cyclarbamate

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

Cyclarbamate is a cyclic carbamate derivative that has been investigated for its potential therapeutic effects. It has been shown to possess anxiolytic, anticonvulsant, and muscle relaxant properties. However, its clinical use has been limited due to concerns about its safety and efficacy. Cyclarbamate is typically synthesized through a multi-step process involving the reaction of an appropriate amine with a cyclic carbonate. Its mechanism of action is not fully understood, but it is believed to act on the central nervous system, potentially modulating the activity of neurotransmitters such as GABA. Research on cyclarbamate has been focused on exploring its potential therapeutic applications and understanding its pharmacological profile. Despite its limitations, cyclarbamate remains an intriguing compound that warrants further investigation.'

cyclarbamate: structure [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID Source	ID
PubMed CID	72076
CHEMBL ID	2104142
CHEBI ID	135553
SCHEMBL ID	547006
MeSH ID	M0045760

Synonyms (26)

Synonym
5779-54-4
cyclarbamate
CHEBI:135553
[1-(phenylcarbamoyloxymethyl)cyclopentyl]methyl n-phenylcarbamate
cyclopentaphene
CHEMBL2104142
c-1428 ,
cyclarbamatum [inn-latin]
cyclarbamatum
m 906
einecs 227-302-7
ciclarbamato
c 1428
1,1-cyclopentanedimethanol dicarbanilate
unii-779291866j
cyclarbamate [inn:ban:dcf]
779291866j ,
ciclarbamato [inn-spanish]
SCHEMBL547006
cyclarbamate [mi]
cyclarbamate [inn]
cyclarbamat
DTXSID60206480
Q5198119
calmalone; camalon; casmalon; cyclopentaphene
AKOS040751345

[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Drug Classes (1)

Class	Description
carbamate ester	Any ester of carbamic acid or its N-substituted derivatives.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Research

Studies (8)

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	7 (87.50)	18.7374
1990's	0 (0.00)	18.2507
2000's	1 (12.50)	29.6817
2010's	0 (0.00)	24.3611
2020's	0 (0.00)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 11.94

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

Metric	This Compound (vs All)
Research Demand Index	11.94 (24.57)
Research Supply Index	2.20 (2.92)
Research Growth Index	4.14 (4.65)
Search Engine Demand Index	0.00 (26.88)
Search Engine Supply Index	0.00 (0.95)

This Compound (11.94)

All Compounds (24.57)

Study Types

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	0 (0.00%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	8 (100.00%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
carbamates [no description available]	3.44	8	amino-acid anion
diphenhydramine Diphenhydramine: A histamine H1 antagonist used as an antiemetic, antitussive, for dermatoses and pruritus, for hypersensitivity reactions, as a hypnotic, an antiparkinson, and as an ingredient in common cold preparations. It has some undesired antimuscarinic and sedative effects.. diphenhydramine : An ether that is the benzhydryl ether of 2-(dimethylamino)ethanol. It is a H1-receptor antagonist used as a antipruritic and antitussive drug.. antitussive : An agent that suppresses cough. Antitussives have a central or a peripheral action on the cough reflex, or a combination of both. Compare with expectorants, which are considered to increase the volume of secretions in the respiratory tract, so facilitating their removal by ciliary action and coughing, and mucolytics, which decrease the viscosity of mucus, facilitating its removal by ciliary action and expectoration.	1.93	1	ether; tertiary amino compound	anti-allergic agent; antidyskinesia agent; antiemetic; antiparkinson drug; antipruritic drug; antitussive; H1-receptor antagonist; local anaesthetic; muscarinic antagonist; oneirogen; sedative
diphenyl diphenyl: RN given refers to unlabeled cpd; structure	6.93	1	aromatic fungicide; benzenes; biphenyls	antifungal agrochemical; antimicrobial food preservative
cyclopentane Cyclopentanes: A group of alicyclic hydrocarbons with the general formula R-C5H9.. cyclopentanes : Cyclopentane and its derivatives formed by substitution.	2.03	1	cycloalkane; cyclopentanes; volatile organic compound	non-polar solvent
palladium Palladium: A chemical element having an atomic weight of 106.4, atomic number of 46, and the symbol Pd. It is a white, ductile metal resembling platinum, and following it in abundance and importance of applications. It is used in dentistry in the form of gold, silver, and copper alloys.. palladium : Chemical element (nickel group element atom) with atomic number 46.	2.03	1	metal allergen; nickel group element atom; platinum group metal atom
palladium chloride palladium chloride: RN given refers to parent cpd; structure. palladium(II) chloride : A palladium coordination entity consisting of palladium(II) bound to two chlorine atoms.	2.03	1	palladium coordination entity	catalyst
cardiovascular agents Cardiovascular Agents: Agents that affect the rate or intensity of cardiac contraction, blood vessel diameter, or blood volume.	1.94	1

Condition	Relationship Strength	Studies
Depression, Endogenous [description not available]	1.93	1
Pernicious Vomiting of Pregnancy [description not available]	1.93	1
Complications, Pregnancy [description not available]	1.93	1
Puerperal Disorders Disorders or diseases associated with PUERPERIUM, the six-to-eight-week period immediately after PARTURITION in humans.	1.93	1
Depression Depressive states usually of moderate intensity in contrast with MAJOR DEPRESSIVE DISORDER present in neurotic and psychotic disorders.	1.93	1
Depressive Disorder An affective disorder manifested by either a dysphoric mood or loss of interest or pleasure in usual activities. The mood disturbance is prominent and relatively persistent.	1.93	1
Hyperemesis Gravidarum Intractable VOMITING that develops in early PREGNANCY and persists. This can lead to DEHYDRATION and WEIGHT LOSS.	1.93	1
Pregnancy The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.	1.93	1
Rheumatoid Arthritis [description not available]	1.94	1
Back Ache [description not available]	1.94	1
Neuralgia, Sciatic [description not available]	1.94	1
Spinal Diseases Diseases involving the SPINE.	1.94	1
Arthritis, Rheumatoid A chronic systemic disease, primarily of the joints, marked by inflammatory changes in the synovial membranes and articular structures, widespread fibrinoid degeneration of the collagen fibers in mesenchymal tissues, and by atrophy and rarefaction of bony structures. Etiology is unknown, but autoimmune mechanisms have been implicated.	1.94	1
Back Pain Acute or chronic pain located in the posterior regions of the THORAX; LUMBOSACRAL REGION; or the adjacent regions.	1.94	1
Sciatica A condition characterized by pain radiating from the back into the buttock and posterior/lateral aspects of the leg. Sciatica may be a manifestation of SCIATIC NEUROPATHY; RADICULOPATHY (involving the SPINAL NERVE ROOTS; L4, L5, S1, or S2, often associated with INTERVERTEBRAL DISK DISPLACEMENT); or lesions of the CAUDA EQUINA.	1.94	1
Menstruation, Painful [description not available]	1.94	1
Female Genital Diseases [description not available]	1.94	1
Dysmenorrhea Painful menstruation.	1.94	1
Genital Diseases, Female Pathological processes involving the female reproductive tract (GENITALIA, FEMALE).	1.94	1

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