Compounds > butonate
Page last updated: 2024-11-05

butonate

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

butonate: structure [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID31343
CHEMBL ID1570266
CHEBI ID82106
SCHEMBL ID117990
MeSH IDM0049642

Synonyms (88)

Synonym
brn 1813429
o,o-dimethyl-(1-n-butyryloxy-2,2,2-trichloraethyl)-phosphonsaeureester
dimethyl 2,2,2-trichloro-1-n-butyryloxyethylphosphonate
einecs 204-778-4
o,o-dimethyl-2,2,2-trichloro-1-phosphonoethyl butyrate
butonate [iso]
pedix-butonate
dimethyl (2,2,2-trichloro-1-butyryloxyethyl)phosphonate
fekama at 50
butonatum [inn-latin]
dimethyl 1-butyryloxy-2,2,2-trichloroethylphosphonate
butyric acid, ester with dimethyl (2,2,2-trichloro-1-hydroxyethyl)phosphonate
nsc 17872
epa pesticide chemical code 035701
butonato [inn-spanish]
phosphonic acid, (2,2,2-trichloro-1-hydroxyethyl)-, dimethyl ester, butyrate
ent 20,852
o,o-dimethyl-(1-butyryloxy-2,2,2-trichloroethyl) phosphonate
2,2,2-trichloro-1-(dimethoxyphosphinyl)ethyl butanoate
butonat [german]
pedix pe 50
o,o-dimethyl-2,2,2-trichloro-1-n-butyryloxyethyl phosphonate
dimethyl (2,2,2-trichloro-1-hydroxyethyl)phosphonate butyric acid ester
o,o-dimethyl (2,2,2-trichloro-1-n-butyryloxyethyl)phosphonate
o,o-dimethyl (2,2,2-trichloro-1-hydroxyethyl) phosphonate ester of butyric acid
caswell no. 385a
f 139
pedix-50
dimethoxy-2,2,2-trichloro-1-n-butyryloxy-ethylphospine oxide
hsdb 1595
ai3-20852
D03194
butonate (usan/inn)
butanoic acid,2,2-trichloro-1-(dimethoxyphosphinyl)ethyl ester
dimethyl (2,2-trichloro-1-hydroxyethyl)phosphonate ester of butyric acid
dimethoxy-2,2-trichloro-1-n-butyryloxy-ethylphosphine oxide
butyric acid,2,2-trichloro-1-hydroxyethyl)phosphonate
ent-20852
butonate
o,2,2-trichloro-1-n-butyryloxyethyl)phosphonate
0,2,2-trichloro-1-(n-butyryloxy)ethylphosphonate
butyric acid ester of dimethyl (2,2-trichloro-1-hydroxyethyl)phosphonate
tribufon
butanoic acid 2,2-trichloro-1-(dimethoxyphosphinyl)ethyl ester
phosphonic acid,2,2-trichloro-1-hydroxyethyl)-, dimethyl ester, butyrate
126-22-7
wln: gxggyov3 & po & o1 & o1
f-139
dimethyl 2,2-trichloro-1-n-butyryloxyethylphosphonate
nsc-17872
t-113 ,
dimethyl 2,2-trichloro-1-butyryloxyethylphosphonate
butilchlorofos
nsc17872
(2,2,2-trichloro-1-dimethoxyphosphoryl-ethyl) butanoate
BUT ,
butanoic acid, 2,2,2-trichloro-1-(dimethoxyphosphinyl)ethyl ester
2,2,2-trichloro-1-(dimethoxyphosphoryl)ethyl butyrate
0, 0-dimethyl 2,2,2-trichloro-1-(n-butyryloxy)ethylphosphonate
butanoic acid 2,2,2-trichloro-1-(dimethoxyphosphinyl)ethyl ester
NCGC00160570-01
(2,2,2-trichloro-1-dimethoxyphosphorylethyl) butanoate
butonato
unii-39m9r3q494
butonat
39m9r3q494 ,
butonate [usan:inn]
butonatum
C18967
dtxcid3021697
cas-126-22-7
tox21_111908
dtxsid5041697 ,
AKOS024332382
trichlorfon butanoic acid ester
chebi:82106 ,
CHEMBL1570266
SCHEMBL117990
butonate [hsdb]
butonate [inn]
(rs)-2,2,2-trichloro-1-(dimethoxyphosphinoyl)ethyl butyrate
butonate [usan]
trichlorfon butanoic acid ester [mi]
butonate [green book]
BKAQXYNWONVOAX-UHFFFAOYSA-N
Q27155753
DB11379
o,o-dimethyl 2,2,2-trichloro-1-butyryloxyethylphosphonate

