Compounds > lycogarubin c
Page last updated: 2024-11-12

lycogarubin c

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

lycogarubin C: structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID11037060
CHEMBL ID371472
SCHEMBL ID12658123
MeSH IDM0546650

Synonyms (6)

Synonym
CHEMBL371472
lycogarubin c
1h-pyrrole-2,5-dicarboxylic acid, 3,4-di-1h-indol-3-yl-, dimethyl ester
150044-77-2
SCHEMBL12658123
DTXSID80452826
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (22)

Assay IDTitleYearJournalArticle
AID243912Inhibition of epidermal growth factor receptor mediated [gamma-32P]-ATP incorporation at 0.1 ug/mL2005Bioorganic & medicinal chemistry letters, Jun-02, Volume: 15, Issue:11
New cytotoxic bisindole alkaloids with protein tyrosine kinase inhibitory activity from a myxomycete Lycogala epidendrum.
AID243790Inhibition of Protein kinase C mediated [gamma-3]-ATP incorporation at 0.1 ug/mL2005Bioorganic & medicinal chemistry letters, Jun-02, Volume: 15, Issue:11
New cytotoxic bisindole alkaloids with protein tyrosine kinase inhibitory activity from a myxomycete Lycogala epidendrum.
AID243906Inhibition of epidermal growth factor receptor mediated [gamma-32P]-ATP incorporation at 1 ug/mL2005Bioorganic & medicinal chemistry letters, Jun-02, Volume: 15, Issue:11
New cytotoxic bisindole alkaloids with protein tyrosine kinase inhibitory activity from a myxomycete Lycogala epidendrum.
AID447681Inhibition of Cy3-labeled mouse recombinant Hes1 (3-281) dimer formation expressed in Escherichia coli at 100 uM by microplate-based assay2009Bioorganic & medicinal chemistry letters, Oct-01, Volume: 19, Issue:19
The first Hes1 dimer inhibitors from natural products.
AID243910Inhibition of epidermal growth factor receptor mediated [gamma-32P]-ATP incorporation at 10 ug/mL2005Bioorganic & medicinal chemistry letters, Jun-02, Volume: 15, Issue:11
New cytotoxic bisindole alkaloids with protein tyrosine kinase inhibitory activity from a myxomycete Lycogala epidendrum.
AID391903Antiviral activity against HSV2008Journal of natural products, Oct, Volume: 71, Issue:10
Lynamicins A-E, chlorinated bisindole pyrrole antibiotics from a novel marine actinomycete.
AID243937Inhibition of eukaryotic elongation factor-2 kinase mediated [gamma-32P]-ATP incorporation at 1 ug/mL2005Bioorganic & medicinal chemistry letters, Jun-02, Volume: 15, Issue:11
New cytotoxic bisindole alkaloids with protein tyrosine kinase inhibitory activity from a myxomycete Lycogala epidendrum.
AID243799Inhibition of Protein kinase A mediated [gamma-32P]-ATP incorporation at 0.1 ug/mL2005Bioorganic & medicinal chemistry letters, Jun-02, Volume: 15, Issue:11
New cytotoxic bisindole alkaloids with protein tyrosine kinase inhibitory activity from a myxomycete Lycogala epidendrum.
AID243770Inhibition of Protein kinase C mediated [gamma-3]-ATP incorporation at 1 ug/mL2005Bioorganic & medicinal chemistry letters, Jun-02, Volume: 15, Issue:11
New cytotoxic bisindole alkaloids with protein tyrosine kinase inhibitory activity from a myxomycete Lycogala epidendrum.
AID243936Inhibition of eukaryotic elongation factor-2 kinase mediated [gamma-32P]-ATP incorporation at 10 ug/mL2005Bioorganic & medicinal chemistry letters, Jun-02, Volume: 15, Issue:11
New cytotoxic bisindole alkaloids with protein tyrosine kinase inhibitory activity from a myxomycete Lycogala epidendrum.
AID247488Cytotoxicity against KB/VJ300 cells2005Bioorganic & medicinal chemistry letters, Jun-02, Volume: 15, Issue:11
New cytotoxic bisindole alkaloids with protein tyrosine kinase inhibitory activity from a myxomycete Lycogala epidendrum.
AID243956Inhibition of Vascular endothelial growth factor receptor 1 mediated [gamma-32P]-ATP incorporation at 1 ug/mL2005Bioorganic & medicinal chemistry letters, Jun-02, Volume: 15, Issue:11
New cytotoxic bisindole alkaloids with protein tyrosine kinase inhibitory activity from a myxomycete Lycogala epidendrum.
AID243789Inhibition of Protein kinase A mediated [gamma-32P]-ATP incorporation at 10 ug/mL2005Bioorganic & medicinal chemistry letters, Jun-02, Volume: 15, Issue:11
New cytotoxic bisindole alkaloids with protein tyrosine kinase inhibitory activity from a myxomycete Lycogala epidendrum.
AID243961Inhibition of Vascular endothelial growth factor receptor 1 mediated [gamma-32P]-ATP incorporation at 0.1 ug/mL2005Bioorganic & medicinal chemistry letters, Jun-02, Volume: 15, Issue:11
New cytotoxic bisindole alkaloids with protein tyrosine kinase inhibitory activity from a myxomycete Lycogala epidendrum.
AID243780Inhibition of Protein kinase C mediated [gamma-3]-ATP incorporation at 10 ug/mL2005Bioorganic & medicinal chemistry letters, Jun-02, Volume: 15, Issue:11
New cytotoxic bisindole alkaloids with protein tyrosine kinase inhibitory activity from a myxomycete Lycogala epidendrum.
AID243839Inhibition of protein tyrosine kinase mediated [gamma-32P]-ATP incorporation at 1 ug/mL in src-transformed NIH3T32005Bioorganic & medicinal chemistry letters, Jun-02, Volume: 15, Issue:11
New cytotoxic bisindole alkaloids with protein tyrosine kinase inhibitory activity from a myxomycete Lycogala epidendrum.
AID243845Inhibition of protein tyrosine kinase mediated [gamma-32P]-ATP incorporation at 10 ug/mL in src-transformed NIH3T32005Bioorganic & medicinal chemistry letters, Jun-02, Volume: 15, Issue:11
New cytotoxic bisindole alkaloids with protein tyrosine kinase inhibitory activity from a myxomycete Lycogala epidendrum.
AID243959Inhibition of Vascular endothelial growth factor receptor 1 mediated [gamma-32P]-ATP incorporation at 10 ug/mL2005Bioorganic & medicinal chemistry letters, Jun-02, Volume: 15, Issue:11
New cytotoxic bisindole alkaloids with protein tyrosine kinase inhibitory activity from a myxomycete Lycogala epidendrum.
AID243945Inhibition of eukaryotic elongation factor-2 kinase mediated [gamma-32P]-ATP incorporation at 0.1 ug/mL2005Bioorganic & medicinal chemistry letters, Jun-02, Volume: 15, Issue:11
New cytotoxic bisindole alkaloids with protein tyrosine kinase inhibitory activity from a myxomycete Lycogala epidendrum.
AID243779Inhibition of Protein kinase A mediated [gamma-32P]-ATP incorporation at 1 ug/mL2005Bioorganic & medicinal chemistry letters, Jun-02, Volume: 15, Issue:11
New cytotoxic bisindole alkaloids with protein tyrosine kinase inhibitory activity from a myxomycete Lycogala epidendrum.
AID243853Inhibition of protein tyrosine kinase mediated [gamma-32P]-ATP incorporation at 0.1 ug/mL in src-transformed NIH3T32005Bioorganic & medicinal chemistry letters, Jun-02, Volume: 15, Issue:11
New cytotoxic bisindole alkaloids with protein tyrosine kinase inhibitory activity from a myxomycete Lycogala epidendrum.
AID247475Cytotoxicity against Jurkat cells2005Bioorganic & medicinal chemistry letters, Jun-02, Volume: 15, Issue:11
New cytotoxic bisindole alkaloids with protein tyrosine kinase inhibitory activity from a myxomycete Lycogala epidendrum.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (5)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's3 (60.00)29.6817
2010's2 (40.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.50

