminant;
HIV protease inhibitor;
xenobiotic
2007200717.0low000100
saquinavirL-asparagine derivative;
quinolines
antiviral drug;
HIV protease inhibitor
2007200717.0low000100
beta carotenecarotenoid beta-end derivative;
cyclic carotene
antioxidant;
biological pigment;
cofactor;
ferroptosis inhibitor;
human metabolite;
mouse metabolite;
plant metabolite;
provitamin A
2012201212.0low100010
indinavir sulfatedicarboxylic acid diamide;
N-(2-hydroxyethyl)piperazine;
piperazinecarboxamide
HIV protease inhibitor2007200717.0low000100
pyrimidinones2007200717.0low000100
ConditionIndicatedStudiesFirst YearLast YearAverage AgeRelationship StrengthTrialspre-19901990's2000's2010'spost-2020
Body Weight02008200816.0low000100
Chronic Hepatitis B02009200915.0low000100
Chronic Hepatitis C02009200915.0low000100
Complications, Infectious Pregnancy0201920195.0low100010
Hepatitis B, Chronic02009200915.0low000100
Hepatitis C, Chronic02009200915.0low000100
HIV Coinfection02007201215.0high100310
HIV Infections02007201215.0high100310
Pregnancy0201920195.0low100010
Sensitivity and Specificity02007200717.0medium000200

Pharmacokinetics (3)

ArticleYear
Pharmacokinetics of Increased Nelfinavir Plasma Concentrations in Women During Pregnancy and Postpartum.
Journal of clinical pharmacology, , Volume: 59, Issue:3
2019
The effect of β-carotene supplementation on the pharmacokinetics of nelfinavir and its active metabolite M8 in HIV-1-infected patients.
Molecules (Basel, Switzerland), , Jan-12, Volume: 17, Issue:1
2012
Influence of CYP2C19 polymorphism on the pharmacokinetics of nelfinavir and its active metabolite.
British journal of clinical pharmacology, , Volume: 68, Issue:5
2009

Bioavailability (1)

ArticleYear
Effect of CYP2C19 polymorphism on nelfinavir to M8 biotransformation in HIV patients.
British journal of clinical pharmacology, , Volume: 65, Issue:4
2008