Page last updated: 2024-11-12

cacospongionolide b

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

cacospongionolide B: isolated from the sponge Fasciospongia cavernosa; structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID10386285
CHEMBL ID111739
MeSH IDM0258438

Synonyms (4)

Synonym
cacospongionolide b
CHEMBL111739
bdbm50377908
3-[5-[2-[(1r,2r,4as,8as)-1,2,4a-trimethyl-5-methylidene-3,4,6,7,8,8a-hexahydro-2h-naphthalen-1-yl]ethyl]-3,6-dihydro-2h-pyran-2-yl]-2-hydroxy-2h-furan-5-one

Research Excerpts

Overview

Cacospongionolide B is a novel marine metabolite isolated from the sponge Fasciospongia cavernosa.

ExcerptReferenceRelevance
"1. Cacospongionolide B is a novel marine metabolite isolated from the sponge Fasciospongia cavernosa. "( Modulation of acute and chronic inflammatory processes by cacospongionolide B, a novel inhibitor of human synovial phospholipase A2.
Alcaraz, MJ; De Giulio, A; De Rosa, S; García Pastor, P; Payá, M, 1999
)
1.17
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Protein Targets (3)

Inhibition Measurements

ProteinTaxonomyMeasurementAverageMin (ref.)Avg (ref.)Max (ref.)Bioassay(s)
Phospholipase A2Apis mellifera (honey bee)IC50 (µMol)35.40000.07003.85707.5000AID401446
Phospholipase A2, membrane associatedRattus norvegicus (Norway rat)IC50 (µMol)36.90000.12000.12000.1200AID401444
Phospholipase A2, membrane associatedHomo sapiens (human)IC50 (µMol)45.50000.00301.08118.0000AID401442; AID401443
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Biological Processes (16)

Processvia Protein(s)Taxonomy
phospholipid metabolic processPhospholipase A2, membrane associatedHomo sapiens (human)
inflammatory responsePhospholipase A2, membrane associatedHomo sapiens (human)
positive regulation of macrophage derived foam cell differentiationPhospholipase A2, membrane associatedHomo sapiens (human)
lipid catabolic processPhospholipase A2, membrane associatedHomo sapiens (human)
killing of cells of another organismPhospholipase A2, membrane associatedHomo sapiens (human)
low-density lipoprotein particle remodelingPhospholipase A2, membrane associatedHomo sapiens (human)
intestinal stem cell homeostasisPhospholipase A2, membrane associatedHomo sapiens (human)
phosphatidylethanolamine metabolic processPhospholipase A2, membrane associatedHomo sapiens (human)
phosphatidylcholine metabolic processPhospholipase A2, membrane associatedHomo sapiens (human)
phosphatidic acid metabolic processPhospholipase A2, membrane associatedHomo sapiens (human)
arachidonic acid secretionPhospholipase A2, membrane associatedHomo sapiens (human)
positive regulation of inflammatory responsePhospholipase A2, membrane associatedHomo sapiens (human)
defense response to Gram-positive bacteriumPhospholipase A2, membrane associatedHomo sapiens (human)
positive regulation of ERK1 and ERK2 cascadePhospholipase A2, membrane associatedHomo sapiens (human)
regulation of neutrophil activationPhospholipase A2, membrane associatedHomo sapiens (human)
negative regulation of T cell proliferationPhospholipase A2, membrane associatedHomo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Molecular Functions (4)

Processvia Protein(s)Taxonomy
phospholipase A2 activityPhospholipase A2, membrane associatedHomo sapiens (human)
phospholipid bindingPhospholipase A2, membrane associatedHomo sapiens (human)
calcium-dependent phospholipase A2 activityPhospholipase A2, membrane associatedHomo sapiens (human)
calcium ion bindingPhospholipase A2, membrane associatedHomo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Ceullar Components (9)