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.50 (24.57)
Research Supply Index1.79 (2.92)
Research Growth Index4.30 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.50)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other5 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
bisindolylmaleimide iv
[no description available]		2.0210indoles;
maleimides
staurosporine aglycone
staurosporine aglycone: metabolite from culture broth of Nocardiopsis sp.; a neurotrophin antag; inhibits BDNF TrkB receptor		2.0510
pyrroles
1H-pyrrole : A tautomer of pyrrole that has the double bonds at positions 2 and 4.. pyrrole : A five-membered monocyclic heteroarene comprising one NH and four CH units which forms the parent compound of the pyrrole group of compounds. Its five-membered ring structure has three tautomers. A 'closed class'.. azole : Any monocyclic heteroarene consisting of a five-membered ring containing nitrogen. Azoles can also contain one or more other non-carbon atoms, such as nitrogen, sulfur or oxygen.		2.4820pyrrole;
secondary amine
manganese
Manganese: A trace element with atomic symbol Mn, atomic number 25, and atomic weight 54.94. It is concentrated in cell mitochondria, mostly in the pituitary gland, liver, pancreas, kidney, and bone, influences the synthesis of mucopolysaccharides, stimulates hepatic synthesis of cholesterol and fatty acids, and is a cofactor in many enzymes, including arginase and alkaline phosphatase in the liver. (From AMA Drug Evaluations Annual 1992, p2035). manganese(4+) : A manganese cation that is monoatomic and has a formal charge of +4.		2.110elemental manganese;
manganese group element atom		Escherichia coli metabolite;
micronutrient
chromopyrrolic acid
chromopyrrolic acid: structure in first source. chromopyrrolic acid : A pyrroledicarboxylic acid that is pyrrole-2,5-dicarboxylic acid in which the hydrogens at positions 3 and 4 have been replaced by indol-3-yl groups.		7.9740indoles;
pyrroledicarboxylic acid		bacterial metabolite
lyoniside
lyoniside: see also eleutherosides & syringin for eleutheroside B: 118-34-3; RN given refers to (3beta)-isomer		2.0510
ConditionIndicatedRelationship StrengthStudiesTrials