Compounds > benzoylamidoacetonitrile
Page last updated: 2024-12-07

benzoylamidoacetonitrile

Description

benzamidoacetonitrile: a powerful competitive inhibitor of papain [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID101372
CHEMBL ID1950251
SCHEMBL ID2863808
MeSH IDM0043552

Synonyms (24)

Synonym
n-(cyanomethyl)benzamide
5692-27-3
hippuronitrile
nsc408922
benzamidoacetonitrile
nsc-408922
STK064512
AKOS000268428
benzoylamidoacetonitrile
6fbv0ymd6u ,
unii-6fbv0ymd6u
benzamide, n-(cyanomethyl)-
nsc 408922
CHEMBL1950251
SCHEMBL2863808
benzoylaminoacetonitrile
n-(cyanomethyl)benzamide #
n-(cyanomethyl)benzamid
DTXSID90205466
mfcd01212017
benzamide, n-(cyanomethyl)- (6ci,7ci,8ci,9ci)
(benzoylamino)acetonitrile
2-benzamidoacetonitrile
PD138384
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (15)

Assay IDTitleYearJournalArticle
AID647096Inhibition of papaya papain using methyl hippurate as substrate by titrimetric method2011Bioorganic & medicinal chemistry, Dec-01, Volume: 19, Issue:23
Design, synthesis and biological evaluation of peptidyl-vinylaminophosphonates as novel cysteine protease inhibitors.
AID1160967Inhibition of Bovine thrombin using Boc-Val-Pro-Arg-AMC as substrate compound preincubated at 25 uM for 15 mins by fluorescence assay2014Journal of medicinal chemistry, Sep-25, Volume: 57, Issue:18
Promiscuity and selectivity in covalent enzyme inhibition: a systematic study of electrophilic fragments.
AID1160966Inhibition of West Nile virus NS2B-NS3 protease at 50 uM2014Journal of medicinal chemistry, Sep-25, Volume: 57, Issue:18
Promiscuity and selectivity in covalent enzyme inhibition: a systematic study of electrophilic fragments.
AID1160970Inhibition of wild-type Escherichia coli MurA compound preincubated for 10 mins before substrate addition at 25 uM measured after 15 mins by LC-MS method2014Journal of medicinal chemistry, Sep-25, Volume: 57, Issue:18
Promiscuity and selectivity in covalent enzyme inhibition: a systematic study of electrophilic fragments.
AID1332119Inhibition of Trypanosoma brucei rhodesain using Cbz-Phe-Arg-AMC as substrate at 20 uM by fluorescence-based assay2017Bioorganic & medicinal chemistry letters, 01-01, Volume: 27, Issue:1
Evaluation of dipeptide nitriles as inhibitors of rhodesain, a major cysteine protease of Trypanosoma brucei.
AID1160974Inhibition of wild-type Escherichia coli MurE compound preincubated for 10 mins before substrate addition at 25 uM measured after 15 mins by LC-MS method2014Journal of medicinal chemistry, Sep-25, Volume: 57, Issue:18
Promiscuity and selectivity in covalent enzyme inhibition: a systematic study of electrophilic fragments.
AID1160981Cytotoxicity against human HeLa cells assessed as reduction in cell viability after 24 hrs by CellTiter-Blue assay2014Journal of medicinal chemistry, Sep-25, Volume: 57, Issue:18
Promiscuity and selectivity in covalent enzyme inhibition: a systematic study of electrophilic fragments.
AID1160972Inhibition of wild-type Escherichia coli MurC compound preincubated for 10 mins before substrate addition at 25 uM measured after 15 mins by LC-MS method2014Journal of medicinal chemistry, Sep-25, Volume: 57, Issue:18
Promiscuity and selectivity in covalent enzyme inhibition: a systematic study of electrophilic fragments.
AID1160971Inhibition of wild-type Escherichia coli MurB compound preincubated for 10 mins before substrate addition at 25 uM measured after 15 mins by LC-MS method2014Journal of medicinal chemistry, Sep-25, Volume: 57, Issue:18
Promiscuity and selectivity in covalent enzyme inhibition: a systematic study of electrophilic fragments.
AID1160968Inhibition of Escherichia coli MetAP at 25 uM after 20 mins by HPLC analysis2014Journal of medicinal chemistry, Sep-25, Volume: 57, Issue:18
Promiscuity and selectivity in covalent enzyme inhibition: a systematic study of electrophilic fragments.
AID1160973Inhibition of wild-type Escherichia coli MurD compound preincubated for 10 mins before substrate addition at 25 uM measured after 15 mins by LC-MS method2014Journal of medicinal chemistry, Sep-25, Volume: 57, Issue:18
Promiscuity and selectivity in covalent enzyme inhibition: a systematic study of electrophilic fragments.
AID1160969Inhibition of human MetAP at 25 uM after 20 mins by HPLC analysis2014Journal of medicinal chemistry, Sep-25, Volume: 57, Issue:18
Promiscuity and selectivity in covalent enzyme inhibition: a systematic study of electrophilic fragments.
AID1160965Inhibition of Dengue virus serotype 2 NS2B-NS3 protease at 50 uM2014Journal of medicinal chemistry, Sep-25, Volume: 57, Issue:18
Promiscuity and selectivity in covalent enzyme inhibition: a systematic study of electrophilic fragments.
AID1160976GSH reactivity of the compound assessed as adducts formation by RP-HPLC analysis2014Journal of medicinal chemistry, Sep-25, Volume: 57, Issue:18
Promiscuity and selectivity in covalent enzyme inhibition: a systematic study of electrophilic fragments.
AID1160975Inhibition of wild-type Escherichia coli MurF compound preincubated for 10 mins before substrate addition at 25 uM measured after 15 mins by LC-MS method2014Journal of medicinal chemistry, Sep-25, Volume: 57, Issue:18
Promiscuity and selectivity in covalent enzyme inhibition: a systematic study of electrophilic fragments.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (6)

