Compounds > 3-oxauracil
Page last updated: 2024-12-06

3-oxauracil

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth

Description

3-Oxauracil, also known as uracil-6-one, is a heterocyclic compound related to uracil. It is a derivative of uracil with an additional carbonyl group at the 3-position. 3-Oxauracil has been studied for its potential biological activities, including its effects on DNA synthesis and its role in the formation of certain types of cancer. Its synthesis involves a multi-step process, and its effects are typically investigated in cell culture or animal models. Further research is needed to fully understand the role of 3-oxauracil in biological systems.'

3-oxauracil: structure [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID73278
CHEMBL ID3250627
SCHEMBL ID288527
MeSH IDM0064635

Synonyms (25)

Synonym
3h-[1,3]oxazine-2,6-dione
2h-1,3-oxazine-2,6(3h)-dione
3h-1,3-oxazine-2,6-dione
nsc 163038
brn 0112222
1,3-oxazine-2,6-dione
2,3-dihydro-1,3-6h-oxazine-2,6-dione
nsc163038
3-oxauracil
2h-1,6(3h)-dione
34314-63-1
nsc-163038
AKOS004903244
unii-14lw71vvm6
14lw71vvm6 ,
2-27-00-00295 (beilstein handbook reference)
CHEMBL3250627
WQAIPNTUCFSZRZ-UHFFFAOYSA-N
SCHEMBL288527
DTXSID30187878
oxy-6h-1,3-oxazin-6-one
A912662
FT-0725220
2,3-dihydro-6h-1,3-oxazine-2,6-dione
CS-0359236
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (4)

Assay IDTitleYearJournalArticle
AID1136852Growth inhibition of mouse L1210 cells1979Journal of medicinal chemistry, May, Volume: 22, Issue:5
Synthesis and biological activity of 5-fluoro- and 5-methyl-1,3-oxazine-2,6(3H)-dione.
AID1136850Growth inhibition of Streptococcus faecium1979Journal of medicinal chemistry, May, Volume: 22, Issue:5
Synthesis and biological activity of 5-fluoro- and 5-methyl-1,3-oxazine-2,6(3H)-dione.
AID1136851Growth inhibition of Escherichia coli1979Journal of medicinal chemistry, May, Volume: 22, Issue:5
Synthesis and biological activity of 5-fluoro- and 5-methyl-1,3-oxazine-2,6(3H)-dione.
AID1136864Stability of the compound in synthetic growth medium assessed as compound remaining at 37 degC after 16 hrs1979Journal of medicinal chemistry, May, Volume: 22, Issue:5
Synthesis and biological activity of 5-fluoro- and 5-methyl-1,3-oxazine-2,6(3H)-dione.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (11)

TimeframeStudies, This Drug (%)All Drugs %
pre-199010 (90.91)18.7374
1990's1 (9.09)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other12 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
uracil
2,4-dihydroxypyrimidine: a urinary biomarker for bipolar disorder		3.5690pyrimidine nucleobase;
pyrimidone		allergen;
Daphnia magna metabolite;
Escherichia coli metabolite;
human metabolite;
mouse metabolite;
prodrug;
Saccharomyces cerevisiae metabolite
fluorouracil
Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.. 5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.		1.9910nucleobase analogue;
organofluorine compound		antimetabolite;
antineoplastic agent;
environmental contaminant;
immunosuppressive agent;
radiosensitizing agent;
xenobiotic
methotrexate
[no description available]		1.9610dicarboxylic acid;
monocarboxylic acid amide;
pteridines		abortifacient;
antimetabolite;
antineoplastic agent;
antirheumatic drug;
dermatologic drug;
DNA synthesis inhibitor;
EC 1.5.1.3 (dihydrofolate reductase) inhibitor;
immunosuppressive agent
ConditionIndicatedRelationship StrengthStudiesTrials
Leukemia L 1210
[description not available]		02.8740
Avian Sarcoma
[description not available]		01.9510
Brain Inflammation
[description not available]		01.9610
Herpes Simplex Virus Infection
[description not available]		01.9610
Encephalitis
Inflammation of the BRAIN due to infection, autoimmune processes, toxins, and other conditions. Viral infections (see ENCEPHALITIS, VIRAL) are a relatively frequent cause of this condition.		01.9610
Herpes Simplex
A group of acute infections caused by herpes simplex virus type 1 or type 2 that is characterized by the development of one or more small fluid-filled vesicles with a raised erythematous base on the skin or mucous membrane. It occurs as a primary infection or recurs due to a reactivation of a latent infection. (Dorland, 27th ed.)		01.9610
Leukemia, Lymphocytic
[description not available]		01.9610
Granulocytic Leukemia
[description not available]		01.9610
Acute Myelogenous Leukemia
[description not available]		01.9610
Leukemia, Lymphoid
Leukemia associated with HYPERPLASIA of the lymphoid tissues and increased numbers of circulating malignant LYMPHOCYTES and lymphoblasts.		01.9610
Leukemia, Myeloid
Form of leukemia characterized by an uncontrolled proliferation of the myeloid lineage and their precursors (MYELOID PROGENITOR CELLS) in the bone marrow and other sites.		01.9610
Leukemia, Myeloid, Acute
Clonal expansion of myeloid blasts in bone marrow, blood, and other tissue. Myeloid leukemias develop from changes in cells that normally produce NEUTROPHILS; BASOPHILS; EOSINOPHILS; and MONOCYTES.		01.9610
Experimental Neoplasms
[description not available]		01.9510
EHS Tumor
[description not available]		01.9510