Compounds > cribrostatin 6
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cribrostatin 6

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Description

cribrostatin 6: antineoplastic agent from Cribrochalina species; structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID9903535
CHEMBL ID447648
SCHEMBL ID4821536
MeSH IDM0454285

Synonyms (4)

Synonym
CHEMBL447648
cribrostatin 6
SCHEMBL4821536
9-ethoxy-3,8-dimethylimidazo[5,1-a]isoquinoline-7,10-dione

Research Excerpts

Overview

Cribrostatin 6 is a quinone-containing natural product that induces the death of cancer cell lines in culture. Its mechanism of action and scope of activity are unknown, but it is a promising lead antibiotic for Gram-positive bacteria.

ExcerptReferenceRelevance
"Cribrostatin 6 is a quinone-containing natural product that induces the death of cancer cell lines in culture, and its mechanism of action and scope of activity are unknown. "( Cribrostatin 6 induces death in cancer cells through a reactive oxygen species (ROS)-mediated mechanism.
Hergenrother, PJ; Hoyt, MT; Palchaudhuri, R, 2011)		3.25
"Cribrostatin 6 is a promising lead antibiotic for Gram-positive bacteria, particularly S."( Antibacterial activity of the marine sponge constituent cribrostatin 6.
Cage, GD; Fakoury, BR; Knight, JC; Pettit, GR; Pettit, RK; Pon, S; Weber, CA, 2004)		1.29
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (23)