Research Excerpts

Bioavailability

ExcerptReferenceRelevance
"The ATP-binding cassette transporter P-glycoprotein (P-gp) is known to limit both brain penetration and oral bioavailability of many chemotherapy drugs."( A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein.
Ambudkar, SV; Brimacombe, KR; Chen, L; Gottesman, MM; Guha, R; Hall, MD; Klumpp-Thomas, C; Lee, OW; Lee, TD; Lusvarghi, S; Robey, RW; Shen, M; Tebase, BG, 2019)		0.51
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Drug Classes (2)

ClassDescription
fatty acid esterA carboxylic ester in which the carboxylic acid component can be any fatty acid.
butyrate esterAny carboxylic ester where the carboxylic acid component is butyric acid.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Protein Targets (8)

Potency Measurements

ProteinTaxonomyMeasurementAverage (µ)Min (ref.)Avg (ref.)Max (ref.)Bioassay(s)
GLS proteinHomo sapiens (human)Potency35.48130.35487.935539.8107AID624170
TDP1 proteinHomo sapiens (human)Potency0.11890.000811.382244.6684AID686979
AR proteinHomo sapiens (human)Potency20.75100.000221.22318,912.5098AID743040; AID743053
estrogen nuclear receptor alphaHomo sapiens (human)Potency16.63070.000229.305416,493.5996AID743069; AID743075; AID743079; AID743080; AID743091
aryl hydrocarbon receptorHomo sapiens (human)Potency33.49150.000723.06741,258.9301AID743085; AID743122
nuclear receptor ROR-gamma isoform 1Mus musculus (house mouse)Potency0.00630.00798.23321,122.0200AID2551
lamin isoform A-delta10Homo sapiens (human)Potency35.48130.891312.067628.1838AID1487
Spike glycoproteinSevere acute respiratory syndrome-related coronavirusPotency63.09570.009610.525035.4813AID1479145
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Ceullar Components (1)

Processvia Protein(s)Taxonomy
virion membraneSpike glycoproteinSevere acute respiratory syndrome-related coronavirus
[Information is prepared from geneontology information from the June-17-2024 release]

Bioassays (4)

Assay IDTitleYearJournalArticle
AID504749qHTS profiling for inhibitors of Plasmodium falciparum proliferation2011Science (New York, N.Y.), Aug-05, Volume: 333, Issue:6043
Chemical genomic profiling for antimalarial therapies, response signatures, and molecular targets.
AID1296008Cytotoxic Profiling of Annotated Libraries Using Quantitative High-Throughput Screening2020SLAS discovery : advancing life sciences R & D, 01, Volume: 25, Issue:1
Cytotoxic Profiling of Annotated and Diverse Chemical Libraries Using Quantitative High-Throughput Screening.
AID1346987P-glycoprotein substrates identified in KB-8-5-11 adenocarcinoma cell line, qHTS therapeutic library screen2019Molecular pharmacology, 11, Volume: 96, Issue:5
A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein.
AID1346986P-glycoprotein substrates identified in KB-3-1 adenocarcinoma cell line, qHTS therapeutic library screen2019Molecular pharmacology, 11, Volume: 96, Issue:5
A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (11)

TimeframeStudies, This Drug (%)All Drugs %
pre-19907 (63.64)18.7374
1990's0 (0.00)18.2507
2000's1 (9.09)29.6817
2010's2 (18.18)24.3611
2020's1 (9.09)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 46.93

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be strong demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index46.93 (24.57)
Research Supply Index2.48 (2.92)
Research Growth Index4.80 (4.65)
Search Engine Demand Index138.47 (26.88)
Search Engine Supply Index4.00 (0.95)

