| Substance | Relationship Strength | Studies | Trials | Classes | Roles |
|---|
apomorphine
Apomorphine: A derivative of morphine that is a dopamine D2 agonist. It is a powerful emetic and has been used for that effect in acute poisoning. It has also been used in the diagnosis and treatment of parkinsonism, but its adverse effects limit its use. | 1.99 | 1 | 0 | aporphine alkaloid | alpha-adrenergic drug;
antidyskinesia agent;
antiparkinson drug;
dopamine agonist;
emetic;
serotonergic drug |
cytisine
[no description available] | 7.03 | 1 | 0 | alkaloid;
bridged compound;
lactam;
organic heterotricyclic compound;
secondary amino compound | nicotinic acetylcholine receptor agonist;
phytotoxin;
plant metabolite |
magnoflorine
magnoflorine: opium alkaloid having the aporphine configuration; RN given refers to parent cpd(S)-isomer; structure. (S)-magnoflorine : An aporphine alkaloid that is (S)-corytuberine in which the nitrogen has been quaternised by an additional methyl group. | 1.99 | 1 | 0 | aporphine alkaloid;
quaternary ammonium ion | plant metabolite |
lupinine
lupinine: RN given refers to parent cpd(1R-trans)-isomer; structure | 2 | 1 | 0 | quinolizidine alkaloid | |
lupanine
lupanine: formed by coupling of lupinine with pyridine; lupinine is also available; RN given refers to parent cpd(7S-(7alpha,7abeta,14alpha,14aalpha))-isomer; structure. lupanine : The delta-lactam obtained by formal oxidation at the 2-position of sparteine. The major alkaloid from the seeds of Lupinus exaltatus, L. mexicanus and L. rotundiflorus, it is among the most important of the tetracyclic quinolizidine alkaloids. | 2.46 | 2 | 0 | delta-lactam;
quinolizidine alkaloid;
tertiary amine | |
pumiliotoxin c
pumiliotoxin C: isolated from skin of Dendrobates pumilio (frog); see also records for pumiliotoxin A, pumiliotoxin B & pumiliotoxins | 2 | 1 | 0 | | |
sophocarpine
[no description available] | 2.21 | 1 | 0 | | |
costaclavin
costaclavin: RN given refers to (8beta,10beta)-isomer | 2 | 1 | 0 | | |
sophoramine
sophoramine: structure given in first source | 2.21 | 1 | 0 | naphthyridine derivative | |
ammodendrine
ammodendrine: structure given in first source; RN given refers to (R)-isomer. ammodendrine : A piperidine alkaloid that is piperidine substituted by a 1-acetyl-1,4,5,6-tetrahydropyridin-3-yl group at position 2 (the 2R-stereoisomer). | 7.04 | 1 | 0 | acetamides;
N-acylpiperidine;
piperidine alkaloid | plant metabolite;
teratogenic agent |
thermospine
thermospine: structure given in first source | 2.03 | 1 | 0 | | |
n-methylcytisine
N-methylcytisine: alkaloid from Sophora flavescens with anthelmintic activity; RN given refers to parent cpd(1R)-isomer; structure given in first source | 3.53 | 2 | 0 | | |
beta-escin
[no description available] | 3.18 | 1 | 0 | | |
ergoline
Ergolines: A series of structurally-related alkaloids that contain the ergoline backbone structure.. ergoline : An indole alkaloid whose structural skeleton is found in many naturally occurring and synthetic ergolines which are known to bind to neurotransmitter receptors, such as dopamine, noradrenaline and serotonin receptors and function as unselective agonists or antagonists at these receptors. | 2 | 1 | 0 | diamine;
ergoline alkaloid;
indole alkaloid fundamental parent;
indole alkaloid;
organic heterotetracyclic compound | |
piperidines
Piperidines: A family of hexahydropyridines. | 2.04 | 1 | 0 | | |