Assay IDTitleYearJournalArticle
AID355746Antimicrobial activity against Enterobacter cloacae ATCC 13047 by broth microdilution susceptibility assay2003Journal of natural products, Apr, Volume: 66, Issue:4
Antineoplastic agents. 485. Isolation and structure of cribrostatin 6, a dark blue cancer cell growth inhibitor from the marine sponge Cribrochalina sp.
AID355745Antimicrobial activity against Escherichia coli ATCC 25922 by broth microdilution susceptibility assay2003Journal of natural products, Apr, Volume: 66, Issue:4
Antineoplastic agents. 485. Isolation and structure of cribrostatin 6, a dark blue cancer cell growth inhibitor from the marine sponge Cribrochalina sp.
AID355729Growth inhibition of human KM20L2 cells2003Journal of natural products, Apr, Volume: 66, Issue:4
Antineoplastic agents. 485. Isolation and structure of cribrostatin 6, a dark blue cancer cell growth inhibitor from the marine sponge Cribrochalina sp.
AID355747Antimicrobial activity against Neisseria gonorrhoeae ATCC 49226 by broth microdilution susceptibility assay2003Journal of natural products, Apr, Volume: 66, Issue:4
Antineoplastic agents. 485. Isolation and structure of cribrostatin 6, a dark blue cancer cell growth inhibitor from the marine sponge Cribrochalina sp.
AID355731Growth inhibition of mouse P388 cells2003Journal of natural products, Apr, Volume: 66, Issue:4
Antineoplastic agents. 485. Isolation and structure of cribrostatin 6, a dark blue cancer cell growth inhibitor from the marine sponge Cribrochalina sp.
AID355744Antimicrobial activity against Stenotrophomonas maltophilia ATCC 13637 by broth microdilution susceptibility assay2003Journal of natural products, Apr, Volume: 66, Issue:4
Antineoplastic agents. 485. Isolation and structure of cribrostatin 6, a dark blue cancer cell growth inhibitor from the marine sponge Cribrochalina sp.
AID355739Antimicrobial activity against Bacillus subtilis isolate by broth microdilution susceptibility assay2003Journal of natural products, Apr, Volume: 66, Issue:4
Antineoplastic agents. 485. Isolation and structure of cribrostatin 6, a dark blue cancer cell growth inhibitor from the marine sponge Cribrochalina sp.
AID355735Antimicrobial activity against Staphylococcus aureus ATCC 29213 by broth microdilution susceptibility assay2003Journal of natural products, Apr, Volume: 66, Issue:4
Antineoplastic agents. 485. Isolation and structure of cribrostatin 6, a dark blue cancer cell growth inhibitor from the marine sponge Cribrochalina sp.
AID355734Antimicrobial activity against Micrococcus luteus Presque Isle 456 by broth microdilution susceptibility assay2003Journal of natural products, Apr, Volume: 66, Issue:4
Antineoplastic agents. 485. Isolation and structure of cribrostatin 6, a dark blue cancer cell growth inhibitor from the marine sponge Cribrochalina sp.
AID355728Growth inhibition of human NCI-H460 cells2003Journal of natural products, Apr, Volume: 66, Issue:4
Antineoplastic agents. 485. Isolation and structure of cribrostatin 6, a dark blue cancer cell growth inhibitor from the marine sponge Cribrochalina sp.
AID355730Growth inhibition of human DU145 cells2003Journal of natural products, Apr, Volume: 66, Issue:4
Antineoplastic agents. 485. Isolation and structure of cribrostatin 6, a dark blue cancer cell growth inhibitor from the marine sponge Cribrochalina sp.
AID355737Antimicrobial activity against Enterococcus faecalis ATCC 29212 isolate by broth microdilution susceptibility assay2003Journal of natural products, Apr, Volume: 66, Issue:4
Antineoplastic agents. 485. Isolation and structure of cribrostatin 6, a dark blue cancer cell growth inhibitor from the marine sponge Cribrochalina sp.
AID355738Antimicrobial activity against vancomycin-resistant Enterococcus faecalis isolate by broth microdilution susceptibility assay2003Journal of natural products, Apr, Volume: 66, Issue:4
Antineoplastic agents. 485. Isolation and structure of cribrostatin 6, a dark blue cancer cell growth inhibitor from the marine sponge Cribrochalina sp.
AID355736Antimicrobial activity against methicillin-resistant Staphylococcus aureus isolate by broth microdilution susceptibility assay2003Journal of natural products, Apr, Volume: 66, Issue:4
Antineoplastic agents. 485. Isolation and structure of cribrostatin 6, a dark blue cancer cell growth inhibitor from the marine sponge Cribrochalina sp.
AID355732Antimicrobial activity against Candida albicans ATCC 90028 by broth microdilution susceptibility assay2003Journal of natural products, Apr, Volume: 66, Issue:4
Antineoplastic agents. 485. Isolation and structure of cribrostatin 6, a dark blue cancer cell growth inhibitor from the marine sponge Cribrochalina sp.
AID355741Antimicrobial activity against penicillin-resistant Streptococcus pneumoniae isolate by broth microdilution susceptibility assay2003Journal of natural products, Apr, Volume: 66, Issue:4
Antineoplastic agents. 485. Isolation and structure of cribrostatin 6, a dark blue cancer cell growth inhibitor from the marine sponge Cribrochalina sp.
AID355727Growth inhibition of human SF268 cells2003Journal of natural products, Apr, Volume: 66, Issue:4
Antineoplastic agents. 485. Isolation and structure of cribrostatin 6, a dark blue cancer cell growth inhibitor from the marine sponge Cribrochalina sp.
AID355742Antimicrobial activity against Streptococcus pneumoniae isolate by broth microdilution susceptibility assay2003Journal of natural products, Apr, Volume: 66, Issue:4
Antineoplastic agents. 485. Isolation and structure of cribrostatin 6, a dark blue cancer cell growth inhibitor from the marine sponge Cribrochalina sp.
AID355726Growth inhibition of human MCF7 cells2003Journal of natural products, Apr, Volume: 66, Issue:4
Antineoplastic agents. 485. Isolation and structure of cribrostatin 6, a dark blue cancer cell growth inhibitor from the marine sponge Cribrochalina sp.
AID355733Antimicrobial activity against Cryptococcus neoformans ATCC 90112 by broth microdilution susceptibility assay2003Journal of natural products, Apr, Volume: 66, Issue:4
Antineoplastic agents. 485. Isolation and structure of cribrostatin 6, a dark blue cancer cell growth inhibitor from the marine sponge Cribrochalina sp.
AID355740Antimicrobial activity against Streptococcus pneumoniae ATCC 6303 by broth microdilution susceptibility assay2003Journal of natural products, Apr, Volume: 66, Issue:4
Antineoplastic agents. 485. Isolation and structure of cribrostatin 6, a dark blue cancer cell growth inhibitor from the marine sponge Cribrochalina sp.
AID355725Growth inhibition of human BxPC3 cells2003Journal of natural products, Apr, Volume: 66, Issue:4
Antineoplastic agents. 485. Isolation and structure of cribrostatin 6, a dark blue cancer cell growth inhibitor from the marine sponge Cribrochalina sp.
AID355743Antimicrobial activity against Streptococcus isolate by broth microdilution susceptibility assay2003Journal of natural products, Apr, Volume: 66, Issue:4
Antineoplastic agents. 485. Isolation and structure of cribrostatin 6, a dark blue cancer cell growth inhibitor from the marine sponge Cribrochalina sp.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (7)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's4 (57.14)29.6817
2010's3 (42.86)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other7 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
ethidium
Ethidium: A trypanocidal agent and possible antiviral agent that is widely used in experimental cell biology and biochemistry. Ethidium has several experimentally useful properties including binding to nucleic acids, noncompetitive inhibition of nicotinic acetylcholine receptors, and fluorescence among others. It is most commonly used as the bromide.. ethidium : The fluorescent compound widely used in experimental cell biology and biochemistry to reveal double-stranded DNA and RNA.		2.0610phenanthridinesfluorochrome;
intercalator
acetylcysteine
N-acetyl-L-cysteine : An N-acetyl-L-amino acid that is the N-acetylated derivative of the natural amino acid L-cysteine.		2.0610acetylcysteine;
L-cysteine derivative;
N-acetyl-L-amino acid		antidote to paracetamol poisoning;
antiinfective agent;
antioxidant;
antiviral drug;
ferroptosis inhibitor;
geroprotector;
human metabolite;
mucolytic;
radical scavenger;
vulnerary
camptothecin
NSC 100880: carboxylate (opened lactone) form of camptothecin; RN refers to (S)-isomer; structure given in first source		2.0610delta-lactone;
pyranoindolizinoquinoline;
quinoline alkaloid;
tertiary alcohol		antineoplastic agent;
EC 5.99.1.2 (DNA topoisomerase) inhibitor;
genotoxin;
plant metabolite
cyclobutenone
cyclobutenone: structure in first source		7.0610
ConditionIndicatedRelationship StrengthStudiesTrials
Leukemia P388
An experimental lymphocytic leukemia originally induced in DBA/2 mice by painting with methylcholanthrene.		02.0110