Processvia Protein(s)Taxonomy
extracellular regionPhospholipase A2, membrane associatedHomo sapiens (human)
extracellular spacePhospholipase A2, membrane associatedHomo sapiens (human)
mitochondrial outer membranePhospholipase A2, membrane associatedHomo sapiens (human)
endoplasmic reticulumPhospholipase A2, membrane associatedHomo sapiens (human)
endoplasmic reticulum membranePhospholipase A2, membrane associatedHomo sapiens (human)
plasma membranePhospholipase A2, membrane associatedHomo sapiens (human)
secretory granulePhospholipase A2, membrane associatedHomo sapiens (human)
perinuclear region of cytoplasmPhospholipase A2, membrane associatedHomo sapiens (human)
extracellular exosomePhospholipase A2, membrane associatedHomo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Bioassays (22)

Assay IDTitleYearJournalArticle
AID360513Antimicrobial activity against Bacillus subtilis DSM 3471995Journal of natural products, Nov, Volume: 58, Issue:11
Cacospongionolide B, a new sesterterpene from the sponge Fasciospongia cavernosa.
AID158778Inhibitory activity against bee secretory Phospholipase A2 enzyme when pre-incubated with Tris buffer for 5 minutes1998Journal of medicinal chemistry, Aug-13, Volume: 41, Issue:17
Synthesis and comparison of the antiinflammatory activity of manoalide and cacospongionolide B analogues.
AID158772Inhibitory activity against bee secretory Phospholipase A2 enzyme when pre-incubated for 5 minutes1998Journal of medicinal chemistry, Aug-13, Volume: 41, Issue:17
Synthesis and comparison of the antiinflammatory activity of manoalide and cacospongionolide B analogues.
AID401444Inhibition of rat air pouch group2 sPLA2 at 10 uM by liquid scintillation counting1998Journal of natural products, Jul, Volume: 61, Issue:7
A new cacospongionolide inhibitor of human secretory phospholipase A2 from the Tyrrhenian sponge Fasciospongia cavernosa and absolute configuration of cacospongionolides.
AID401443Inhibition of human synovial group2 sPLA2 by liquid scintillation counting1998Journal of natural products, Jul, Volume: 61, Issue:7
A new cacospongionolide inhibitor of human secretory phospholipase A2 from the Tyrrhenian sponge Fasciospongia cavernosa and absolute configuration of cacospongionolides.
AID401442Inhibition of human synovial group2 sPLA2 at 10 uM by liquid scintillation counting1998Journal of natural products, Jul, Volume: 61, Issue:7
A new cacospongionolide inhibitor of human secretory phospholipase A2 from the Tyrrhenian sponge Fasciospongia cavernosa and absolute configuration of cacospongionolides.
AID158771Inhibitory activity against bee secretory Phospholipase A2 enzyme when pre-incubated for 15 minutes1998Journal of medicinal chemistry, Aug-13, Volume: 41, Issue:17
Synthesis and comparison of the antiinflammatory activity of manoalide and cacospongionolide B analogues.
AID401448Cytotoxicity against human neutrophils by MTT assay1998Journal of natural products, Jul, Volume: 61, Issue:7
A new cacospongionolide inhibitor of human secretory phospholipase A2 from the Tyrrhenian sponge Fasciospongia cavernosa and absolute configuration of cacospongionolides.
AID401439Inhibition of Naja naja venom group1 sPLA2 at 10 uM by liquid scintillation counting1998Journal of natural products, Jul, Volume: 61, Issue:7
A new cacospongionolide inhibitor of human secretory phospholipase A2 from the Tyrrhenian sponge Fasciospongia cavernosa and absolute configuration of cacospongionolides.
AID158776Inhibitory activity against bee secretory Phospholipase A2 enzyme when pre-incubated with Hydroxylamine for 60 minutes1998Journal of medicinal chemistry, Aug-13, Volume: 41, Issue:17
Synthesis and comparison of the antiinflammatory activity of manoalide and cacospongionolide B analogues.
AID158773Inhibitory activity against bee secretory Phospholipase A2 enzyme when pre-incubated for 60 minutes1998Journal of medicinal chemistry, Aug-13, Volume: 41, Issue:17