This Compound (46.93)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other11 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
chlorpyrifos
Chlorpyrifos: An organothiophosphate cholinesterase inhibitor that is used as an insecticide and as an acaricide.. chlorpyrifos : An organic thiophosphate that is O,O-diethyl hydrogen phosphorothioate in which the hydrogen of the hydroxy group has been replaced by a 3,5,6-trichloropyridin-2-yl group.		2.0110chloropyridine;
organic thiophosphate		acaricide;
agrochemical;
EC 3.1.1.7 (acetylcholinesterase) inhibitor;
EC 3.1.1.8 (cholinesterase) inhibitor;
environmental contaminant;
insecticide;
xenobiotic
dichlorvos
Dichlorvos: An organophosphorus insecticide that inhibits ACETYLCHOLINESTERASE.. dichlorvos : An alkenyl phosphate that is the 2,2-dichloroethenyl ester of dimethyl phosphate.		8.0550alkenyl phosphate;
dialkyl phosphate;
organochlorine acaricide;
organophosphate insecticide		anthelminthic drug;
antibacterial agent;
antifungal agent;
EC 3.1.1.7 (acetylcholinesterase) inhibitor;
EC 3.1.1.8 (cholinesterase) inhibitor
naled
Naled: An organophosphate cholinesterase inhibitor that is used as an insecticide and as an acaricide.. naled : An dialkyl phosphate resulting from the formal condensation of the acidic hydroxy group of dimethyl hydrogen phosphate with the alcoholic hydroxy group of 1,2-dibromo-2,2-dichloroethanol. An organophosphate insecticide, it is no longer approved for use within the European Union.		2.3620dialkyl phosphate;
organobromine compound;
organochlorine compound;
organophosphate insecticide		acaricide;
agrochemical;
antibacterial agent;
antifungal agent;
EC 3.1.1.7 (acetylcholinesterase) inhibitor;
EC 3.1.1.8 (cholinesterase) inhibitor
trichlorfon
Trichlorfon: An organochlorophosphate cholinesterase inhibitor that is used as an insecticide for the control of flies and roaches. It is also used in anthelmintic compositions for animals. (From Merck, 11th ed). trichlorfon : A phosphonic ester that is dimethyl phosphonate in which the hydrogen atom attched to the phosphorous is substituted by a 2,2,2-trichloro-1-hydroxyethyl group.		8.0550organic phosphonate;
organochlorine compound;
phosphonic ester		agrochemical;
anthelminthic drug;
EC 3.1.1.7 (acetylcholinesterase) inhibitor;
EC 3.1.1.8 (cholinesterase) inhibitor;
insecticide
carbaryl
Carbaryl: A carbamate insecticide and parasiticide. It is a potent anticholinesterase agent belonging to the carbamate group of reversible cholinesterase inhibitors. It has a particularly low toxicity from dermal absorption and is used for control of head lice in some countries.. carbaryl : A carbamate ester obtained by the formal condensation of 1-naphthol with methylcarbamic acid.		1.9510carbamate ester;
naphthalenes		acaricide;
agrochemical;
carbamate insecticide;
EC 3.1.1.7 (acetylcholinesterase) inhibitor;
EC 3.1.1.8 (cholinesterase) inhibitor;
plant growth retardant
o,o-diethyl o-3,5,6-trichloro-2-pyridyl phosphate
[no description available]		2.0110
rafoxanide
Rafoxanide: Veterinary anthelmintic for grazing animals; used to treat fluke, hookworm and other infestations.		1.9510
organophosphonates
hydrogenphosphite : A divalent inorganic anion resulting from the removal of a proton from two of the hydroxy groups of phosphorous acid.		3.4680divalent inorganic anion;
phosphite ion
cp 55244
CP 55244: RN given refers to the (2alpha,4abeta,6alpha,8alpha,8aalpha)-(+-)-isomer; RN for cpd without isomeric designation not avail 9/90; structure given in first source		2.0110
phosphorus radioisotopes
Phosphorus Radioisotopes: Unstable isotopes of phosphorus that decay or disintegrate emitting radiation. P atoms with atomic weights 28-34 except 31 are radioactive phosphorus isotopes.		1.9610
ConditionIndicatedRelationship StrengthStudiesTrials
Bovine Diseases
[description not available]		02.6530
Ectoparasitic Infestations
Infestations by PARASITES which live on, or burrow into, the surface of their host's EPIDERMIS. Most ectoparasites are ARTHROPODS.		02.3620
Parasite Infections
[description not available]		01.9510
Poultry Diseases
Diseases of birds which are raised as a source of meat or eggs for human consumption and are usually found in barnyards, hatcheries, etc. The concept is differentiated from BIRD DISEASES which is for diseases of birds not considered poultry and usually found in zoos, parks, and the wild.		01.9510
Parasitic Diseases, Animal
Animal diseases caused by PARASITES.		01.9510