galphimine a

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

galphimine A: isolated from the Mexican plant Galphimia glauca; structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Flora	Rank	Flora Definition	Family	Family Definition
Galphimia	genus	A plant genus of the family MALPIGHIACEAE. G. glauca is the source of 'Galphimia glauca extract' and contains 'galphimine B' and tetragalloylquinic acid.[MeSH]	Malpighiaceae	A plant family of the order Polygalales, subclass Rosidae class, Magnoliopsida that are mostly shrubs and small trees. Many of the members contain indole alkaloids.[MeSH]

Cross-References

ID Source	ID
PubMed CID	21578020
CHEMBL ID	522335
MeSH ID	M0490527

Synonyms (3)

Synonym
CHEMBL522335
galphimine a
methyl (1s,2r,5s,10s,11s,14s,15s,21r,22r,23s)-10,22,23-trihydroxy-21-[(1r)-1-hydroxyethyl]-2,5,8,14-tetramethyl-18-oxo-19-oxapentacyclo[12.9.0.02,11.05,10.015,21]tricosa-7,16-diene-11-carboxylate

Research Excerpts

Pharmacokinetics

Excerpt	Reference	Relevance
"The aim of this study was to obtain pharmacokinetic data for the anxiolytic compound galphimine-A (G-A) from Galphimia glauca."	( Pharmacokinetic study in mice of galphimine-A, an anxiolytic compound from Galphimia glauca. Abarca Vargas, R; Aguilar, FA; Herrera-Ruiz, M; Jiménez-Ferrer, E; Tortoriello, J; Zamilpa, A, 2014)	0.4

[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (6)

Assay ID	Title	Year	Journal	Article
AID401220	Cytotoxicity against human KB cells	2004	Journal of natural products, Apr, Volume: 67, Issue:4	Isolation of nor-secofriedelanes from the sedative extracts of Galphimia glauca.
AID401222	Cytotoxicity against human OVCAR cells	2004	Journal of natural products, Apr, Volume: 67, Issue:4	Isolation of nor-secofriedelanes from the sedative extracts of Galphimia glauca.
AID401223	Cytotoxicity against human SQC1 cells	2004	Journal of natural products, Apr, Volume: 67, Issue:4	Isolation of nor-secofriedelanes from the sedative extracts of Galphimia glauca.
AID378973	Anxiolytic effect in ICR mouse assessed as increase in number of entries on open arm at 15 mg/kg, ip administered 1 hr before by elevated plus-maze test	2006	Journal of natural products, Jan, Volume: 69, Issue:1	Anxiolytic effect of natural galphimines from Galphimia glauca and their chemical derivatives.
AID401221	Cytotoxicity against human HCT15 cells	2004	Journal of natural products, Apr, Volume: 67, Issue:4	Isolation of nor-secofriedelanes from the sedative extracts of Galphimia glauca.
AID378972	Anxiolytic effect in ICR mouse assessed as increase in time spent on open arm at 15 mg/kg, ip administered 1 hr before by elevated plus-maze test	2006	Journal of natural products, Jan, Volume: 69, Issue:1	Anxiolytic effect of natural galphimines from Galphimia glauca and their chemical derivatives.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (6)

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	4 (66.67)	29.6817
2010's	2 (33.33)	24.3611
2020's	0 (0.00)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.43

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

Metric	This Compound (vs All)
Research Demand Index	12.43 (24.57)
Research Supply Index	1.95 (2.92)
Research Growth Index	4.37 (4.65)
Search Engine Demand Index	0.00 (26.88)
Search Engine Supply Index	0.00 (0.95)

This Compound (12.43)

All Compounds (24.57)

Study Types

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	0 (0.00%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	6 (100.00%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
dimethyl sulfoxide Dimethyl Sulfoxide: A highly polar organic liquid, that is used widely as a chemical solvent. Because of its ability to penetrate biological membranes, it is used as a vehicle for topical application of pharmaceuticals. It is also used to protect tissue during CRYOPRESERVATION. Dimethyl sulfoxide shows a range of pharmacological activity including analgesia and anti-inflammation.. dimethyl sulfoxide : A 2-carbon sulfoxide in which the sulfur atom has two methyl substituents.	2.02	1	sulfoxide; volatile organic compound	alkylating agent; antidote; Escherichia coli metabolite; geroprotector; MRI contrast agent; non-narcotic analgesic; polar aprotic solvent; radical scavenger
diazepam Diazepam: A benzodiazepine with anticonvulsant, anxiolytic, sedative, muscle relaxant, and amnesic properties and a long duration of action. Its actions are mediated by enhancement of GAMMA-AMINOBUTYRIC ACID activity.. diazepam : A 1,4-benzodiazepinone that is 1,3-dihydro-2H-1,4-benzodiazepin-2-one substituted by a chloro group at position 7, a methyl group at position 1 and a phenyl group at position 5.	2.94	1	1,4-benzodiazepinone; organochlorine compound	anticonvulsant; anxiolytic drug; environmental contaminant; sedative; xenobiotic
tetradecanoylphorbol acetate Tetradecanoylphorbol Acetate: A phorbol ester found in CROTON OIL with very effective tumor promoting activity. It stimulates the synthesis of both DNA and RNA.. phorbol ester : Esters of phorbol, originally found in croton oil (from Croton tiglium, of the family Euphorbiaceae). A number of phorbol esters possess activity as tumour promoters and activate the mechanisms associated with cell growth. Some of these are used in experiments as activators of protein kinase C.. phorbol 13-acetate 12-myristate : A phorbol ester that is phorbol in which the hydroxy groups at the cyclopropane ring juction (position 13) and the adjacent carbon (position 12) have been converted into the corresponding acetate and myristate esters. It is a major active constituent of the seed oil of Croton tiglium. It has been used as a tumour promoting agent for skin carcinogenesis in rodents and is associated with increased cell proliferation of malignant cells. However its function is controversial since a decrease in cell proliferation has also been observed in several cancer cell types.	3.01	1	acetate ester; diester; phorbol ester; tertiary alpha-hydroxy ketone; tetradecanoate ester	antineoplastic agent; apoptosis inducer; carcinogenic agent; mitogen; plant metabolite; protein kinase C agonist; reactive oxygen species generator
galphimine b galphimine B: structure given in first source; isolated from the Mexican plant Galphimia glauca, used in traditional medicine	4.33	4
galphimine e galphimine E: isolated from the Mexican plant Galphimia glauca; structure in first source	5.09	5

Condition	Relationship Strength	Studies
Disease Models, Animal Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.	2.94	1
Anasarca [description not available]	3.01	1
Edema Abnormal fluid accumulation in TISSUES or body cavities. Most cases of edema are present under the SKIN in SUBCUTANEOUS TISSUE.	3.01	1
Acute Liver Injury, Drug-Induced [description not available]	2.95	1
Chemical and Drug Induced Liver Injury A spectrum of clinical liver diseases ranging from mild biochemical abnormalities to ACUTE LIVER FAILURE, caused by drugs, drug metabolites, herbal and dietary supplements and chemicals from the environment.	2.95	1

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