TimeframeStudies, This Drug (%)All Drugs %
pre-19902 (33.33)18.7374
1990's1 (16.67)18.2507
2000's0 (0.00)29.6817
2010's3 (50.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.27

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.27 (24.57)
Research Supply Index1.95 (2.92)
Research Growth Index4.21 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.27)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other6 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
glycine
[no description available]		1.9510alpha-amino acid;
amino acid zwitterion;
proteinogenic amino acid;
serine family amino acid		EC 2.1.2.1 (glycine hydroxymethyltransferase) inhibitor;
fundamental metabolite;
hepatoprotective agent;
micronutrient;
neurotransmitter;
NMDA receptor agonist;
nutraceutical
arginine
Arginine: An essential amino acid that is physiologically active in the L-form.. arginine : An alpha-amino acid that is glycine in which the alpha-is substituted by a 3-guanidinopropyl group.		1.9510arginine;
glutamine family amino acid;
L-alpha-amino acid;
proteinogenic amino acid		biomarker;
Escherichia coli metabolite;
micronutrient;
mouse metabolite;
nutraceutical
4-nitroacetanilide
[no description available]		2.110
2-chloroacetanilide
[no description available]		2.110
mercury
Mercury: A silver metallic element that exists as a liquid at room temperature. It has the atomic symbol Hg (from hydrargyrum, liquid silver), atomic number 80, and atomic weight 200.59. Mercury is used in many industrial applications and its salts have been employed therapeutically as purgatives, antisyphilitics, disinfectants, and astringents. It can be absorbed through the skin and mucous membranes which leads to MERCURY POISONING. Because of its toxicity, the clinical use of mercury and mercurials is diminishing.. mercury(0) : Elemental mercury of oxidation state zero.		1.9510elemental mercury;
zinc group element atom		neurotoxin
chlorine
Chlorine: An element with atomic symbol Cl, atomic number 17, and atomic weight 35, and member of the halogen family.		1.9510diatomic chlorine;
gas molecular entity		bleaching agent
2-chloro-4-acetotoluidine
[no description available]		2.110
phenyl acetate
phenyl acetate: The ester formed between phenol and acetic acid. Don't confuse with phenylacetic acid derivatives listed under PHENYLACETATES.. phenyl acetate : An acetate ester obtained by the formal condensation of phenol with acetic acid.		1.9510benzenes;
phenyl acetates
n-(n-(3-carboxyoxirane-2-carbonyl)leucyl)isoamylamine
N-(N-(3-carboxyoxirane-2-carbonyl)leucyl)isoamylamine: inhibits calcium-activated neutral protease; see also record for E-64; RN given refers to (2-S-(2alpha,3beta)(R*)-isomer)		2.0610leucine derivative
n-phenylacrylamide
N-phenylacrylamide: structure in first source		2.110
cysteine
Cysteine: A thiol-containing non-essential amino acid that is oxidized to form CYSTINE.. L-cysteinium : The L-enantiomer of cysteinium.. cysteine : A sulfur-containing amino acid that is propanoic acid with an amino group at position 2 and a sulfanyl group at position 3.		1.9610cysteiniumfundamental metabolite
chlorhexidine
Chlorhexidine: A disinfectant and topical anti-infective agent used also as mouthwash to prevent oral plaque.. chlorhexidine : A bisbiguanide compound with a structure consisting of two (p-chlorophenyl)guanide units linked by a hexamethylene bridge.		2.1510biguanides;
monochlorobenzenes		antibacterial agent;
antiinfective agent
ConditionIndicatedRelationship StrengthStudiesTrials
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