dictyoceratin-c and Sarcoma-180

dictyoceratin-c has been researched along with Sarcoma-180* in 1 studies

Other Studies

1 other study(ies) available for dictyoceratin-c and Sarcoma-180

Article	Year
Structure-Activity Relationship and in Vivo Anti-Tumor Evaluations of Dictyoceratin-A and -C, Hypoxia-Selective Growth Inhibitors from Marine Sponge. Marine drugs, 2015, Dec-16, Volume: 13, Issue:12 Oral dictyoceratin-C (1) and A (2), hypoxia-selective growth inhibitors, showed potent in vivo antitumor effects in mice subcutaneously inoculated with sarcoma S180 cells. Structurally modified analogs were synthesized to assess the structure-activity relationship of the natural compounds 1 and 2 isolated from a marine sponge. Biological evaluation of these analogs showed that the exo-olefin and hydroxyl and methyl ester moieties were important for the hypoxia-selective growth inhibitory activities of 1 and 2. Thus far, only substitution of the methyl ester with propargyl amide in 1 was found to be effective for the synthesis of probe molecules for target identification. Topics: Animals; Antineoplastic Agents; Female; Hydroxybenzoates; Mice; Porifera; Sarcoma 180; Sesquiterpenes; Structure-Activity Relationship	2015

Article

Year

Structure-Activity Relationship and in Vivo Anti-Tumor Evaluations of Dictyoceratin-A and -C, Hypoxia-Selective Growth Inhibitors from Marine Sponge.

Marine drugs, 2015, Dec-16, Volume: 13, Issue:12

Oral dictyoceratin-C (1) and A (2), hypoxia-selective growth inhibitors, showed potent in vivo antitumor effects in mice subcutaneously inoculated with sarcoma S180 cells. Structurally modified analogs were synthesized to assess the structure-activity relationship of the natural compounds 1 and 2 isolated from a marine sponge. Biological evaluation of these analogs showed that the exo-olefin and hydroxyl and methyl ester moieties were important for the hypoxia-selective growth inhibitory activities of 1 and 2. Thus far, only substitution of the methyl ester with propargyl amide in 1 was found to be effective for the synthesis of probe molecules for target identification.

Topics: Animals; Antineoplastic Agents; Female; Hydroxybenzoates; Mice; Porifera; Sarcoma 180; Sesquiterpenes; Structure-Activity Relationship

2015