galphimine E: isolated from the Mexican plant Galphimia glauca; structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
| Flora | Rank | Flora Definition | Family | Family Definition |
|---|---|---|---|---|
| Galphimia | genus | A plant genus of the family MALPIGHIACEAE. G. glauca is the source of 'Galphimia glauca extract' and contains 'galphimine B' and tetragalloylquinic acid.[MeSH] | Malpighiaceae | A plant family of the order Polygalales, subclass Rosidae class, Magnoliopsida that are mostly shrubs and small trees. Many of the members contain indole alkaloids.[MeSH] |
| ID Source | ID |
|---|---|
| PubMed CID | 21578019 |
| CHEMBL ID | 502176 |
| MeSH ID | M0495861 |
| Synonym |
|---|
| galphimine e |
| CHEMBL502176 |
| methyl (1s,2r,5s,10s,11s,14s,15s,21r,22r,23s)-22-acetyloxy-10,23-dihydroxy-21-[(1r)-1-hydroxyethyl]-2,5,8,14-tetramethyl-18-oxo-19-oxapentacyclo[12.9.0.02,11.05,10.015,21]tricosa-7,16-diene-11-carboxylate |
| Excerpt | Reference | Relevance |
|---|---|---|
| "The aim of this study was to obtain pharmacokinetic data for the anxiolytic compound galphimine-A (G-A) from Galphimia glauca." | ( Pharmacokinetic study in mice of galphimine-A, an anxiolytic compound from Galphimia glauca. Abarca Vargas, R; Aguilar, FA; Herrera-Ruiz, M; Jiménez-Ferrer, E; Tortoriello, J; Zamilpa, A, 2014) | 0.4 |
| Assay ID | Title | Year | Journal | Article |
|---|---|---|---|---|
| AID401223 | Cytotoxicity against human SQC1 cells | 2004 | Journal of natural products, Apr, Volume: 67, Issue:4 | Isolation of nor-secofriedelanes from the sedative extracts of Galphimia glauca. |
| AID401221 | Cytotoxicity against human HCT15 cells | 2004 | Journal of natural products, Apr, Volume: 67, Issue:4 | Isolation of nor-secofriedelanes from the sedative extracts of Galphimia glauca. |
| AID401222 | Cytotoxicity against human OVCAR cells | 2004 | Journal of natural products, Apr, Volume: 67, Issue:4 | Isolation of nor-secofriedelanes from the sedative extracts of Galphimia glauca. |
| AID401220 | Cytotoxicity against human KB cells | 2004 | Journal of natural products, Apr, Volume: 67, Issue:4 | Isolation of nor-secofriedelanes from the sedative extracts of Galphimia glauca. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||||
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 4 (57.14) | 29.6817 |
| 2010's | 2 (28.57) | 24.3611 |
| 2020's | 1 (14.29) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.
| This Compound (12.36) All Compounds (24.57) |
| Publication Type | This drug (%) | All Drugs (%) |
|---|---|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 0 (0.00%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 7 (100.00%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||