cribrostatin-6 and cyclobutenone

cribrostatin-6 has been researched along with cyclobutenone* in 1 studies

Other Studies

1 other study(ies) available for cribrostatin-6 and cyclobutenone

Article	Year
New insights into cyclobutenone rearrangements: a total synthesis of the natural ROS-generating anti-cancer agent cribrostatin 6. Chemistry (Weinheim an der Bergstrasse, Germany), 2011, Dec-02, Volume: 17, Issue:49 Aryl- and heteroarylcyclobutenone rearrangements proceed in excellent yield under continuous-flow conditions. The former shows a Hammett correlation with σ(I) providing strong evidence that electrocyclisation is the rate-determining step and has a late transition state. The reaction has been modelled by using DFT and CCSD(T) methods, with the latter giving excellent correlation with the experimental rate constant. A short and efficient total synthesis of cribrostatin 6, an anti-neoplastic and anti-microbial agent, provides a topical demonstration of the value of this method. Topics: Antineoplastic Agents; Crystallography, X-Ray; Cyclobutanes; Isoquinolines; Molecular Conformation; Molecular Structure; Reactive Oxygen Species	2011

Article

Year

New insights into cyclobutenone rearrangements: a total synthesis of the natural ROS-generating anti-cancer agent cribrostatin 6.

Chemistry (Weinheim an der Bergstrasse, Germany), 2011, Dec-02, Volume: 17, Issue:49

Aryl- and heteroarylcyclobutenone rearrangements proceed in excellent yield under continuous-flow conditions. The former shows a Hammett correlation with σ(I) providing strong evidence that electrocyclisation is the rate-determining step and has a late transition state. The reaction has been modelled by using DFT and CCSD(T) methods, with the latter giving excellent correlation with the experimental rate constant. A short and efficient total synthesis of cribrostatin 6, an anti-neoplastic and anti-microbial agent, provides a topical demonstration of the value of this method.

Topics: Antineoplastic Agents; Crystallography, X-Ray; Cyclobutanes; Isoquinolines; Molecular Conformation; Molecular Structure; Reactive Oxygen Species

2011