Synthesis and comparison of the antiinflammatory activity of manoalide and cacospongionolide B analogues.
AID401446Inhibition of bee venom group3 sPLA2 at 10 uM by liquid scintillation counting1998Journal of natural products, Jul, Volume: 61, Issue:7
A new cacospongionolide inhibitor of human secretory phospholipase A2 from the Tyrrhenian sponge Fasciospongia cavernosa and absolute configuration of cacospongionolides.
AID360512Toxicity against Artemia salina1995Journal of natural products, Nov, Volume: 58, Issue:11
Cacospongionolide B, a new sesterterpene from the sponge Fasciospongia cavernosa.
AID158775Inhibitory activity against bee secretory Phospholipase A2 enzyme when pre-incubated with Hydroxylamine for 5 minutes1998Journal of medicinal chemistry, Aug-13, Volume: 41, Issue:17
Synthesis and comparison of the antiinflammatory activity of manoalide and cacospongionolide B analogues.
AID158774Inhibitory activity against bee secretory Phospholipase A2 enzyme when pre-incubated with Hydroxylamine for 15 minutes1998Journal of medicinal chemistry, Aug-13, Volume: 41, Issue:17
Synthesis and comparison of the antiinflammatory activity of manoalide and cacospongionolide B analogues.
AID158777Inhibitory activity against bee secretory Phospholipase A2 enzyme when pre-incubated with Tris buffer for 15 minutes1998Journal of medicinal chemistry, Aug-13, Volume: 41, Issue:17
Synthesis and comparison of the antiinflammatory activity of manoalide and cacospongionolide B analogues.
AID401447Inhibition of bee venom group3 sPLA2 by liquid scintillation counting1998Journal of natural products, Jul, Volume: 61, Issue:7
A new cacospongionolide inhibitor of human secretory phospholipase A2 from the Tyrrhenian sponge Fasciospongia cavernosa and absolute configuration of cacospongionolides.
AID401441Inhibition of pig pancreatic group1 sPLA2 by liquid scintillation counting1998Journal of natural products, Jul, Volume: 61, Issue:7
A new cacospongionolide inhibitor of human secretory phospholipase A2 from the Tyrrhenian sponge Fasciospongia cavernosa and absolute configuration of cacospongionolides.
AID158779Inhibitory activity against bee secretory Phospholipase A2 enzyme when pre-incubated with Tris buffer for 60 minutes1998Journal of medicinal chemistry, Aug-13, Volume: 41, Issue:17
Synthesis and comparison of the antiinflammatory activity of manoalide and cacospongionolide B analogues.
AID401445Inhibition of rat air pouch group2 sPLA2 by liquid scintillation counting1998Journal of natural products, Jul, Volume: 61, Issue:7
A new cacospongionolide inhibitor of human secretory phospholipase A2 from the Tyrrhenian sponge Fasciospongia cavernosa and absolute configuration of cacospongionolides.
AID401440Inhibition of pig pancreatic group1 sPLA2 at 10 uM by liquid scintillation counting1998Journal of natural products, Jul, Volume: 61, Issue:7
A new cacospongionolide inhibitor of human secretory phospholipase A2 from the Tyrrhenian sponge Fasciospongia cavernosa and absolute configuration of cacospongionolides.
AID360514Antimicrobial activity against Micrococcus luteus DSM 3481995Journal of natural products, Nov, Volume: 58, Issue:11
Cacospongionolide B, a new sesterterpene from the sponge Fasciospongia cavernosa.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (10)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's5 (50.00)18.2507
2000's4 (40.00)29.6817
2010's1 (10.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 11.86

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index11.86 (24.57)
Research Supply Index2.40 (2.92)
Research Growth Index4.25 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (11.86)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other10 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]