Page last updated: 2024-11-05
cembrane
Description
Cembrane is a naturally occurring diterpene with a 14-membered macrocyclic ring system. It is found in various marine organisms, including soft corals, sponges, and algae. Cembrane derivatives exhibit diverse biological activities, including anti-inflammatory, anti-cancer, and anti-microbial properties.
The synthesis of cembranes has been extensively studied, with various methods developed to access these complex molecules.
Researchers are interested in cembranes due to their potential applications in medicine and other fields. For example, some cembranes have shown promising activity against various cancer cell lines, while others have demonstrated anti-inflammatory effects. The study of cembranes continues to be an active area of research, with efforts focused on understanding their biosynthesis, exploring their biological activities, and developing new synthetic methods for their production.'
cembrane: diterpene with Ca-antagonistic action on rabbit aorta from soft coral of genus Sarcophyton; structure given in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
cembrane : A 14-membered macrocyclic diterpene carrying an isopropyl group at C-1 and three symmetrically disposed methyl groups at C-4, -8 and -12. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]
Cross-References
| ID Source | ID |
|---|
| PubMed CID | 15702 |
| CHEBI ID | 60689 |
| MeSH ID | M0112427 |
Synonyms (14)
| Synonym |
|---|
| cembrane i |
| cyclotetradecane, 1,7,11-trimethyl-4-(1-methylethyl)- |
| cembrane |
| 1,7,11-trimethyl-4-propan-2-ylcyclotetradecane |
| CHEBI:60689 |
| 1,7,11-trimethyl-4-(propan-2-yl)cyclotetradecane |
| 1786-12-5 |
| LHORCXXUZJAMPU-UHFFFAOYSA-N |
| cyclotetradecane, 4-isopropyl-1,7,11-trimethyl- |
| cembrene, octahydro- |
| 4-isopropyl-1,7,11-trimethylcyclotetradecane # |
| 1,7,11-trimethyl-4-(1-methylethyl)cyclotetradecane |
| DTXSID20873056 |
| Q27128428 |
Drug Classes (1)
| Class | Description |
|---|
| diterpene | A C20 terpene. |
| [compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res] |
Research
Studies (46)
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|
| pre-1990 | 1 (2.17) | 18.7374 |
| 1990's | 3 (6.52) | 18.2507 |
| 2000's | 8 (17.39) | 29.6817 |
| 2010's | 27 (58.70) | 24.3611 |
| 2020's | 7 (15.22) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] |
Market Indicators
Research Demand Index: 38.20
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be strong demand-to-supply ratio for research on this compound.
| Metric | This Compound (vs All) |
|---|
| Research Demand Index | 38.20 (24.57) | | Research Supply Index | 3.85 (2.92) | | Research Growth Index | 5.31 (4.65) | | Search Engine Demand Index | 53.49 (26.88) | | Search Engine Supply Index | 2.00 (0.95) |
| |
Study Types
| Publication Type | This drug (%) | All Drugs (%) |
|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 2 (4.35%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 44 (95.65%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] |